Mean Platelet Volume may be Reflects the Disease Activity of Ulcerative Colitis

Güçlü, Mustafa; Sakallı, Hakan; Yakar, Tolga

doi:10.29333/ejgm/82865

Cited by 6 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The statistically significant declined MPV in CD patients observed in the present study is in accordance with findings of prior studies [9,10], suggesting that MPV may be helpful in clinical practice [34,35]. …”

Section: Discussionsupporting

confidence: 93%

Mean platelet volume: a controversial marker of disease activity in Crohn’s disease

et al. 2012

View full text Add to dashboard Cite

BackgroundWe investigated and compared the capacity of mean platelet volume (MPV) and other inflammatory markers in detecting Crohn’s disease (CD) activity and differentiating CD patients from healthy controls.MethodsMPV, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and white blood cells were measured in 61 CD patients and 50 healthy subjects. Disease activity was assessed by the Crohn’s Disease Activity Index.ResultsA significant decrease in MPV was noted in patients with CD compared with healthy controls (P <0.0001), but statistical difference was not found between active and inactive CD groups. In CD, no significant correlation was found between MPV and other inflammatory markers. The overall accuracy of MPV (cutoff: 10.35 fl), CRP (cutoff: 4.85 mg/dl) and ESR (cutoff: 8.5 mm/hour) in differentiating CD patients from healthy controls was 76.6%, 65.8% and 72.1% respectively. The overall accuracy of CRP (cutoff: 4.95 mg/dl) and ESR (cutoff: 16.5 mm/hour) in determination of active CD was 80.3% and 73.8%.ConclusionsMPV declined in CD patients compared with healthy subjects. MPV had the best accuracy in determination of CD patients and healthy controls. MPV did not show a discriminative value in disease activity.

show abstract

Section: Discussionsupporting

confidence: 93%

Mean platelet volume: a controversial marker of disease activity in Crohn’s disease

et al. 2012

View full text Add to dashboard Cite

show abstract

“…On the bases of obtained results MPV indicator can be regarded as a marker of exacerbation of inflammation of colonic mucosa in patients with UC. Güçlü et al research [ 23 ] and our own results confirm that the number of blood platelets increases and the MPV decreases in the active UC. Large platelets “megathrombocytes” (highly reactive cells that are actively involved in the inflammatory response) are gradually consumed to form platelet aggregates and different cell complexes [ 23 – 24 ].…”

Section: Discussionsupporting

confidence: 83%

“…Güçlü et al research [ 23 ] and our own results confirm that the number of blood platelets increases and the MPV decreases in the active UC. Large platelets “megathrombocytes” (highly reactive cells that are actively involved in the inflammatory response) are gradually consumed to form platelet aggregates and different cell complexes [ 23 – 24 ]. In addition, activated platelets contribute to the formation of microthrombosis in the intestinal microcirculation.…”

Section: Discussionsupporting

confidence: 83%

Markers of inflammation and influence of nitric oxide on platelet activation in the course ofulcerative colitis

et al. 2017

View full text Add to dashboard Cite

Ulcerative colitis is a non-specific inflammatory bowel disease of unknown etiology. We investigated whether severe form of ulcerative colitis may lead to increased number of platelets, changes in platelet parameters and their activation. To address our objectives, we measured concentrations of nitric oxide and markers of inflammation. We found increased number of low-volume platelets in a group of affected patients. However, their activity was not as high as expected. In addition to that we observed eight times higher concentration of nitric oxide in patients suffering from ulcerative colitis than in healthy individuals. Besides, severe form of the disease manifested itself with increased concentrations of interleukine 6, matrix metalloproteinase-9 and neopterin. Based on the results we propose that high amounts of nitric oxide inhibit platelet activation in severe form of ulcerative colitis. Moreover, our observations regarding interleukine 6, matrix metalloproteinase-9 and neopterin suggest that they may become useful markers of active form of ulcerative colitis.

show abstract

“…Yüksel et al [41] UC (61) 27 Reduced MPV in UC compared to HC Inverse correlation between MPV and disease activity Inverse correlation between MPV and disease extent Järemo et al [39] UC (18), 12 Reduced MPV in UC patients compared to HC CD (9) Inverse correlation between MPV and disease activity Güçlü et al [42] UC (41) (-) Reduced MPV in active compared to non-active disease Voudoukis et al [46] UC (91), CD (107) 102 Reduced MPV in IBD patients compared to HC Correlation of MPV with Hb and sTfR Öztürk et al [45] UC (103), CD (72) 40 Reduced MPV in IBD compared to HC MPV decreases after remission in UC MPV increases after remission in CD Kapsoritakis et al [40] UC (93), CD (66) 38 Correlation between MPV and disease activity indices Correlation between MPV and disease extent Kayahan et al [44] UC (37) 20 Correlation between MPV and disease activity indices Reduced MPV in UC compared to HC Liu et al [43] CD ( PLT granular products, such as P-selectin, GP Ⅱb/Ⅲa, CD40L, and GP53, are incorporated into the cytoplasmic membrane, giving them a more adhesive and interacting phenotype. Moreover, PLT during activation develop receptors for chemokines, cytokines, and complement components, enabling them to participate in various inflammatory cascades in IBD [1] (Figure 2).…”

Section: Disease (N ) Hc (N ) Mpv Correlationsmentioning

confidence: 99%

“…In IBD patient studies a MPV value decrease has long been observed [39] which has been inversely correlated with endoscopic and disease activity indices, such as C-reactive protein and erythrocyte sedimentation rate [40][41][42][43][44] . This MPV reduction can be attributed to the decreased circulating reticulated PLT number that was found in patients with active UC compared to inactive and healthy control subjects [44] .…”

Section: Platelet Changes In Ibdmentioning

confidence: 99%

Multipotent role of platelets in inflammatory bowel diseases: A clinical approach

Voudoukis¹

2014

WJG

View full text Add to dashboard Cite

There is evidence that inflammatory bowel diseases (IBD) combine both inflammation and coagulation in their pathogenesis and clinical manifestations. Although platelets (PLT) are well known for their role in hemostasis, there are a rising number of studies supporting their considerable role as inflammatory amplifiers in chronic inflammatory conditions. IBD are associated with several alterations of PLT, including number, shape, and function, and these abnormalities are mainly attributed to the highly activated state of circulating PLT in IBD patients. When PLT activate, they increase in size, release a great variety of bio-active inflammatory and procoagulant molecules/particles, and express a variety of inflammatory receptors. These inflammatory products may represent a part of the missing link between coagulation and inflammation, and can be considered as possible IBD pathogenesis instigators. In clinical practice, thrombocytosis is associated both with disease activity and iron deficiency anemia. Controlling inflammation and iron replacement in anemic patients usually leads to a normalization of PLT count. The aim of this review is to update the role of PLT in IBD and present recent data revealing the possible therapeutic implications of anti-PLT agents in future IBD remedies.

show abstract

Mean Platelet Volume may be Reflects the Disease Activity of Ulcerative Colitis

Abstract: Aim:To determine the relation between the disease activity of ulcerative colitis and mean platelet volume (MPV)

Cited by 6 publications

References 33 publications

Mean platelet volume: a controversial marker of disease activity in Crohn’s disease

Mean platelet volume: a controversial marker of disease activity in Crohn’s disease

Markers of inflammation and influence of nitric oxide on platelet activation in the course ofulcerative colitis

Multipotent role of platelets in inflammatory bowel diseases: A clinical approach

Contact Info

Product

Resources

About