Mean Platelet Volume is Associated with Diabetic Macular Edema in Patients with Type-2 Diabetes Mellitus

Tetikoğlu, Mehmet; Aktaş, Serdar; Sağdık, Hacı Murat; Yigitoglu, Sıla Tasdemir; Özçura, Fatih

doi:10.3109/08820538.2016.1157612

Cited by 12 publications

(20 citation statements)

References 18 publications

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“…In our study diabetic ZDF rats had increased MPV values in comparison with the healthy lean control [54]. In diabetic patients there is usually higher value of PDWc-the hematological parameter that presents an indicator of variation in platelets' size and activity [79,82]. In our previous research [83], we observed that the rise in the secondary symptoms of T2DM complications caused by high-energy diet was accompanied with disturbed hematological parameters.…”

Section: Hematological Parameters Of Zdf Ratssupporting

confidence: 51%

“…Usually diabetic patients have increased MPV values [79] correlated with a large thrombocyte size that are more reactive and aggregable [77] which can upset hemostatic system during the diabetic state [80]. In diabetes the risk of retinopathy onset increases with higher MPV [79,81]. In our study diabetic ZDF rats had increased MPV values in comparison with the healthy lean control [54].…”

Section: Hematological Parameters Of Zdf Ratssupporting

confidence: 45%

“…Increased MPV can be an independent risk factor for arterial thrombotic events such as myocardial infarction and cerebral thromboembolism [78]. Usually diabetic patients have increased MPV values [79] correlated with a large thrombocyte size that are more reactive and aggregable [77] which can upset hemostatic system during the diabetic state [80]. In diabetes the risk of retinopathy onset increases with higher MPV [79,81].…”

Section: Hematological Parameters Of Zdf Ratsmentioning

confidence: 99%

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Zucker Diabetic Fatty Rats for Research in Diabetes

Capcarová¹,

Kalafová²

2020

Animal Models in Medicine and Biology

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The rising incidence of diabetes mellitus (DM) worldwide presents a global public health problem. DM is classified into two main groups: type 1 (T1DM) and type 2 (T2DM). T1DM requires insulin treatment. T2DM is complex, heterogeneous, polygenic disease defined primarily by insulin resistance, ongoing hyperglycemia, and β cells' dysfunction. For research in diabetes, an appropriate experimental model reflecting symptoms and complications of human T2DM is required for understanding the pathogenesis, molecular nature, and the possibilities of the treatment. Among the many animal models, rodent models that develop DM spontaneously are frequently used in the studies due to their similarity to the humans and economic effectiveness. This work gives a detailed overview of the literature, covering the characteristic of DM, its symptoms and complications, the description of Zucker diabetic fatty (ZDF) rats as an appropriate model for research in T2DM, and the possibility of the treatment.spontaneously diabetic Tori (SDT) rats, Kuo Kondo (KK) mice, ob/ob+/+ mice, and db/db+/+ mice [84]. GK rats are nonobese Wistar substrain which develops T2DM early [86]. Male OLETS rats suffer from diabetes at 18-25 weeks of age. The symptoms include polyphagia, mild obesity, hypertriglyceridemia, hyperinsulinemia, and impaired glucose tolerance in 16 weeks of age [87]. Tori SDT rat is inbred strain of Sprague-Dawley rat. Male individuals have high glucose levels by 20 weeks, pancreatic islet histopathology, hemorrhage in pancreatic islets, and inflammatory cell infiltration with fibroblasts, prior to diabetes glucose intolerance with hypoinsulinemia [88].KK mice are a polygenic model of obesity and T2DM. They are characterized by insulin resistance, hyperinsulinemia, and hyperphagia [89]. The ob/ob+/+ mice carry a mutation in the leptin gene, manifested as obesity, hyperglycemia, impaired glucose intolerance, and hyperinsulinemia [90]. The db/db+/+ mice have a leptin receptor mutation, are spontaneously hyperphagic, and suffer from obesity, hyperglycemia, hyperinsulinemia, and insulin resistance within the first month of life [91]. The advantages of ZDF rats in diabetes research are mainly due to the fact that it is a spontaneous model for T2DM research. It shows characteristics such as hyperglycemia, obesity, hyperphagia, polyuria, insulin disorders, and dyslipidemia due to the mutation in the leptin receptor gene and provides an appropriate model for common human T2DM. Moreover, these rats are calm and dispassionate; the handling and manipulation with them is comfortable.

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Section: Hematological Parameters Of Zdf Ratssupporting

confidence: 51%

Section: Hematological Parameters Of Zdf Ratssupporting

confidence: 45%

Section: Hematological Parameters Of Zdf Ratsmentioning

confidence: 99%

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Zucker Diabetic Fatty Rats for Research in Diabetes

Capcarová¹,

Kalafová²

2020

Animal Models in Medicine and Biology

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“…Of the 68 studies, 9 articles were excluded since control group’s subjects were not DM patients, but healthy people, and 11 articles were removed owing to the lack of available data. Finally, 48 articles with 9118 patients were enrolled in this meta-analysis [ 21–23 , 29–73 ].…”

Section: Resultsmentioning

confidence: 99%

“…However, in retrospect, the conclusions regarding the relationship of NLR, MPV, and PDW to the development and progression of DR and DN were conflicting [ 21–23 ]. One of the reasons for the inconsistency might be that the sample size was small in a single study and the power of statistical results was challenged.…”

Section: Introductionmentioning

confidence: 99%

The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis

Liu

Li³

et al. 2018

Bioscience Reports

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The aim of the present study was to investigate the correlation of neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), and platelet distribution width (PDW) with diabetic nephropathy (DN) and diabetic retinopathy (DR). We searched for eligible studies from PubMed, Embase, Web of Science, and CNKI up to 1 December 2017. Standardized mean difference (SMD) was calculated with a confidence interval (CI) of 95%. A total of 48 studies were included in our meta-analysis. Compared with patients with type Ⅱ diabetes mellitus (T2DM) and without DR, NLR, MPV, and PDW were higher in patients with DR (SMD = 0.77; 95% CI: 0.49–1.05; P<0.001; SMD = 0.68; 95% CI: 0.36–0.99; P<0.001; SMD = 0.52; 95% CI: 0.28–0.76; P<0.01). Compared with patients with T2DM and without DN, NLR, MPV, and PDW were higher in patients with DN (SMD = 0.63; 95% CI: 0.43–0.83; P<0.001; SMD = 0.81; 95% CI: 0.36–1.25; P<0.001; SMD = 0.70; 95% CI: 0.50–0.90; P<0.001). We also found that MPV was strongly associated with the severity of DR, and NLR was closely related to the degree of DN. Our findings indicated that NLR, MPV, and PDW could be recommended as inexpensive diagnostic biomarkers for DN and DR. However, considering several limitations in the present study, further high-quality clinical studies should be performed to investigate the relationship of NLR, MPV, and PDW to DN and DR.

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Predictive Effect of Mean Platelet Volume in Patients with Portal Vein Thrombosis: A Meta-analysis of Case-control Studies

Lin

Fan

et al. 2018

CURR MED SCI

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Mean platelet volume (MPV) is an early marker of platelet activation. Larger platelets, compared to small ones, increase platelet adhesion and aggregation, and present a higher thrombotic activity. Some studies have explored the association between MPV and the morbidity of portal vein thrombosis (PVT). The aim of this study was to evaluate the predictive effect of MPV in patients with PVT by a meta-analysis. We searched Pubmed, Web of Science, SCOPUS, OVID, CNKI and CBMD from database inception to September 13,2017. Seven studies in accordance with selection criteria were included. The extraction of basic data was independently conducted by two reviewers. The mean difference in MPV between PVT patients and controls were pooled with weighted mean difference (WMD) and 95% confidence interval of 0.88 fl (95% CI: 0.61-1.15). A random-effect model was chosen for an obvious heterogeneity in the pooling (Chi-square=27.12, df=6, P<000l, I=77.9%). The sources of heterogeneity were from the difference of primary disease of participants and portal vein diameter. Taken together, our results reveal that MPV is a predictive indicator in patients with PVT.

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Mean Platelet Volume is Associated with Diabetic Macular Edema in Patients with Type-2 Diabetes Mellitus

Abstract: High MPV values may be an important risk factor for the development of PDR and DME in patients with diabetic retinopathy.

Cited by 12 publications

References 18 publications

Zucker Diabetic Fatty Rats for Research in Diabetes

Zucker Diabetic Fatty Rats for Research in Diabetes

The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis

Predictive Effect of Mean Platelet Volume in Patients with Portal Vein Thrombosis: A Meta-analysis of Case-control Studies

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