“…Several publications have comprehensively reported how 2-D and 3-D simulation approaches using various CFD packages (e.g. Fluent and CFX) can be helpful to predict agglomeration behavior during spray drying [33,49,97], evaluate particle trajectories [11], design new drying chamber configurations and assess atomizer performance [11,[36][37][38] as well as to study gas distribution within drying chambers [11,28,33,34,45,50,53,68,93,101,111]. The accuracy of prediction by finerscale approaches mainly depends on the selection of mass-heat-momentum conservation equations, the accuracy of turbulence models, the appropriateness of numerical methods used for solving equations and the quality of grid generation and algorithm development [28,47,50].…”