Measurement and Interpretation of Synovial Fluid Viscosities

Barnett, C. H.

doi:10.1136/ard.17.2.229

Cited by 27 publications

(13 citation statements)

References 11 publications

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“…Overcoming each of these steps requires energy input, and the temperature dependence of these inputs may thus stack up. After some critical temperature, the energy required for some or many of these steps might be greatly diminished, causing a steep change in the observed overall activation energy (e.g., fluidity of synovial liquid increases nonlinearly with temperature, so joint friction decreases with temperature, Barnett (); cell membrane fluidity also increases, facilitating cell shape change, Heimburg, ).…”

Section: Discussionmentioning

confidence: 99%

“…The order matches that of Table 1 stack up. After some critical temperature, the energy required for some or many of these steps might be greatly diminished, causing a steep change in the observed overall activation energy (e.g., fluidity of synovial liquid increases nonlinearly with temperature, so joint friction decreases with temperature, Barnett (1958); cell membrane fluidity also increases, facilitating cell shape change, Heimburg, 2007). An important prediction of this explanation in terms of additive activation energies is that the activation energy of a biological process should increase with the complexity of the process.…”

Section: Changes In Activation Energy and Its Potential Causesmentioning

confidence: 99%

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Crossing regimes of temperature dependence in animal movement

Gibert

Chelini

Rosenthal

et al. 2016

Global Change Biology

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A pressing challenge in ecology is to understand the effects of changing global temperatures on food web structure and dynamics. The stability of these complex ecological networks largely depends on how predator-prey interactions may respond to temperature changes. Because predators and prey rely on their velocities to catch food or avoid being eaten, understanding how temperatures may affect animal movement is central to this quest. Despite our efforts, we still lack a mechanistic understanding of how the effect of temperature on metabolic processes scales up to animal movement and beyond. Here, we merge a biomechanical approach, the Metabolic Theory of Ecology and empirical data to show that animal movement displays multiple regimes of temperature dependence. We also show that crossing these regimes has important consequences for population dynamics and stability, which depend on the parameters controlling predator-prey interactions. We argue that this dependence upon interaction parameters may help explain why experimental work on the temperature dependence of interaction strengths has so far yielded conflicting results. More importantly, these changes in the temperature dependence of animal movement can have consequences that go well beyond ecological interactions and affect, for example, animal communication, mating, sensory detection, and any behavioral modality dependent on the movement of limbs. Finally, by not taking into account the changes in temperature dependence reported here we might not be able to properly forecast the impact of global warming on ecological processes and propose appropriate mitigation action when needed.

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Section: Discussionmentioning

confidence: 99%

Section: Changes In Activation Energy and Its Potential Causesmentioning

confidence: 99%

Crossing regimes of temperature dependence in animal movement

Gibert

Chelini

Rosenthal

et al. 2016

Global Change Biology

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“…Samples were filtered through 5 A Millipore filters to remove threads or particles. To measure relative viscosity, an Ostwald viscometer (2-ml capacity) was used with a flow time for the buffer of 180 seconds in a constant temperature bath at 250 C + 0.10 C. Anomalous viscosity was determined by a modification of the method of Levine and Kling (14) and the results were plotted according to methods of Barnett (15).…”

mentioning

confidence: 99%

Isolation of Hyaluronateprotein From Human Synovial Fluid*

Sandson¹,

Hamerman²

1962

J. Clin. Invest.

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“…In particular, the decrease of the hyaluronic acid in the synovial fluid has been associated with arthritic disease because the lubricating properties of synovial fluid and its viscosity depend on the concentration of the hyaluronic acid [4][5][6][7][8]. Moreover, the relationship between changes in the viscosity of the synovial fluid and the joint affections is widely documented [4][5][6][7][8][9][10][11][12][13].…”

Section: Present Problematic and Hypothesismentioning

confidence: 99%

“…[4][5][6][7][8] It is widely documented the relationship between changes in viscosity of the synovial fluid and joint VII conditions [4][5][6][7][8][9][10][11][12][13]. Based on this relationship between hyaluronic acid and some arthritic diseases, the synovial fluid analysis can contribute fundamental information to diagnosis and treatments for joint diseases.…”

Section: Design and Evaluation Of A Biosensor Based On Quartz Crystalmentioning

confidence: 99%

Diseño y evaluación de un biosensor basado en resonadores de cristal de cuarzo (QCR) para caracterizar muestras biológicas relacionadas con enfermedades artríticas

Ahumada¹,

Armando²

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IVResumen de la tesis de Luis Armando Carvajal Ahumada, presentada como requisito parcial para la obtención del grado de DOCTOR en INGENIERÍA BIOMÉDICA. Madrid, 03 de Abril de 2017 DISEÑO Y EVALUACIÓN DE UN SENSOR BASADO EN RESONADORES DE CRISTAL DE CUARZO (QCR) PARA CARACTERIZAR MUESTRAS BIOLÓGICAS RELACIONADAS CON LA DIAGNOSIS DE ENFERMEDADES ARTRÍTICASResumen:Los resonadores de cristal de cuarzo son dispositivos ampliamente utilizados como biosensores debido a su alta sensibilidad ante fenómenos físico-químicos que ocurren en su superficie, a la reproducibilidad de las mediciones y por ser transductores fáciles de utilizar. Sauerbrey[1] fue el primero en demostrar que el resonador cristal de cuarzo puede ser utilizado como una microbalanza útil para caracterizar pequeñas deposiciones de masa en el electrodo del cristal. Sauerbrey demostró que, si se deposita una delgada capa de material rígido sobre el cristal de cuarzo, tanto el cristal como el material depositado vibrarán a la misma frecuencia y se generará un cambio en la frecuencia de resonancia inicial del cristal. Específicamente, la frecuencia de resonancia disminuye al aumentar la cantidad de masa depositada.El cristal de cuarzo también puede operar en medio fluidos. En este caso además del desplazamiento en frecuencia del cristal, se genera una pérdida significativa en el factor de calidad del resonador. Para fluidos Newtonianos (viscosidad constante), Kanazawa y Gordon[2] demostraron que el desplazamiento en frecuencia que sufre el resonador así como el cambio en el ancho de la curva de admitancia, depende de la densidad y la viscosidad del líquido. Este fenómeno permite utilizar los resonadores de cristal de cuarzo como pequeños viscosímetros siempre que se conozca la densidad del fluido a analizar.En el caso de deposición de fluidos viscoelásticos, la medición del cambio en la frecuencia de resonancia del cristal no es suficiente para obtener el valor de viscosidad del fluido. Por tanto, se requiere de la medición de una segunda variable (mitad del ancho de media banda -Γ) para obtener el valor correcto de la viscosidad del fluido depositado.[3] Para fluidos pseudoplásticos (viscosidad aparente dependiente de la velocidad de cizallamiento aplicada), se requiere de un modelo matemático que explique el comportamiento de la viscosidad del fluido a distintas velocidades de cizallamiento. En particular para el análisis de muestras con este comportamiento, se ha elegido el modelo Rouse ya que explica con suficiente detalle el comportamiento pseudoplástico y resulta simple de aplicar a las medidas experimentales.En este trabajo se propone el diseño de un biosensor basado en un resonador de cristal de cuarzo (QCR) para la caracterización de muestras biológicas que emulan el comportamiento del líquido sinovial.El líquido sinovial es una mezcla de plasma dializado y ácido hialurónico con comportamiento pseudoplástico. Su principal función es la de actuar como lubricante en las articulaciones V manteniendo al mínimo la fricción entre los huesos, especialment...

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Measurement and Interpretation of Synovial Fluid Viscosities

Cited by 27 publications

References 11 publications

Crossing regimes of temperature dependence in animal movement

Crossing regimes of temperature dependence in animal movement

Isolation of Hyaluronateprotein From Human Synovial Fluid*

Diseño y evaluación de un biosensor basado en resonadores de cristal de cuarzo (QCR) para caracterizar muestras biológicas relacionadas con enfermedades artríticas

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