Neutrophil‐to‐lymphocyte ratio, mean platelet volume and platelet‐to‐lymphocyte ratio in Behçet’s disease and their correlation with disease activity: A meta‐analysis

Abstract

Aim We aimed to evaluate the relationship between mean platelet volume (MPV), neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and Behçet’s disease (BD). Methods We searched Medline, Embase, and Cochrane databases, and performed a meta‐analysis to compare MPV, NLR, and PLR between patients with BD and healthy controls, and to evaluate these parameters in BD according to disease activity and thrombosis. Results In total, 14 studies were included. MPV was not higher in the BD group than in the control group (standardized mean difference [SMD], 0163; 95% confidence interval [CI], −0.125 to 0.451; P = 0.268), while NLR was significantly higher in the BD group than in the control group (SMD, 1.176; 95% CI, 0.392‐1.960, P = 0.003) and PLR showed a non‐significant trend of association with BD (SMD, 0.441; 95% CI, −0.025 to 0.907, P = 0.063). MPV did not differ between patients with active and inactive BD (SMD, −0.129; 95% CI, −0.323 to 0.085, P = 0.191), and between patients with BD with and without thrombosis (SMD, 0.231; 95% CI, −0.155 to 0.617, P = 0.241). Conversely, NLR was significantly higher in patients with active BD than in those with inactive BD (SMD, 1.774; 95% CI, 0.179‐3.368, P = 0.029), but not significantly higher in patients with BD with thrombosis than in those without thrombosis (SMD, 0.258; 95% CI, −0.277 to 0.792, P = 0.345). Conclusions This finding suggests that NLR may be a potential index to evaluate the disease activity of BD, although there are limitations of small number of studies and heterogeneity of individual characteristics.

Predictive value of haematologic parameters in diagnosis of testicular torsion: Evidence from a systematic review and meta‐analysis

“…In the last few years, haematologic parameters such as NLR and PLR have been identified to have predictive value in the diagnosis and prognosis of many diseases. Some studies have reported that these haematologic parameters might have diagnostic value in many chronic diseases such as Behcet syndrome (Lee & Song, ), psoriasis (Paliogiannis et al, ), nonaffective psychosis (Mazza, Lucchi, Rossetti, & Clerici, ) and diabetic nephropathy (Chen et al, ). And several investigations have demonstrated that these haematologic parameters were associated with prognosis of many cancers such as oesophageal cancer (Yodying et al, ), prostate cancer (Guo et al, ) and hepatocellular carcinoma (Zheng et al, ).…”

Manifestations, clinical course and prognostic markers in cutaneous polyarteritis nodosa

“…Other predictive factors included the presence of CRP and ANC. Derived indexes, such as NLR [36,37] and SII [38] have previously been used as prognostic markers for other inflammatory and autoimmune conditions, as well as in the context of malignant disease, and were also associated with an increased risk of relapse. In our study population, ulceration at presentation was the strongest predictor of recurrence (OR 18.6), and elevated pre‐treatment values of ESR, CPR, ANC, NLR and SII were also associated with a poor prognosis in terms of recurrence.…”

Prognostic Value of Systemic Inflammatory Indices, NLR, PLR, and MPV, for Predicting 1-Year Survival of Patients Undergoing Cytoreductive Surgery with HIPEC

“…The MPV is the mean size of platelets in the serum and reflects the rate and stimulation of platelet production [31]; it is regularly measured using blood count analyzers. Although the role of MPV levels in inflammatory process responses has been investigated in the literature, it remains less studied compared with NLR and PLR [31,32,33]. High-volume platelets have been reported to be critically involved in the infiltration of inflamed tissue [34].…”