Mean Platelet Volume, a Novel Biomarker in Adolescents with Severe Primary Dysmenorrhea

Kucur, Suna Kabil; Seven, Ali; Yüksel, Kadriye Beril; Şencan, Halime; Gözükara, İlay; Keskın, Nadi

doi:10.1016/j.jpag.2016.01.128

Cited by 5 publications

(1 citation statement)

References 19 publications

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“…Incebiyik et al reported low MPV values in pelvic inflammatory disease, and emphasized its diagnostic value [ 18 ]. Reduced MPV levels have also been implicated in non-small cell lung cancer, multiple myeloma, and severe primary dysmenorrhea [ 19 – 21 ]. However, the mechanism responsible for the low MPV in patients with ovarian cancer remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Single and combined use of red cell distribution width, mean platelet volume, and cancer antigen 125 for differential diagnosis of ovarian cancer and benign ovarian tumors

Qin¹,

Wu²,

Xian³

et al. 2018

J Ovarian Res

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BackgroundCancer is widely believed to result from chronic inflammation, and red cell distribution width (RDW) and mean platelet volume (MPV) are considered as inflammatory markers for cancer. We investigated the values of RDW, MPV, and cancer antigen 125 (CA125), alone or in combination, for distinguishing between ovarian cancer and benign ovarian tumors.MethodsThe study included 326 patients with ovarian cancer, 290 patients with benign ovarian tumors, and 162 control subjects. Hematologic tests were performed at initial diagnosis.ResultsRDW was increased and MPV was decreased in the ovarian cancer group compared with the control and benign ovarian tumor groups. RDW was positively correlated and MPV was negatively correlated with cancer stage. Area under the curve (AUC) analysis for ovarian cancer versus benign ovarian tumors revealed that the specificity and sensitivity were increased for the combination of MPV and CA125 compared with either marker alone, and the specificity was increased for the combination of RDW and CA125, compared with either alone. The AUCs for RDW plus CA125 and MPV plus CA125 were significantly larger than for any of the markers alone.ConclusionsIn conclusion, combinations of the markers RDW, MPV, and CA125 may improve the differential diagnosis of ovarian cancer and benign ovarian tumors.

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Section: Discussionmentioning

confidence: 99%

Single and combined use of red cell distribution width, mean platelet volume, and cancer antigen 125 for differential diagnosis of ovarian cancer and benign ovarian tumors

Qin¹,

Wu²,

Xian³

et al. 2018

J Ovarian Res

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show abstract

Red cell distribution width and mean platelet volume detection in patients with endometrial cancer and endometrial hyperplasia

Rafiei Sorouri,

Kabodmehri,

Milani

et al. 2024

Health Science Reports

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BackgroundEndometrial cancer is the most common malignancy in women in developed countries, and its incidence is increasing annually. Due to the availability and cost‐effectiveness of serum markers of red cell distribution width (RDW), and mean platelet volume (MPV), we decided to investigate these two important markers in patients with endometrial cancer and assess their role in diagnosing the tumor and differentiate it from endometrial hyperplasia and other causes of bleeding.MethodsThis is a case‐control study that examined the data of patients who were referred to Al‐Zahra Hospital during 2022–2023 with complaints of abnormal bleeding and underwent diagnostic curettage. Based on the pathology findings, the patients were divided into 3 groups, including endometrial cancer, endometrial hyperplasia, and control. The clinical characteristics and results of MPV and RDW were compared in these three groups. The IBM SPSS Statistics for Windows, Version 21.0. was used for data analysis.ResultsIn this study, 87 women were examined in three groups endometrial cancer, endometrial hyperplasia, and control with a mean age of 52.70 ± 11.63 years. The results showed that the endometrial cancer group, had higher gravida, underlying disease, history of radiation therapy, anticoagulant therapy, blood transfusion, surgery, and family history of cancer (p < 0.05). Meanwhile, the endometrial cancer group had lower menstrual age and history of using contraceptives than other groups (p < 0.05). In addition, in this study, the results indicated that the levels of MPV and RDW in the endometrial cancer group were significantly higher than in the endometrial hyperplasia and control groups (p < 0.05).ConclusionSince MPV and RDW are cheap and accessible and can be easily obtained from complete blood count panels, they can be used as suitable diagnostic markers for endometrial cancer. However, conducting comprehensive multicenter prospective studies with a larger sample size can be helpful.

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Menstrual problems in adolescence: relationship to serum vitamins A and E, and systemic inflammation

Bahrami

Bahrami‐Taghanaki

Khorasanchi

et al. 2019

Arch Gynecol Obstet

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Mean Platelet Volume, a Novel Biomarker in Adolescents with Severe Primary Dysmenorrhea

Cited by 5 publications

References 19 publications

Single and combined use of red cell distribution width, mean platelet volume, and cancer antigen 125 for differential diagnosis of ovarian cancer and benign ovarian tumors

Single and combined use of red cell distribution width, mean platelet volume, and cancer antigen 125 for differential diagnosis of ovarian cancer and benign ovarian tumors

Red cell distribution width and mean platelet volume detection in patients with endometrial cancer and endometrial hyperplasia

Menstrual problems in adolescence: relationship to serum vitamins A and E, and systemic inflammation

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