Mean platelet volume may indicate early diagnosed gastric cancer based on inflammation

Demırkol, Sait; Balta, Şevket; Küçük, Uğur; Çelik, Turgay

doi:10.3109/09537104.2013.799646

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…Notably, a high MPV value has been observed in patients with cardiovascular risk factors including diabetes mellitus, hypertension, hypercholesterolemia, smoking and obesity ( 6 - 8 ). Furthermore, it has been shown the diagnostic role of MPV, based on being inflammatory marker, in the patients with Behçet’s disease and malignancy ( 9 , 10 ). In addition, the prognostic value of MPV for predicting long-term mortality after PCI has been demonstrated ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of mean platelet volume in patients undergoing elective percutaneous coronary intervention

Seyyed-Mohammadzad¹,

Eskandari²,

Rezaei³

et al. 2015

Anadolu Kardiyol Derg

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Objective:We sought to determine the role of mean platelet volume (MPV) for predicting long-term outcomes of elective percutaneous coronary intervention (PCI).Methods:On the basis of retrospective cohort study, we collected characteristics of 680 patients undergoing elective PCI from October 2005 to August 2010. The patients who had preoperative MPV were assessed for developing major adverse cardiac events (MACE) during 1-year follow-up. They were categorized into two groups including MPV <9.6 fL (n=89) and MPV ≥9.6 fL (n=92). Data were analyzed using t-test, chi-square test, Pearson correlation, receiver operating characteristic (ROC) curve and logistic regression.Results:One-hundred eighty one patients (26.6%) met inclusion criteria. The MACE was observed in 29 patients (16%); and its rate in low- and high-MPV groups was 11.2% and 20.7%, respectively (p=0.084). MPV was significantly higher in the patients with left ventricular ejection fraction (LVEF) <40% compared with that of ≥40% (p<0.001). There were a significant and negative correlation between MPV and platelet count (r=-0.305, p<0.001), and significant and positive correlations between MPV and platelet distribution width (PDW) and platelet large cell ratio (P-LCR) (r=0.615, p<0.001 and r=0.913, p<0.001; respectively). The best MPV cut-off point was 9.25 fL; the sensitivity and specificity were 79% and 38%, respectively. Elevated MPV was the best predictor of MACE at 1-year follow-up (OR=11.359, 95% CI 2.481-51.994, p=0.002).Conclusion:The results indicate that preoperative MPV is an independent predictor of the MACE at 1-year follow-up in the patients undergoing elective PCI. Moreover, it may be useful for risk stratification in such cases.

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Section: Introductionmentioning

confidence: 99%

Prognostic value of mean platelet volume in patients undergoing elective percutaneous coronary intervention

Seyyed-Mohammadzad¹,

Eskandari²,

Rezaei³

et al. 2015

Anadolu Kardiyol Derg

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“…N/L ratio itself alone without other overt inflammatory markers may not accurately provide information about the prognosis of the patient 6. So, the N/L ratio should be evaluated together with other inflammatory markers like mean platelet volume7 and red cell distribution width 8. We believe that these findings will guide further studies about mean platelet volume as a surrogate marker of early diagnosis in patients with GC.…”

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confidence: 99%

Neutrophil-to-Lymphocyte Ratio in Prognosis of Gastric Cancer

et al. 2013

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“…Furthermore, MPV is linked with peripheral artery disease and stroke, all of which are related to atherosclerosis on the basis of inflammation [2,7]. It can also be affected by rheumatoid arthritis [8,9], osteoarthritis [10], Behçet's disease [11], malignancy [12] and medications such as anticoagulant therapy, statins. So, if the authors had mentioned these factors, it might be useful.…”

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confidence: 99%

Mean platelet volume and glomerular filtration rate: Two important risk determinants in coronary artery disease

et al. 2013

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Mean platelet volume may indicate early diagnosed gastric cancer based on inflammation

Cited by 4 publications

References 14 publications

Prognostic value of mean platelet volume in patients undergoing elective percutaneous coronary intervention

Prognostic value of mean platelet volume in patients undergoing elective percutaneous coronary intervention

Neutrophil-to-Lymphocyte Ratio in Prognosis of Gastric Cancer

Mean platelet volume and glomerular filtration rate: Two important risk determinants in coronary artery disease

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