Mean Platelet Volume as a Marker of Sepsis in Patients Admitted to Intensive Therapy

Sanchez-Calzada, A; Jl, Navarro; Delgado, L.; Torres, Orlando Jorge Martins; Torres, Antoni; Gastelum, R; Romano, P; Monares, E; Galindo, Cheryl; Camarena, G; Aguirre, Janet S; Franco, Juvenal

doi:10.1186/2197-425x-3-s1-a871

Cited by 4 publications

(3 citation statements)

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“…Several studies have demonstrated the predictive utility of MPV in sepsis 9,[11][12][13][14][15][16][17][18][19][20][21][22][23][24] however;, there is little reported bibliography that compares platelet kinetics in critically ill patients with and without sepsis, a critical situation to be demonstrated since several non-infectious diseases can also potentially increase platelet size.…”

Section: Discussionmentioning

confidence: 99%

The behavior of Mean Platelet Volume in Sepsis in critical patients with and without sepsis

Páez¹,

Páez

2021

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The mean platelet volume is an anatomical biomarker that has shown its usefulness in various cardiovascular and metabolic pathologies; in sepsis, it has been positioning itself as an indicator of mortality, easily accessible and immediately applicable when reported in the routine blood count. This study demonstrates the mean platelet volume's biological behavior in critical patients with sepsis compared with non-septic patients. An observational, longitudinal, prospective, monocentric cohort study was conducted in 250 patients treated at the intensive care unit of the Pablo Arturo Suárez Hospital, Quito- Ecuador, from January 2019 January 2020. A group of patients with sepsis (n = 125) and without infectious pathologies (n = 125) were studied. The inclusion criteria were patients over 18 years of age of both genders, diagnosed with sepsis or septic shock using SEPSIS 3 criteria, and patients without septic pathology. The mean platelet volume (MPV) of days 1, 2, and 3 were studied. Septic patients had a mean APACHE (18.74 SD 9.52) higher than the non-septic ones (11.93 SD 7.01) (p = < 0.000). The MPV was consistently higher in patients with sepsis than non-septic patients, but it reached statistical significance on day 3 (9.13 SD 1.55 vs. 8.66 SD 1.34, p=0.042). The MPV on day 3 presented a significant area under the curve (AUC =0.580) (CI. 0.500-0.661), where the cut-off point according to Youden's index was positive for sepsis if MPV≥ 9.85 femtoliter (fL) with OR=3.30 and p-value= 0.005. Likewise, lactate on admission showed an AUC of 0.625 (CI. 0.555-0.694), with a cut-off point ≥of 1.15 mmol / L, OR=2.51, and p=0.007. Age and hypertension did not show a multivariate relationship with the presence of sepsis. It was shown that MPV is higher in patients with sepsis compared to non-septic ones. This observation reaches significance on day 3. Additionally, elevated lactate at admission was also associated with a septic state. On the other hand, platelet count did not show the expected behavior.

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Section: Discussionmentioning

confidence: 99%

The behavior of Mean Platelet Volume in Sepsis in critical patients with and without sepsis

Páez¹,

Páez

2021

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“…Sánchez-Calzada et al, en un estudio prospectivo con 202 pacientes, determinaron que el VMP inferior a 7,7 fl es una herramienta útil para descartar etiología infecciosa del síndrome de respuesta inflamatoria sistémica (9). En 2015, Ates et al, realizaron un estudio de casos y controles intentando determinar si el VMP y la razón VMP/contaje plaquetario podían determinar si el síndrome de respuesta inflamatoria sistémica se debía a procesos sépticos, sin éxito ya que los valores de sensibilidad y especificidad tanto del VMP y la razón VMP/contaje plaquetario fueron bajos y sin significancia estadística (10).…”

Section: Vmp Y Sepsisunclassified

¿El volumen medio plaquetario es un es un predictor de mortalidad en pacientes sépticos? Revisión de la literatura

Vélez¹

2018

Rev Med Hered

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La sepsis es una de las causas más frecuentes que motivan el ingreso de pacientes al hospital y a las unidades de cuidados intensivos, tiene alto impacto en la morbilidad y mortalidad. Pese a los avances tecnológicos que han permitido mejorar el soporte de fallos orgánicos, no se ha logrado disminuir de forma importante sus complicaciones. Por ello es importante tener herramientas que sean predictoras de severidad en esta patología; los biomarcadores (procalcitonina, pro adrenomodulina, interleuquina 6), se han convertido en buenos índices de pronostico y evolución, sin embargo, su disponibilidad ya sea por el costo o existencia de reactivos en los distintos laboratorios no es constante; es por ello que buscamos con ésta revisión determinar si el uso del volumen medio plaquetario, un biomarcador reportado en el hemograma común y que se viene usando con relativo éxito en patologías cardiovascular, metabólica e inflamatoria/infecciosa, como un indicador de pronóstico de severidad y mortalidad.

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“…MPV rising is useful in cardiovascular and cerebrovascular thromboembolic events [15], heart failure [16], infective endocarditis [17], venous thromboembolism [18]. MPV is helpful in sepsis diagnosis [19], course monitoring, and prognosis [11,20].…”

Section: Introductionmentioning

confidence: 99%

Comparative study between complete blood picture indices and presepsin as early prognostic markers in septic shock patients

Said

Fayed

El-Reweny

2020

Egyptian Journal of Anaesthesia

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Mean Platelet Volume as a Marker of Sepsis in Patients Admitted to Intensive Therapy

Abstract: Sanchez-Calzada et al.: Mean platelet volume as a marker of sepsis in patients admitted to intensive therapy. Intensive Care Medicine Experimental 2015 3(Suppl 1):A871.

Cited by 4 publications

References 0 publications

The behavior of Mean Platelet Volume in Sepsis in critical patients with and without sepsis

The behavior of Mean Platelet Volume in Sepsis in critical patients with and without sepsis

¿El volumen medio plaquetario es un es un predictor de mortalidad en pacientes sépticos? Revisión de la literatura

Comparative study between complete blood picture indices and presepsin as early prognostic markers in septic shock patients

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