Mean platelet volume as a possible marker for monitoring the disease activity in ulcerative colitis

Bai, Mingjian; Xing, Lingsheng; Feng, Jing; Huang, Lan; Li, J; Li, Guowei

doi:10.1111/ijlh.12495

Cited by 4 publications

(5 citation statements)

References 7 publications

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“…Moreover, MPV correlates negatively with duration of intestinal inflammation, endoscopic index, and clinical activity score in people with IBD [17,25,29,39]. Furthermore, MPV was able to distinguish healthy people from people with Crohn's disease and those with inactive ulcerative colitis [4,23,39]. As seen above, thrombopoiesis abnormalities, increased platelet consumption, and release of immature, smaller platelets from the bone marrow to the peripheral blood can occur [36].…”

Section: Discussionmentioning

confidence: 90%

Platelet abnormalities and platelet-to-lymphocyte ratios in canine immunosuppressant-responsive and non-responsive enteropathy: A retrospective study in 41 dogs

et al. 2021

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Few studies have examined platelet alterations in dogs with chronic enteropathy. Our aim was to investigate platelet count (PLT), mean platelet volume (MPV), and platelet-tolymphocyte ratio (PLR) in dogs diagnosed with immunosuppressant-responsive enteropathy (IRE). In this retrospective study of 41 dogs, data regarding signalment, canine chronic enteropathy clinical activity index (CCECAI), endoscopic and histopathological scores, PLT, MPV, PLR, total serum protein concentrations, albumin, and iron were collected. Clinical response and relapse were assessed with the evaluation of CCECAI over time. One month after starting therapy, dogs with >25% CCECAI reduction were considered responders. During a three-month CCECAI evaluation as part of a twelve-month follow-up, a CCECAI >3 together with a ≥2 unit increase in responder dogs was considered a relapse. PLT and PLR displayed significant negative correlation with MPV. MPV was positively correlated with total protein and albumin levels and negatively correlated with CCECAI. Three dogs were classified as non-responders, and 14 relapsed within 12 months. No differences were observed in PLT, MPV, or PLR between responding/non-responding and relapsing/non-relapsing groups. PLT, MPV, and PLR correlated with total protein, albumin, and CCECAI, confirming PLT as a potential marker, and suggesting MPV as a new marker of clinical efficacy against canine IRE.

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Section: Discussionmentioning

confidence: 90%

Platelet abnormalities and platelet-to-lymphocyte ratios in canine immunosuppressant-responsive and non-responsive enteropathy: A retrospective study in 41 dogs

et al. 2021

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“…Duration of hospitalization was shorter in mild cases compared to the severe cases in SARS CoV-2 pneumonia (9). The median length of hospital stay was reported as 14 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19) days in Chinese population and 5 (3)(4)(5)(6)(7)(8)(9) days in non-Chinese population in a recent study (10). Length of hospital stay was comparable to the literature and longer in advanced involvement subjects compared to the mild involvement subjects in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies in the literature are being studied novel inflammatory markers derived from routine hemogram tests. MPV is one of these markers and found to be associated with various inflammatory conditions, including obesity, lumbar disc hernia, type 2 diabetes mellitus, irritable bowel disease, ulcerative colitis, nasal polyposis, rheumatoid arthritis, thyroiditis and coronary heart disease (13)(14)(15)(16)(17)(18)(19)(20)(21). It is also associated with infectious diseases, such as; sepsis and prostatitis (22-23).…”

Section: Discussionmentioning

confidence: 99%

Hemogram Parametreleri SARS CoV-2 Enfeksiyonunda Geniş Pulmoner Tutulumu Öngörebilir mi?

Coşgun

Kalfaoğlu

Dağıstan

et al. 2022

Sağlık Bilimlerinde Değer

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Amaç: Pandeminin başlangıcından bu yana, yeni koronavirüs enfeksiyonu SARS CoV-2, önemli bir ekonomik maliyetin yanı sıra büyük morbidite ve mortaliteye neden oldu. Hafif pulmoner tutulumu olan SARS CoV-2 hastalarının klinik ve laboratuvar bulgularını ileri akciğer tutulumu olan deneklerle karşılaştırmayı amaçladık. Gereç ve Yöntemler: Bu çalışmada, Bolu Abant İzzet Baysal Universitesi Hastanesi’nde SARS CoV-2 enfeksiyonu nedeniyle yatırılan hastalarda hemogram indeksleri ile akciğer tutulumu arasındaki ilişki araştırıldı. Bu retrospektif çalışmada SARS CoV-2'li olguların toraks BT görüntüleri incelendi. Akciğerlerde hastalığa bağlı radyolojik patern, akciğer tutulum yüzdesi, hemogram parametreleri, eritrosit sedimantasyon hızı (ESR), C-reaktif protein (CRP), aspartat ve alanin transaminazlar (AST ve ALT), laktat dehidrojenaz (LDH), ileri ve hafif akciğer tutulumu olan hastalarda D-dimer, ferritin, total bilirubin, albümin, kreatinin kinaz, serum kreatinin değerleri karşılaştırıldı. Bulgular: İleri akciğer tutulumu (%50'den fazla), ESR (r=0,32, p

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“…It is applied equally to either samples anticoagulated with EDTA or citrate. Although the diagnostic role of MPV has been appreciated for different pathological conditions [18,19], the effect of preanalytical variations on different platelet indices had also been mentioned [20].…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of pneumatic tube transport system on platelet indices: EDTA or citrate anticoagulant?

Kecskemétiné¹,

Csiki

Mile

et al. 2017

Int J Lab Hematology

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Mean platelet volume as a possible marker for monitoring the disease activity in ulcerative colitis

Cited by 4 publications

References 7 publications

Platelet abnormalities and platelet-to-lymphocyte ratios in canine immunosuppressant-responsive and non-responsive enteropathy: A retrospective study in 41 dogs

Platelet abnormalities and platelet-to-lymphocyte ratios in canine immunosuppressant-responsive and non-responsive enteropathy: A retrospective study in 41 dogs

Hemogram Parametreleri SARS CoV-2 Enfeksiyonunda Geniş Pulmoner Tutulumu Öngörebilir mi?

The clinical significance of pneumatic tube transport system on platelet indices: EDTA or citrate anticoagulant?

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