Mean platelet volume and central retinal vein occlusion in hypertensive patients

Bawankar, Pritam; Samant, Preetam; Lahane, Tatyarao; Parekh, Ragini; Lahane, Sayalee

doi:10.1016/j.jcjo.2018.04.014

Cited by 11 publications

(30 citation statements)

References 28 publications

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“…5,6,16 In addition, there is also one publication reporting that MPV is significantly higher in hypertensive patients with CRVO than the hypertensive control group. 17 In this study, control subjects were randomly selected from hypertensive patients instead of normal healthy individuals in order to eliminate the effect of hypertension alone on platelet parameters.…”

Section: Discussionmentioning

confidence: 99%

Central retinal vein occlusion associated with platelet activation

Çıtırık

2019

Ophthalmol Eye Dis

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Purpose:The aim of this article is to determine and compare the platelet activation by three main platelet activation parameters: mean platelet volume, platelet distribution width, and plateletcrit in patients with central retinal vein occlusion and control subjects.Methods:This study included 30 patients with nonischemic central retinal vein occlusion and 30 control subjects. The levels of mean platelet volume, platelet distribution width, and plateletcrit were measured in all groups.Results:The mean serum level of mean platelet volume was 10.01 ± 0.89 fl in central retinal vein occlusion group and 8.74 ± 1.45 fl in control group. The mean serum level of platelet distribution width was 14.31 ± 1.49% and 11.65 ± 1.81% in central retinal vein occlusion group and control group, respectively. Mean serum plateletcrit value was 0.27 ± 0.07% in central retinal vein occlusion group and 0.23 ± 0.07% in control group. Mean platelet volume, platelet distribution width, and plateletcrit levels were significantly higher in central retinal vein occlusion patients than controls ( p < 0.05).Conclusion:Subclinical platelet activation reflected by mean platelet volume, platelet distribution width, and plateletcrit may have an impact on the genesis of vessel occlusion in central retinal vein occlusion. The results may be important for the clinical management of patients with central retinal vein occlusion.

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Section: Discussionmentioning

confidence: 99%

Central retinal vein occlusion associated with platelet activation

Çıtırık

2019

Ophthalmol Eye Dis

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“…Hypertension and atherosclerosis are the major risk factors for CRVO and play significant roles in its pathophysiology [4]. They lead to hardening and thickening of the arteriolar wall, and the thickened artery compresses the vein within a common adventitial sheath inducing turbulence, endothelial damage, and thrombosis of the retinal venous tree [5,6]. There are also ocular risk factors such as glaucoma, shorter axial length, focal arteriolar narrowing, and arteriovenous (AV) nicking [7,8] The diagnosis of acute RVO is performed by fundoscopy, the characteristic signs are flame hemorrhages, dot and blot hemorrhages, cotton wool spots, hard exudates, retinal edema, and dilated tortuous veins [7].…”

Section: Introductionmentioning

confidence: 99%

Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study

Nicolai

Franceschi

Turris

et al. 2019

JCM

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Purpose: To investigate papillary microvascular changes in patients affected by macular edema due to Central Retinal Vein Occlusions (CRVO) after anti-Vascular Endothelial Growth Factor (VEGF) therapy. Methods: Prospective analysis of papillary and peripapillary vessel density (VD) changes in 18 eyes of 18 hypertensive patients affected by CRVO before and after the loading-phase of intravitreal Ranibizumab (IVR) injections. Data were quantitatively measured by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) before as well as 1 month and 4 months after injections. The correlation between post-treatment best-corrected visual acuity (BCVA) and changes in the retinal microvasculature evaluated by OCTA was assessed. Results: 18 eyes of 18 consecutive patients with a known history of arterial hypertension and affected by an acute CRVO episode were enrolled. Central macular thickness (CMT) was significantly reduced after IVR injections (p < 0.001), while mean BCVA improved from 0.70 ± 0.26 logarithm of the minimal angle of resolution (logMAR) units at baseline to 0.25 ± 0.18 logMAR units after 4 months (p < 0.001). VD inside disc and peripapillary significantly increased (p < 0.001 and p = 0.01, respectively) after treatment. Conclusions: OCTA showed VD increase in the papillary area in patients affected by CRVO after anti-VEGF therapy. This area could represent a new region of interest to study microvasculature changes concomitant with severe macular edema.

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“…The classification of this disorder depends on the site of occlusion: branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) [ 1 ]. The pathogenesis of RVO is still not fully elucidated but is believed to be multifactorial and depends on both local and systemic factors [ 2 , 3 ]. High intra-ocular pressure, glaucoma and short axial distance are regarded as local factors predisposing to RVO [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…This pressure results in a haemodynamic disturbance in blood flow and, in consequence, to damage to the endothelium. These modifications, according to the assumptions of Virchow’s triad, lead to thrombus formation, and eventually vessel occlusion [ 2 , 3 , 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Both arterial and venous thrombosis are characterised by a hypercoagulable state, as well as inflammation, the presence of prothrombotic microparticles and excessive platelet activation [ 10 ]. The pathogenic mechanism underlying the prothrombotic tendency in retinal vein occlusion is still not fully understood [ 3 , 5 ]. The literature suggests that monitoring selected parameters of blood platelets, such as platelet count, mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (PLCR) could be useful in the diagnosis of RVO [ 4 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Platelet and Thrombophilia-Related Risk Factors of Retinal Vein Occlusion

Marcinkowska

Cisiecki

Różalski

2021

JCM

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Retinal vein occlusion (RVO) is a heterogenous disorder in which the formation of a thrombus results in the retinal venous system narrowing and obstructing venous return from the retinal circulation. The pathogenesis of RVO remains uncertain, but it is believed to be multifactorial and to depend on both local and systemic factors, which can be divided into vascular, platelet, and hypercoagulable factors. The vascular factors include dyslipidaemia, high blood pressure, and diabetes mellitus. Regarding the platelet factors, platelet function, mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (PLCR) play key roles in the diagnosis of retinal vein occlusion and should be monitored. Nevertheless, the role of a hypercoagulable state in retinal vein occlusion remains unclear and requires further studies. Therefore, the following article will present the risk factors of RVO associated with coagulation disorders, as well as the acquired and genetic risk factors of thrombophilia. According to Virchow’s triad, all factors mentioned above lead to thrombus formation, which causes pathophysiological changes inside venous vessels in the fundus of the eye, which in turn results in the vessel occlusion. Therefore, a diagnosis of retinal vein occlusion should be based on both eye examination and general examination, including laboratory tests.

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Mean platelet volume and central retinal vein occlusion in hypertensive patients

Cited by 11 publications

References 28 publications

Central retinal vein occlusion associated with platelet activation

Central retinal vein occlusion associated with platelet activation

Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study

Platelet and Thrombophilia-Related Risk Factors of Retinal Vein Occlusion

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