Mean platelets volume and neutrophil to lymphocyte ratio as predictors of stroke

Abstract

Background Mean platelets volume (MPV) is a marker, which indicates platelet function, and is a potential link between inflammation and thrombosis. Previous studies have found a relation between high MPV levels and high risk of stroke. Another factor that has been associated with the risk of stroke is neutrophil to lymphocyte ratio (NLR). Several studies have reported an association between increased NLR and increased risk of cerebrovascular disease. It was found that NLR levels have a relation to the prognosis as well. Since both NLR and MPV have been associated with increased risk of cardiovascular disease, together they may predict the risk of stroke and the prognosis with higher sensitivity and specificity. Methods This is a descriptive retrospective study. Data were gathered from medical records of patients who applied the Ziv medical center and were diagnosed with stroke. Stroke severity was evaluated using the NIHSS (national institutes of health stroke scale). MPV and NLR levels of patients with stroke were compared to those of 30 healthy individuals. Results Neutrophil to lymphocyte ratio levels were found significantly higher in patients with stroke compared with healthy individuals. NLR was also found higher in patients with moderate/severe stroke compared with those with minor stroke. No association was found between MPV level, the risk of stroke, and stroke prognosis. Moreover, an interaction effect between MPV and NLR level was not found. Conclusion Neutrophil to lymphocyte ratio is a good predictive factor of stroke and stroke prognosis. Further prospective studies are needed to establish the relationship between the MPV level and the risk of stroke. NLR and MPV interaction effect can be tested again in the future after establishing the association between MPV, the risk of stroke, and stroke prognosis.

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

“…Seventeen results of the 27 studies revealed that patients with stroke had higher MPV than controls [10,12,25,27,28,34,35,39,41-43, [46][47][48]50]. Ten studies found no difference in MPV between patients and controls [14,15,28,29,35,36,38,45,49], and two studies demonstrated a higher MPV in the control group (Table I, Supplementary Table VI) [13,40]. The mean MPV for all publications was 9.8 fL (95% CI 9.4-10.1) for patients and 9.2 fL (95% CI, 8.8-9.6) for controls.…”

The relationship between platelet indices and ABO blood groups in healthy adults

“…These different markers give information about platelet sizes and platelet functions . During activation, the platelet size tends to increase, and the platelets become hemostatically more active than small platelets . MPV, usually used to measure the platelet size, is an important biomarker of platelet activation and function .…”

Can Blood Groups, Neutrophil-Lymphocyte Ratio and Mean Platelet Volume Predict Mortality in Critically Ill Patients Developing Acute Kidney Injury?

“…The reason why we had different results may be related to the fact that we included cases with a specific disease. In one study, Farah and Samra [36] compared NLR and MPV values between cases diagnosed with ischemic stroke and 30 healthy volunteers, and they found higher NLR values in cases with ischemic stroke compared to healthy volunteers, whereas they did not find difference in MPV values. Farah and Samra [36] proposed that NLR was a good predictor for stroke and prognosis of stroke, while MPV was not [36].…”