Mean platelet volume and vitamin D deficiency may not be related in diabetic patients

Beyan, Cenǵiz; Beyan, Eśin

doi:10.1016/j.ando.2014.11.002

Cited by 3 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lower MPV values in GDM patients as compared to healthy women were the most important finding of our study, especially in light of the fact that in most previous studies MPV values in GDM patients values were either higher (17,19,20), or the same as in healthy controls (16). Currently, the MPV test is not regarded as a marker of platelet function because of the test results may be affected by the following factors: time from obtaining the specimen until the analysis, the use of anticoagulated tubes, and the lack of a standardized method of measurement (21,22). Taking into consideration of the results of the above-mentioned studies, it seems safe to conclude that -regardless of the MPV values in GDM patients in these studies -the MPV values in GDM samples are not associated directly with the disease, as mentioned before, but are most likely attributable to pre-analytical factors and analytical limits.…”

Section: Discussionmentioning

confidence: 60%

A Study of Inflammatory Markers in Gestational Diabetes Mellitus

Mertoğlu¹,

Günay²,

Güngör³

et al. 2019

Gynecol Obstet Reprod Med

View full text Add to dashboard Cite

Objective: Gestational diabetes mellitus is a common disorder of carbohydrate metabolism, with onset or first recognition during pregnancy, resulting in hyperglycemia of variable severity. Insulin resistance and chronic subclinical inflammation are the underlying mechanisms of the disease. Soluble interleukin-2 receptor, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio are the markers of inflammatory disease processes such as type 1 and 2 diabetes mellitus, hepatitis, and neoplasms.Study Design: In our study, we measured complete blood count, serum soluble interleukin-2 receptor, serum glucose in blood samples from 52 women with gestational diabetes mellitus and 50 pregnant women with normal glucose tolerance. Pregnant women which were tested for oral glucose tolerance test (75 gr load) between 24 and 28 weeks of pregnancy were selected for the study. Gestational diabetes mellitus was defined according to the criteria provided by the National Institute for Health and Care Excellence. Results: In terms of age, gestational diabetes mellitus patients (mean±SD; 31±6 years) were older than controls (mean±SD; 25±5.3 years). Mean platelet volume values were lower in gestational diabetes mellitus patients (mean±SD; 10.3±1.4 fL) as compared to normal glucose tolerance group (mean±SD; 10.8±1fL). No statistically significant differences in serum glucose concentration, white blood cell count, neutrophil count, lymphocyte count, hemoglobin concentration, platelet count, neutrophil-to-lymphocyte ratio value, platelet-to-lymphocyte ratio value, and serum soluble interleukin-2 receptor concentration were found. Conclusion: This study did not reveal an increase in the inflammatory markers, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and serum soluble interleukin-2 receptor, in gestational diabetes mellitus. The mean platelet volume values were observed to be lower in gestational diabetes mellitus patients.

show abstract

Section: Discussionmentioning

confidence: 60%

A Study of Inflammatory Markers in Gestational Diabetes Mellitus

Mertoğlu¹,

Günay²,

Güngör³

et al. 2019

Gynecol Obstet Reprod Med

View full text Add to dashboard Cite

show abstract

“…As stated in the literature, MPV values are affected by conditions such as storage conditions, time, temperature difference, characteristics of the device, and long waiting time in ethylene diamine tetra acetic acid (EDTA) tubes. Even when ethylene diamine tetra acetic acid (EDTA) is used, it is known that MPV values increase with the direct effect of EDTA on platelets [23,24,25,26].…”

Section: Discussionmentioning

confidence: 99%

B12 vitamin eksikliği olan kişilerin tam kan, ortalama trombosit hacmi (MPV) ve nötrofil-lenfosit oranlarının (NLR) değerlendirilmesi

DURMAZ

2022

Family Practice and Palliative Care

View full text Add to dashboard Cite

Introduction: It was aimed to investigate the effects of vitamin B12 deficiency on blood tests, mean platelet volume (MPV), and neutrophil-lymphocyte ratio (NLR), which is one of the inflammation markers.Methods: Our study is a case-control study of 375 patients. 170 patients with low B12 (<130 pg/dL) were accepted as the experimental group, and 205 individuals with normal B12 levels were accepted as the control group. Between these two groups, white blood cells (WBC), platelet count (Plt), hemoglobin (Hgb), mean erythrocyte volume (Mean Corpuscular Volume-MCV), mean platelet volume (Mean Platelet Volume-MPV), neutrophil, lymphocyte counts, and neutrophil -lymphocyte ratios (NLR) were examined.Results: The mean age was 48.45 ±17.497 years in the B12 deficient group and 51.93 ±16.175 years in the control group. The mean of vitamin B12 in the deficient group was 101.41 ± 20.50 pg/mL (min-max 37-130), while it was 257.24 ± 88.13 pg/mL (131–498) in the control group. It was observed that there was no statistically significant difference between WBC, Hgb, Plt, neutrophil, lymphocyte, MVC, MPV and NLR values.Conclusion: In our study, we could not find a significant relationship between B12 deficiency and blood tests. In previous studies, there has been information that MPV values are affected by B12 deficiency. In our study, we found that there was no significant relationship between B12 deficiency and MPV or NLR (p > 0.05). There is a need for new studies on how B12 deficiency will change as the degree and duration of B12 deficiency increases, especially its effect on atherogenic events.

show abstract