Mean platelet volume change (∆MPV) and red blood cell distribution width (RDW) as promising markers of community-acquired pneumonia (CAP) outcome

Farghly, Sahar; Abd-Elkader, Randa; Zohne, Randa A. El; El-Kareem, Doaa M. Abd

doi:10.1186/s43168-020-00024-z

Cited by 6 publications

(14 citation statements)

References 32 publications

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“…24 In a study evaluating 153 hospitalized patients with communityacquired pneumonia, increased RDW and MPV values were associated with high mortality. 25 Similarly, in our study, both RDW and MPV values were significantly higher in patients with mortality and the MPV value was significantly higher in patients with acute hypercapnic respiratory failure. Although the RDW value was higher in patients with acute hypoxemic respiratory failure, the difference was statistically insignificant.…”

Section: Discussionsupporting

confidence: 83%

An evaluation of noninvasive mechanical ventilation application in intensive care

Karatepe,

Afşar Karatepe,

Hoşgün

2024

JOPIC

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Aims: Noninvasive mechanical ventilation (NIMV) is a positive pressure treatment applied with a mask without the need for endotracheal intubation in patients with acute and chronic respiratory failure. C-reactive protein (CRP), procalcitonin (PCT), albumin, red blood cell distribution width (RDW), and mean platelet volume (MPV) are frequently used markers in clinical practice. Arterial blood gas (ABG) analysis is a standard method in clinical practice in intensive care, which is known to have a higher risk of complications than venous blood gas (VBG) analysis. Studies have shown a strong correlation between ABG and VBG with regard to pH, partial arterial carbon dioxide pressure (PCO2), and serum bicarbonate (HCO3). In this study, we aimed to evaluate the relationship between CRP, PCT, albumin, MPV, and RDW and in-hospital mortality and acute respiratory failure in patients undergoing NIMV. Our secondary aim was to evaluate the relationship between these parameters and VBG values. Methods: Patients with acute hypoxemic and hypercapnic respiratory failure that underwent NIMV in intensive care unit (ICU) were evaluated retrospectively. Results: The study included 99 patients with a mean age of 69.39±9.79 years. In-hospital mortality occurred in 5 (5.1%) patients. Hypercapnic respiratory failure was detected in 66 (66.7%), hypoxemic respiratory failure in 19 (19.2%), and hypoxemic + hypercapnic respiratory failure in 14 (14.1%) patients. PCT was significantly higher in patients with acute hypoxemic respiratory failure and MPV was significantly higher in patients with acute hypercapnic respiratory failure compared to other patients (p<0.05 for both). Both MPV and RDW were significantly higher in patients with in-hospital mortality (p<0.05). The baseline and 24-h PO2/FiO2 ratios were significantly lower in patients with acute hypoxemic + hypercapnic respiratory failure (p<0.05). The 24-h PO2/FiO2 ratio was significantly lower in patients with in-hospital mortality compared to patients without mortality (p<0.05). Conclusion: Both RDW and MPV should be employed in predicting mortality in patients undergoing NIMV due to acute respiratory failure. Further multicenter, prospective studies are needed to evaluate the PaO2/FiO2 ratio particularly in VBG in patients receiving NIMV due to acute respiratory failure.

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Section: Discussionsupporting

confidence: 83%

An evaluation of noninvasive mechanical ventilation application in intensive care

Karatepe,

Afşar Karatepe,

Hoşgün

2024

JOPIC

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“…[7] A study conducted on CAP patients found a significant relationship between RDW and MPV levels and high mortality risk. [19] In our study, however, RDW, MPV, ALB, CRP, and PCT levels were not noted as significant predictors of 90-day mortality. Other studies have mostly evaluated CAP patients, and to the best of our knowledge, there is little documentation on the relationship between these serum markers and long-term independent mortality in HAP patients.…”

Section: Variablescontrasting

confidence: 75%

“…[ 7 ] A study conducted on CAP patients found a significant relationship between RDW and MPV levels and high mortality risk. [ 19 ]…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the factors affecting long-term mortality in geriatric patients followed up in intensive care unit due to hospital-acquired pneumonia

Aydemir¹,

Hoşgün²

2022

Medicine

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Aging is a normal physiological process involving changes in the respiratory system, thereby causing an increased incidence of pulmonary infections such as hospital-acquired pneumonia (HAP). The primary aim of this study was to investigate the role of acute-phase reactants and inflammation-based biomarkers in predicting 90-day mortality in patients aged over 65 years who were hospitalized in the intensive care unit (ICU) due to HAP. Clinical records of patients aged ≥65 years who were diagnosed as having HAP and were followed up in ICU were retrospectively evaluated. One hundred and fifteen ICU patients (67.8% male, mean age 76.81 ± 7.480 years) were studied. Ninety-day mortality occurred in 43 (37.4%) patients. Red cell distribution (RDW, %), mean platelet volume (MPV, f/L), white blood cell count (WBC, 103/μL), C-reactive protein (CRP, mg/L), and procalcitonin (PCT, ng/mL) median values were 18.2 (13.7-35.6), 7.42 (5.66-11.2), 14.3 (3.21-40), 9.58 (0.12-32), 0.41 (0.05-100) in the group with 90-day mortality. In the Receiver Operator Characteristics Curve analysis, a WBC value 18.2 × 10ˆ3/μL predicted 90-day independent mortality with a sensitivity of 90.70% and specificity of 31.94% (P = .029). The results indicated that serum WBC level can be used for predicting long-term mortality and prognosis in HAP patients aged over 65 years. High WBC value was statistically significant in predicting 90-day independent mortality (P < .05).

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“…Nilai RDW yang lebih tinggi memiliki kecenderungan skor indeks keparahan yang lebih tinggi, dan mortalitas pasien yang lebih tinggi juga. 20 Pada penelitian ini didapatkan hasil nilai RDW pada pasien dengan pneumonia berat memiliki rerata 15,48 ± 1,95. Hasil ini sesuai dengan penelitian yang dilakukan oleh Braun et al yang menyatakan bahwa peningkatan RDW >14,5% secara independen terkait dengan beratnya pneumonia yang dinilai dari lama rawat inap >10 hari, masuk ICU dan kematian pada pasien CAP anak.…”

Section: Pembahasanunclassified

Hubungan nilai Red Cell Distribution Width (RDW) dengan tingkat keparahan pneumonia pada pasien anak di RSUD Wangaya Denpasar, Bali-Indonesia

Putri

Suryawan²,

Suarca³

2021

Intisari Sains Medis

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Background: Pneumonia is the highest cause of death in children less than five years old. Based on the 2019 Indonesian Health Profile, there were 52.7% cases of childhood pneumonia in Indonesia. The high number of deaths from pneumonia in children indicates the severity of the symptoms and the clinical deterioration that occurs, so it is essential to find markers that can predict children who are likely to experience clinical deterioration. Red cell distribution width (RDW) is a marker on standard blood tests but is rarely seen clinically. This study aimed to determine the relationship between the RDW value and the severity Latar Belakang: Pneumonia merupakan penyebab kematian tertinggi pada anak usia kurang dari lima tahun. Berdasarkan Profil Kesehatan Indonesia 2019 terdapat 52,7% kasus pneumonia anak di Indoneisa. Tingginya kasus kematian akibat pneumonia pada anak menandakan beratnya gejala yang timbul dan perburukan klinis yang terjadi, sehingga penting untuk menemukan penanda yang dapat memprediksi anak yang cenderung akan mengalami perburukan klinis. Red cell distribution width (RDW) adalah suatu penanda pada pemeriksaan darah standar namun klinisnya jarang diperhatikan. Tujuan penelitian ini adalah untuk mengetahui hubungan nilai RDW dengan tingkat keparahan pneumonia pada pasien anak. of pneumonia in pediatric patients. Methods: The type of research used is an observational analytic study with a cross-sectional approach. Sampling used the consecutive sampling method. The data obtained were analyzed analytically, using the computer program SPSS version 25.0 with chi-square test and independent t-test. Results: The mean RDW was higher in person with severe pneumonia (15.48 ± 1.95) than the group with mild pneumonia (13.73 ± 1.11) (p=0.000). Conclusion:There is a significant relationship between RDW and the severity of pneumonia.Metode: Jenis penelitian yang digunakan adalah studi analitik observasional dengan pendekatan crosssectional. Pengambilan sampel menggunakan metode consecutive sampling. Data yang diperoleh dianalisis secara analitik, menggunakan program computer SPSS versi 25.0 dengan uji chi square dan uji independent t-test. Hasil: Rerata RDW didapatkan lebih tinggi pada kelompok subjek dengan pneumonia berat (15,48 ± 1,95) dibandingkan kelompok dengan pneumonia ringan (13,73 ± 1,11) (p=0,000). Simpulan: Terdapat hubungan bermakna antara RDW dengan tingkat keparahan pneumonia.

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Mean platelet volume change (∆MPV) and red blood cell distribution width (RDW) as promising markers of community-acquired pneumonia (CAP) outcome

Cited by 6 publications

References 32 publications

An evaluation of noninvasive mechanical ventilation application in intensive care

An evaluation of noninvasive mechanical ventilation application in intensive care

Evaluation of the factors affecting long-term mortality in geriatric patients followed up in intensive care unit due to hospital-acquired pneumonia

Hubungan nilai Red Cell Distribution Width (RDW) dengan tingkat keparahan pneumonia pada pasien anak di RSUD Wangaya Denpasar, Bali-Indonesia

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