Mean platelet volume does not seem to relate to thrombosis or posterior uveitis in Behçet's disease

Abstract

Behçet's disease (BD) is a chronic inflammatory disorder in which thrombosis and posterior ocular involvement occur in about 30% of patients, whose ethiology is unknown. It has not been established whether mean platelet volume (MPV), a marker of platelet activation, is involved in the pathogenesis of thrombotic events and posterior uveitis in these patients. We aimed to analyze whether there are differences in MPV in BD patients when compared with controls and its relation with the presence of thrombosis and posterior uveitis. We determined MPV and platelet count, along with Creactive protein (CRP) and cardiovascular risk factors (because of their influence on MPV) in 89 BD patients (of which 24 had thrombosis and 23 had posterior uveitis) and 89 sex-and age-matched healthy controls. BD patients showed statistically higher MPV than controls: 10.98 ± 1.19 fL vs. 10.60 ± 1.21 fL (P = 0.044) and higher CRP: 5.9 ± 8.9 mg/L vs. 1.4 ± 1.7 mg/L (P = 0.001). The percentage of hyperlipemia and diabetes was higher in cases than in controls (P = 0.032, P = 0.013, respectively). No differences in MPV were observed when comparing: patients with and without thrombosis: 11.8 ± 1.27 fL vs. 10.94 ± 1.28 fL (P = 0.654); with and without posterior uveitis: 10.76 ± 1.18 fL vs. 11.03 ± 1.30 fL P = 0.398; with CRP and cardiovascular risk factors (P > 0.05). MPV correlated negatively with platelet count (r = -308, P < 0.01), but not with CRP (r = -0.22, P = 0.772). MPV seems to relate to neither thrombosis nor posterior uveitis in BD patients.

Mean platelet volume as a marker for differentiating disease flare from infection in Behçet's disease

“…In the present study, MPV was significantly lower in patients with BD compared to controls. This is at variance with some previous reports, in which MPV was elevated in patients with BD compared to healthy controls . However, lower MPV has also been reported in patients with BD .…”

Neutrophil‐to‐lymphocyte ratio, mean platelet volume and platelet‐to‐lymphocyte ratio in Behçet’s disease and their correlation with disease activity: A meta‐analysis

“…Three of these were excluded because they were duplicate studies. Thus, 14 articles met the inclusion criteria (Table , Figure ). Eleven studies evaluated MPV, seven studies NLR, three studies adinopectin levels, and three studies PLR levels in the BD and control groups (Table ).…”

“…Behçet’s disease can be classified as active and inactive diseases based on disease activity, and thrombosis occurs often in BD. Studies on MPV, NLR, and PLR in patients with BD in comparison with those in healthy controls, on the indices between active and inactive diseases, and between BD with and without thrombosis have reported controversial results . We performed the present meta‐analysis to overcome the limitations of individual studies and resolve inconsistencies .…”

Mean platelet volume is associated with aortic arterial stiffness in patients with Behçet's disease without significant cardiovascular involvement

“…15 There are only a few studies that MPV levels have been investigated in Behc ßet's disease. 20,36,37 Previous studies was shown that an increase in MPV may indicate the presence of venous thrombosis, but MPV is an inappropriate marker of activity in BD. 20 We concluded that the MPV levels may be used as a cheap and feasible diagnostic marker in patients with BD in previous study.…”