Mean Platelet Volume in Obese Adolescents with Nonalcoholic Fatty Liver Disease

Arslan, Nur; Makay, Balahan

doi:10.1515/jpem.2010.130

Cited by 42 publications

(37 citation statements)

References 35 publications

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“…obese adolescents had higher MPV but a lower platelet count. 19 Atorvastatin administration significantly decreased MPV in obese atorvastatin treated rats of our study. Effect of statins in reducing atherothrombotic events has been published widely in bio medical literature, and statins are known to decrease platelet reactivity; however, this effect on newly proposed platelet reactivity marker (i.e.…”

Section: Discussionsupporting

confidence: 50%

Effect of Obesity and Statin; Newly Emerging Cardiovascular Risk Factor; Mean Platelet Volume in Male and Female Sprague Dawley Rats.

Shabbir

Hussain

Rajput

et al. 2017

TPMJ

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ABSTRACT… Objectives:To observe the effect of obesity and subsequent atorvastatin administration on MPV in high fat diet induced obese male and female Sprague Dawley rats. Study Design: Randomized control trial (RCT). Setting: Department of Physiology, Army Medical College, Rawalpindi. Animal procurement and blood sampling was done at National Institute of Health (NIH), Islamabad and biochemical assays were performed at Centre for Research in Experimental and Applied Medicine (CREAM), Army Medical College, Rawalpindi. Period: The study was completed in 12 months. Material and Methods: Ninety healthy Sprague Dawley (male and female) rats were purchased and divided randomly into three equal groups. Rats in normal control group (Group I) were given normal chow diet for three weeks. Rats in obese control group (Group II) were given high fat diet for three weeks. Rats in obese treated group (Group III) were administered atorvastatin for three weeks in a dose of 10 mg/kg/day orally by gavage method after obesity induction. Terminal sampling was done at the end of the study by intra-cardiac puncture. MPV is a part of blood complete picture that was analysed by KX 21 Sysmex Hematology Analyzer. Results: High fat diet induced obesity resulted in a significant (p < 0.05) increase in MPV. The MPV was significantly (p < 0.05) decreased after atorvastatin administration. The result was comparable for both genders. Conclusions: Obesity increases MPV and hence the risk of adverse cardiovascular outcome. Atorvastatin apart from its known lipid lowering effect, decreases MPV and can play a beneficial role in decreasing cardiovascular morbidity and mortality.Key words: Obesity, Mean platelet volume, statins, rats, cardiovascular risk, platelet reactivity.

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Section: Discussionsupporting

confidence: 50%

Effect of Obesity and Statin; Newly Emerging Cardiovascular Risk Factor; Mean Platelet Volume in Male and Female Sprague Dawley Rats.

Shabbir

Hussain

Rajput

et al. 2017

TPMJ

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“…Arslan and Makay have demonstrated that MPV levels were higher in obese adolescents with non-alcoholic fatty liver when compared with healthy controls, and other obese patient groups [17]. However, Kilciler et al reported that any significant difference was not found between the patients with non-alcoholic fatty liver disease as for MPV levels [18].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil lymphocyte ratio in obese adolescents

Aydın

Yılmaz

Donma

et al. 2015

North Clin Istanbul

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OBJECTIVE:Obesity is a growing health problem in most of the developed countries. It is associated with many chronic diseases, affecting particularly endocrine and cardiovascular systems. Inflammation plays a key role in pathophysiology of obesity. In this study, we aimed to investigate the inflammation status in obese children using neutrophil/lymphocyte ratio.METHODS:In this study 130 obese and 57 healthy children were assessed retrospectively. According to Centers for Disease Control 2000 (CDC) BMI percentiles for childhood and adulthood, 85–95 percentile was considered as overweight and >95 percentile as obese.RESULTS:Lymphocyte/neutrophil ratios in the obese group were significantly higher compared to those in healthy controls (p=0.03 and p=0.045, respectively). Neutrophil/lymphocyte ratio and CRP level in the obese group were significantly higher compared to those in healthy controls (p=0.02 and p=0.00, respectively). Thrombocyte/lymphocyte ratios were not significantly different between two groups (p=0.156).CONCLUSION:It is possible that childhood obesity which has been increasingly prevalent recently triggers the pathogenesis of atherosclerosis during the early years of life. Increased neutrophil/lymphocyte ratio might be associated with the severity of inflammation which plays a role in the early stages of atherosclerosis. Therefore, taking childhood obesity under control using diet and other treatment methods will prevent mortality and morbidity in the elderly.

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“…In a study of 128 obese adolescents, MPV was significantly higher in obese patients with NAFLD compared with obese patients without NAFLD or controls. This indicates that children with NAFLD have higher CV risk; however, correlation with liver histology was not examined as the diagnosis of NAFLD was made based on ultrasound findings and the presence of elevated liver enzymes [76]. …”

Section: Nafld and Systemic Inflammationmentioning

confidence: 99%

Atherogenic dyslipidemia and cardiovascular risk in children with nonalcoholic fatty liver disease

Alkhouri

Carter–Kent

Elias

et al. 2011

Clinical Lipidology

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Nonalcoholic fatty liver disease is now regarded as the most common form of chronic liver disease in adults and children. The close association between nonalcoholic fatty liver disease (NAFLD) and the metabolic syndrome has been extensively described. Moreover, a growing body of evidence suggest that NAFLD by itself confers a substantial cardiovascular risk independent of the other components of the metabolic syndrome. Given the significant potential for morbidity and mortality in these patients, and the large proportion of both pediatric and adult population affected, it is important that we clearly define the overall risk, identify early predictors for cardiovascular disease progression, and establish management strategies. In this article, we will focus on current data linking NAFLD and the severity of liver damage present in children with cardiovascular risk.

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Mean Platelet Volume in Obese Adolescents with Nonalcoholic Fatty Liver Disease

Cited by 42 publications

References 35 publications

Effect of Obesity and Statin; Newly Emerging Cardiovascular Risk Factor; Mean Platelet Volume in Male and Female Sprague Dawley Rats.

Effect of Obesity and Statin; Newly Emerging Cardiovascular Risk Factor; Mean Platelet Volume in Male and Female Sprague Dawley Rats.

Neutrophil lymphocyte ratio in obese adolescents

Atherogenic dyslipidemia and cardiovascular risk in children with nonalcoholic fatty liver disease

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