Mean platelet volume in diagnosis of gestational diabetes

Çelikel, Erçin Erdem; Kurt, Sefa; Töz, Emrah; Yurtkul, Azra Arici; Gürbüz, Tutku; Taşyurt, Abdullah

doi:10.5835/jecm.omu.30.04.002

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…6 There was no association of plateletcrit with GDM patients in the study and similar results were also observed by Erikçi et al whereas Ahmet et al noted it to be slightly higher in patients with GDM. There was no association between platelet distribution width and GDM and similar results were elicited by Muhammet et al and Erikçi et al 4,7 In the study, no significant association was found between Hemoglobin and Hematocrit values with GDM and similar findings have been reported by Erikçi et al and Çelikel et al 4,8 On performing Spearman's regression analysis, there was a positive correlation between mean platelet volume and the value of glucose challenge test in the present study which has not been reported in previous studies. An inverse correlation between platelet count and value of glucose challenge test was also noted.…”

Section: Discussionsupporting

confidence: 87%

Association between Mean Platelet Volume and Gestational Diabetes Mellitus: A Case Control Study

Chandra,

Shetty

2023

Journal of South Asian Federation of Obstetrics and Gynaecology

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Aims: Gestational diabetes mellitus (GDM), one of the most prevalent and notorious medical disorders complicating pregnancy, is known to be associated with chronic low-grade inflammation which triggers endothelial injury and platelet activation. Mean platelet volume (MPV) has been hypothesized to be higher in GDM which may aid in early diagnosis and appropriate management of this complication. The aim of our study was to determine whether an association exists between MPV and the diagnosis of GDM and to compare various platelet indices in pregnant women with and without GDM. Materials and methods: All participants underwent a 50 gm glucose challenge test. If the 1 hour blood glucose level was = >140 mg/dL, these women were further subjected to a 100 gm oral glucose tolerance test which was interpreted according to the Carpenter and Coustan criteria. Women diagnosed with GDM were considered as cases (N = 73) and those with a negative screening test as controls (N = 73). Other platelet parameters were measured and then compared between the two groups. Results: The difference in MPV (p = < 0.001) and platelet count (p = 0.01) between cases and controls was found to be statistically significant. Pregnant women with GDM had a significantly higher MPV and lower platelet count. In addition, a statistically significant positive correlation was found between the GCT value and the MPV and an inverse correlation was noted between the GCT value and the platelet count. Conclusion: A significant difference between the values of MPV and platelet count in patients with GDM as compared with healthy pregnant women, at the time of diagnosis, aids in supporting evidence that mean platelet volume may be used as a marker for GDM. A positive correlation between MPV and value of GCT and an inverse relationship between the platelet count and GCT values further suggests that these markers may also be used to study disease severity and worse blood sugar derangements may be expected when they are deranged. Clinical significance: Our study has proven that the value of MPV in patients with a fresh diagnosis of GDM lies in the high normal range, when compared with healthy matched controls. This and the knowledge of differences in other platelet parameters would help not only in prediction and early diagnosis of pregnant women with GDM but also provide a tool to better predict complications and improve maternal and neonatal outcomes.

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Section: Discussionsupporting

confidence: 87%

Association between Mean Platelet Volume and Gestational Diabetes Mellitus: A Case Control Study

Chandra,

Shetty

2023

Journal of South Asian Federation of Obstetrics and Gynaecology

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“…Lower MPV values in GDM patients as compared to healthy women were the most important finding of our study, especially in light of the fact that in most previous studies MPV values in GDM patients values were either higher (17,19,20), or the same as in healthy controls (16). Currently, the MPV test is not regarded as a marker of platelet function because of the test results may be affected by the following factors: time from obtaining the specimen until the analysis, the use of anticoagulated tubes, and the lack of a standardized method of measurement (21,22).…”

Section: Discussionsupporting

confidence: 64%

A Study of Inflammatory Markers in Gestational Diabetes Mellitus

Mertoğlu¹,

Günay²,

Güngör³

et al. 2019

Gynecol Obstet Reprod Med

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Objective: Gestational diabetes mellitus is a common disorder of carbohydrate metabolism, with onset or first recognition during pregnancy, resulting in hyperglycemia of variable severity. Insulin resistance and chronic subclinical inflammation are the underlying mechanisms of the disease. Soluble interleukin-2 receptor, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio are the markers of inflammatory disease processes such as type 1 and 2 diabetes mellitus, hepatitis, and neoplasms.Study Design: In our study, we measured complete blood count, serum soluble interleukin-2 receptor, serum glucose in blood samples from 52 women with gestational diabetes mellitus and 50 pregnant women with normal glucose tolerance. Pregnant women which were tested for oral glucose tolerance test (75 gr load) between 24 and 28 weeks of pregnancy were selected for the study. Gestational diabetes mellitus was defined according to the criteria provided by the National Institute for Health and Care Excellence. Results: In terms of age, gestational diabetes mellitus patients (mean±SD; 31±6 years) were older than controls (mean±SD; 25±5.3 years). Mean platelet volume values were lower in gestational diabetes mellitus patients (mean±SD; 10.3±1.4 fL) as compared to normal glucose tolerance group (mean±SD; 10.8±1fL). No statistically significant differences in serum glucose concentration, white blood cell count, neutrophil count, lymphocyte count, hemoglobin concentration, platelet count, neutrophil-to-lymphocyte ratio value, platelet-to-lymphocyte ratio value, and serum soluble interleukin-2 receptor concentration were found. Conclusion: This study did not reveal an increase in the inflammatory markers, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and serum soluble interleukin-2 receptor, in gestational diabetes mellitus. The mean platelet volume values were observed to be lower in gestational diabetes mellitus patients.

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Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Zhou

Chen

Sun

et al. 2018

Journal of Diabetes Research

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Aim To evaluate the association between mean platelet volume (MPV) and gestational diabetes mellitus (GDM). Methods A systematic literature search was performed in PubMed, EMBASE, Web of Science, and The Cochrane Library up to 4 September 2017. Pooled standardized mean differences (SMD) and 95% confidence interval (CI) were calculated using a random-effect model. Results Nineteen studies comprising 1361 GDM patients and 1911 normal pregnant women were included. MPV was increased in GDM patients when compared with healthy pregnant women (SMD: 0.79; 95% CI: 0.43–1.16; P < 0.001). Subgroup analyses revealed that such trend was consistent in the third-trimester (SMD: 1.35; 95% CI: 0.72–1.98), Turkish (SMD: 0.81; 95% CI: 0.43–1.19), and Italian (SMD: 2.78; 95% CI: 2.22–3.34) patients with GDM and the patients diagnosed based on Carpenter and Coustan criteria (SMD: 1.04; 95% CI: 0.42–1.65). Significantly higher MPV also were observed within cross-sectional studies (SMD: 0.99; 95% CI: 0.49–1.49). Remarkable between-study heterogeneity and potential publication bias were observed in this meta-analysis; however, sensitivity analysis indicated that the results were not unduly influenced by any single study. Conclusions GDM patients are accompanied by increased MPV, strengthening the clinical evidence that MPV may be a predictive marker for GDM.

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Mean platelet volume in diagnosis of gestational diabetes

Abstract: Article History

Cited by 3 publications

References 16 publications

Association between Mean Platelet Volume and Gestational Diabetes Mellitus: A Case Control Study

Association between Mean Platelet Volume and Gestational Diabetes Mellitus: A Case Control Study

A Study of Inflammatory Markers in Gestational Diabetes Mellitus

Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

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