Measurement and correlation of solubility of Tetracycline hydrochloride in six organic solvents

Zhao, Yan; Wang, Yongli

doi:10.1016/j.jct.2012.08.007

Cited by 37 publications

(16 citation statements)

References 17 publications

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“…According to the solid-liquid phase equilibrium theory and the solute-solvent interactions, the local composition equation [18] could be simplified and expressed by equation (11):…”

Section: The Local Composition Model: Nrtl Modelmentioning

confidence: 99%

Solution thermodynamics of simvastatin in pure solvents and binary solvent mixtures

Yan

Yin

Jiang

et al. 2015

Fluid Phase Equilibria

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“…According to the solid-liquid phase equilibrium theory and the solute-solvent interactions, the local composition equation [18] could be simplified and expressed by equation (11):…”

Section: The Local Composition Model: Nrtl Modelmentioning

confidence: 99%

Solution thermodynamics of simvastatin in pure solvents and binary solvent mixtures

Yan

Yin

Jiang

et al. 2015

Fluid Phase Equilibria

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“…Increasing the ι-carrageenan to poly (vinyl alcohol) ratio in the hydrogels determines an increase in the drug release ratio for the first diffusion-controlled step for all three antibiotics (tetracycline hydrochloride (M w = 444.4; hydrodynamic radius of 7.98 nm, pKa 1 = 3.3, pKa 2 = 7.2 at 25 °C) [ 52 ], amoxicillin (M w = 365.4; hydrodynamic radius of 6.507; pKa 1 = 2.69; pKa 2 = 7.3 at 25 °C) [ 53 ], and gentamicin sulfate (M w = 516.6; hydrodynamic radius of 9.58 nm; pKa 1 = 10.18; pKa 2 = 12.55 at 25 °C) [ 54 ], due to the higher solvent penetration rate ( k D values, Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…For tetracycline hydrochloride, the conjugated trione system (involving the amide group) is responsible for pKa 1 = 3.3 [ 52 ]. The weakly basic conjugated phenolic enone system becomes involved at pH = 7.3, owing for a 25% decrease in the value of the tetracycline diffusion coefficients, compared to pH = 3.…”

Section: Resultsmentioning

confidence: 99%

Diffusion and Controlled Release in Physically Crosslinked Poly (Vinyl Alcohol)/Iota-Carrageenan Hydrogel Blends

et al. 2020

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This paper reports the obtaining of poly (vinyl alcohol) and ι-carrageenan blend hydrogels by physical crosslinking (consecutive freeze–thaw cycles). The two polymers were completely miscible in the weight ratio interval used in this study, as determined by solution viscometry data. Strong interactions through hydrogen bonding and forming of mixed interpolymer crystalline domains were observed, which are responsible for the formation of stable drug release-tunable matrices. The release profiles of three model antibiotic drugs (amoxicillin, tetracycline hydrochloride, and gentamicin sulfate) were assessed in a pH interval between 3 and 7.3. They were found to be strongly dependent on the drug chemistry, mesh size of the hydrogels, swelling mechanism, and pH of the release medium. A decrease of up to 40% in the release rates and up to 10% in the diffusion coefficients of the model drugs was registered with the increase in ι-carrageenan content.

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“…Besides its antibiotic properties, it has unique properties such as regulating immunity, preventing urinary tract infections, formation of new vessels called angiogenesis, growth, development, and wound healing, affecting inflammation and cell growth, and attractive usage areas as a model drug in drug delivery systems. 8 The different drug delivery systems such as dendrimers, micelles, liposomes, nanotubes have been widely used in controlled drug release until now. Carrier systems based on the fatty acid, which have unique properties for the treatment of intracellular bacterial infection, are quite attractive devices due to a natural component of the body.…”

Section: Introductionmentioning

confidence: 99%

Prevention of urinary infection through the incorporation of silver–ricinoleic acid–polystyrene nanoparticles on the catheter surface

et al. 2021

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Nosocominal infections associated with biofilm formation on urinary catheters cause serious complications. The aim of this study was to investigate the feasibility of the polyurethane (PU) catheter modified with tetracycline hydrochloride (TCH) attached Ag nanoparticles embedded PolyRicinoleic acid-Polystyrene Nanoparticles (PU-TCH-AgNPs-PRici-PS NPs) and the influence on antimicrobial and antibiofilm activity of urinary catheters infected by Escherichia coli and Staphylococcus aureus. For this purpose, AgNPs embedded PRici graft PS graft copolymers (AgNPs-PRici-g-PS) were synthesized via free radical polymerization and characterized by FTIR, HNMR and DSC. AgNPs-PRici-PS NPs were prepared and optimized by the different parameters and the optimized size of nanoparticle was found as about 150 ± 1 nm. The characterization of the nanoparticles and the morphological evaluation were carried out by FTIR and SEM. Short term stability of nanoparticles was realised at 4°C for 30 days. In vitro release profiles of TCH and Ag NPs were also investigated. The formation of biofilm on PU modified TCH-Ag NPs-PRici-PS NPs, was evaluated and the biocompatibility test of the nanoparticles was realized via the mouse fibroblast (L929) and mouse urinary bladder cells (G/G An1). This is the first time that TCH-AgNPs-PRici-PS NPs used in the modification of PU catheter demonstrated high antimicrobial and antibiofilm activities against the urinary tract infection.

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Measurement and correlation of solubility of Tetracycline hydrochloride in six organic solvents

Cited by 37 publications

References 17 publications

Solution thermodynamics of simvastatin in pure solvents and binary solvent mixtures

Solution thermodynamics of simvastatin in pure solvents and binary solvent mixtures

Diffusion and Controlled Release in Physically Crosslinked Poly (Vinyl Alcohol)/Iota-Carrageenan Hydrogel Blends

Prevention of urinary infection through the incorporation of silver–ricinoleic acid–polystyrene nanoparticles on the catheter surface

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