The platelet indices in diagnosis of ventriculoperitoneal shunt infection in children.

Çelik, Ümit; Çelik, Tamer; Tolunay, Orkun; Dönmezer, Çiğdem; Gezercan, Yurdal; Mert, Kurthan; Ökten, Ali İhsan

doi:10.5137/1019-5149.jtn.16659-15.1

Cited by 7 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the literature, we found only one study that examined the platelet parameters in VP shunt infection. Çelik and colleagues, as in our study similar, have found that despite the increased platelet count, MPV was found to be lower than the control group (31). In a study evaluating adult patients with bacterial meningitis and tuberculosis meningitis, platelet count was lower and MPV was higher in patients with bacterial meningitis compared to patients with tuberculous meningitis and healthy control group (32).…”

Section: Discussionsupporting

confidence: 70%

Ventriculoperitoneal Shunt Infections in Children: Demographical, Clinical Findings and Evaluation of Thrombocyte Parameters

Gündeşli̇oğlu¹,

Haytaoğlu²,

Özsoy³

et al. 2018

J Pediatr Inf

View full text Add to dashboard Cite

Objective: We investigated demographic, clinical and laboratory characteristics of children with ventriculoperitoneal (VP) shunt infection in this study. The aim of this study was to make a comparison between the values obtained before and after treatment, and those obtained before treatment and of the control groups in terms of platelet count, mean platelet volume (MPV) and platelet distribution width (PDW) values in the diagnosis of VP shunt infection. Material and Methods: In this study, medical records of patients diagnosed with VP shunt infection between the years 2015-2018 were retrospectively reviewed. Healthy children of similar age groups were selected as the control group. The platelet count, MPV and PDW values of the patients were compared before and after treatment, and before treatment and with the control group. Results:13 (39.4%) female and 20 (60.6%) male patients who were diagnosed with VP shunt infection were included in this study. The median age of the patients was 8 months (min-max: 1-106 month). The most common complaints were nausea and vomiting (66.7%) followed by loss of appetite (57.6%) and fever (51.5%). Growth in the cerebrospinal fluid (CSF) culture of 23 (69.7%) patients was detected and the most common cause was Staphylococcus epidermidis (57.6%). At admission, patients with VP shunt infection had mean follow-up platelet counts of 521.969 ± 143.697 µL (min-max: 256.000-854.000 µL) and 25 patients (75.7%) had thrombocytosis. There was statistically significant Özet Giriş: Bu çalışmada ventriküloperitoneal (VP) şant enfeksiyonu gelişen çocuk hastaların demografik, klinik, laboratuvar özellikleri incelenmiştir. VP şant enfeksiyonu tanısında trombosit sayısı, ortalama trombosit hacmi (OTH), trombosit dağılım aralığı (TDA) değerlerinin tedavi öncesi, tedavi sonrası ve tedavi öncesi ile kontrol grubunun karşılaştırılması amaçlanmıştır. Gereç ve Yöntemler: Bu çalışmada 2015-2018 yılları arasında VP şant enfeksiyonu tanısı alan hastaların dosyaları geriye dönük olarak incelendi. Benzer yaş grubundan sağlıklı çocuklar kontrol grubu olarak seçildi. Hastaların tedavi öncesi, sonrası ve tedavi öncesi ile kontrol grubu trombosit sayısı, OTH ve TDA değerleri karşılaştırıldı. Bulgular: Bu çalışmaya VP şant enfeksiyonu tanısı alan 13 (%39.4)'ü kız, 20 (%60.6)'si erkek 33 hasta dahil edildi. Hastaların median yaşı 8 ay (minmaks: 1-106 ay) idi. En sık başvuru yakınması bulantı-kusma (%66.7) olup bunu iştahsızlık (%57.6) ve ateş (51.5) izlemekte idi. Hastaların 23 (%69.7)'ünde beyin omurilik sıvısı (BOS) kültüründe üreme tespit edildi ve en sık etken Staphylococcus epidermidis (%57.6) idi. Ventriküloperitoneal şant enfeksiyonu olan hastaların yatışta bakılan ortalama trombosit değerleri 521.969 ± 143.697 µL (min-maks: 256.000-854.000 µL) olup 25 (%75.7)'inde trombositoz mevcut idi. Hastaların tedavi öncesi ve sonrası trombosit sayıları arasında anlamlı fark bulundu (p= 0.001). Tedavi öncesi ve sonrası OTH değerleri karşılaştırıldığında tedavi öncesi ortalama J Pediatr Inf 2018; 12(2): e63-e69 Ventricu...

show abstract

Section: Discussionsupporting

confidence: 70%

Ventriculoperitoneal Shunt Infections in Children: Demographical, Clinical Findings and Evaluation of Thrombocyte Parameters

Gündeşli̇oğlu¹,

Haytaoğlu²,

Özsoy³

et al. 2018

J Pediatr Inf

View full text Add to dashboard Cite

show abstract

“…Orthopedists often pay attention to white blood cell (WBC) count and neutrophil count in CBC to diagnose or monitor infections; however, their sensitivity and specificity are very low in fracture patients 2,3. Besides WBC count and neutrophil count, recent studies gradually focus on the role of platelet indices including platelet count (PLT), mean platelet volume (MPV), and platelet distribution width (PDW) in diagnosing infections such as acute appendicitis, ventriculo-peritoneal shunt infection, and urinary tract infection 4–7. To our knowledge, there are no studies conducted examining the diagnosis of DSSI after ORIF for traumatic limb fractures using platelet indices.…”

Section: Introductionmentioning

confidence: 99%

The association between platelet indices and deep surgical site infection after open induction internal fixation for traumatic limb fractures

Zhang¹,

Ji²,

Wang³

et al. 2018

IDR

View full text Add to dashboard Cite

ObjectivesDeep surgical site infection (DSSI) is one of the most serious complications after open induction internal fixation (ORIF) for traumatic limb fractures. In this study, we aimed to investigate the diagnostic role of platelet indices (platelet count [PLT], mean platelet volume [MPV], and platelet distribution width [PDW]) in DSSI.Patients and methodsData obtained between January 2011 and December 2017 in The Affiliated Drum Tower Hospital of Nanjing University Medical School from cases (n=29) with DSSI and fracture control subjects (n=29) matched for age, gender, and fracture type were analyzed. The white blood cell (WBC) count, neutrophil count, neutrophil percentage, and platelet indices from blood samples were compared between case and control groups. In addition, the cutoff value, sensitivity, and specificity were calculated by receiver-operating characteristic (ROC) curves.ResultsNo significant differences were detected in demographic features, the WBC count, neutrophil count, neutrophil percentage, and MPV values between two groups (P>0.05). The PLT values were significantly higher in the case group than in the control group (303.00±139.27 vs 196.10±59.61 [109/μL], P=0.001). The PDW values of the case and control groups were 11.77±2.71 and 13.19±2.39%, respectively, and were significantly lower in the case group (P=0.001). ROC curve analysis suggested a cutoff point for PLT as 215.50 (109/μL, larger values indicate pathology) for the diagnosis of DSSI with the sensitivity and specificity of 79.3 and 72.4%, respectively. For PDW, the cutoff point was 10.35% (smaller values indicate patients) for the diagnosis of DSSI with the sensitivity and specificity of 37.9 and 96.6%, respectively.ConclusionOur results suggest that PDW combined with PLT can be used as an important additional test for the diagnosis of DSSI after ORIF for traumatic limb fractures, thus reducing the cost and loss of time.

show abstract

“…14 There have been studies of children in respect of the diagnostic and follow-up value of PDW in many diseases such as immunodeficiency disease, ventriculoperitoneal shunt infection, congenital heart disease, pulmonary arterial hypertension, acute ischemic stroke, and neonatal sepsis. [14][15][16][17][18] Some studies in the literature have shown conflicting results about the supportive value of PDW in the diagnosis of AA . While some of these studies have demonstrated a correlation between PDW and AA, others have reported no change in the value of PDW.…”

Section: Discussionmentioning

confidence: 99%

Is There a Supporting Value of Platelet Distribution Width and Plateletcrit in the Diagnosis of Acute Appendicitis in Children?

Bilici

Öztaş

Dursun

2019

J Pediatr Infect Dis

View full text Add to dashboard Cite

This study was designed to investigate the diagnostic value of platelet distribution width (PDW) and plateletcrit (PCT) for acute appendicitis in childhood. A retrospective review was conducted of the records of 373 patients younger than 18 years who underwent appendectomy. Demographic data, white blood cell count, neutrophil count, and PDW and PCT values were recorded for all patients. A control group was formed of age- and gender-matched healthy children. The study results showed that the PDW level is not valuable as a marker for the diagnosis of acute appendicitis in children. PCT levels were determined to be statistically significantly increased in pediatric acute appendicitis with low specificity.

show abstract

The platelet indices in diagnosis of ventriculoperitoneal shunt infection in children.

Abstract: Our results suggest that MPV and PDW can be used for the diagnosis of VPSI in children with an accuracy of at least 75%. Moreover, MPV"s specificity is higher than the other platelet parameters and leucocyte count.

Cited by 7 publications

References 19 publications

Ventriculoperitoneal Shunt Infections in Children: Demographical, Clinical Findings and Evaluation of Thrombocyte Parameters

Ventriculoperitoneal Shunt Infections in Children: Demographical, Clinical Findings and Evaluation of Thrombocyte Parameters

The association between platelet indices and deep surgical site infection after open induction internal fixation for traumatic limb fractures

Is There a Supporting Value of Platelet Distribution Width and Plateletcrit in the Diagnosis of Acute Appendicitis in Children?

Contact Info

Product

Resources

About