Mean platelet volume as an inflammation marker in active pulmonary tuberculosis

Abstract

Background: The mean platelet volume (MPV) reflects the size of platelets. It has been shown to be inversely correlated with level of the inflammation in some chronic inflammatory diseases. This prospective study aims to show the usability of MPV as an inflammation marker in patients with active pulmonary tuberculosis (PTB) by comparison with healthy controls. In addition, its relationships with other inflammatory markers such as C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) as well as with the radiological extent of disease were examined.
 Methods: This study included 82 patients with active PTB and 95 healthy subjects (control group). Whole blood counts, CRP level, and ESR were compared between the two groups. In the PTB group, the relationships between the radiological extent of disease and the MPV and other inflammation markers were investigated.
 Results: The MPV was 7.74 ± 1.33/μL in the PTB group and 8.20 ± 1.13/μL in the control group (p = 0.005). The blood platelet count, CRP level, and ESR were significantly higher in the active PTB group than in the control group (p < 0.0001). In the PTB group, CRP levels (r = 0.26, p = 0.003) and ESR (r = 0.39, p = 0.003), but not MPV (p = 0.80), were significantly correlated with the radiologic extent of the disease.
 Conclusions: The MPV was lower in patients with PTB than in healthy controls, however, the difference was limited. The MPV does not reflect the severity of the disease. The use of MPV as an inflammation marker and a negative acute-phase reactant in PTB does not seem to be reliable.

The platelet indices in diagnosis of ventriculoperitoneal shunt infection in children.

“…Guclu et al showed that in patients with severe sepsis, PDW and MPV levels were higher than non-severe sepsis (8). On the other hand, Gunluoglu et al found lower MPV levels in active pulmonary tuberculosis cases but this did not reflect the severity of disease (9).…”

The Mean Platelet Volume Is Decreased in Patients Diagnosed with Venous Thromboembolism in the Emergency Department

“…We also found that a decreased MPV value may be associated with the highest risk of diagnosing VTE in patients with active cancer, thus sup-porting the data recently published by Riedl et al 6 Interestingly, a similar inverse association has also been observed in patients with brain injury after mild head trauma, wherein the frequency of decreased MPV values was 10-and 17-fold higher in patients with negative and positive computed tomography (CT) scans, respectively. 11 Further clinical investigations also showed that reduced platelet size can be observed in patients with chronic obstructive pulmonary disease, 12 pulmonary tuberculosis, 13 and necrotizing pancreatitis. 14 Interestingly, Mutlu et al retrospectively studied 43 patients with cancer who developed VTE and observed that MPV values at the time of development of venous thrombosis were significantly lower compared with the values recorded at the time of cancer diagnosis.…”

Mean Platelet Volume (MPV): New diagnostic indices for co-morbidity of Tuberculosis and Diabetes Mellitus

“…These results were in accordance with our ndings, in that there were no signi cant differences between TB patients and healthy controls. Gunluoglu et al suggested that the value of MPV was slightly decreased in TB patients, and the MPV never re ected the severity of tuberculosis [24].…”

“…However, the role of MPV in TB is disputed. A study conducted by Gunluoglu et al suggested that MPV, as an in ammation marker, decreased in active pulmonary tuberculosis related to the formation of microthrombi in TB cavities [24].…”