Measurement in human blood of fibrinogen/fibrin fragments containing the Bβ 15–42 sequence

Kudryk, B.; Robinson, D.; Netré, C.; Hessel, B.; Blombäck, M.; Blombäck, B.

doi:10.1016/0049-3848(82)90111-6

Cited by 18 publications

(20 citation statements)

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“…The sample for FpA was collected in a special anticoagulant, and fibrinogen was extracted with ethanol before the sample was frozen, as has been previously described. 16 For the D-dimer sample, aprotinin (0.2 TIU/mL; Sigma Chemical Co, St Louis, Mo) was added to the anticoagulant. The samples were centrifuged (10 minutes, 1300g, 22°C) without delay, and the plasma was separated into polypropylene tubes to be frozen and stored at -20°C (D-dimer at -70°C).…”

Section: Blood Samplingmentioning

confidence: 99%

Severity of peripheral atherosclerosis is associated with fibrinogen and degradation of cross-linked fibrin.

Lassila

Peltonen

Lepäntalo

et al. 1993

Arterioscler Thromb

126

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Section: Blood Samplingmentioning

confidence: 99%

Severity of peripheral atherosclerosis is associated with fibrinogen and degradation of cross-linked fibrin.

Lassila

Peltonen

Lepäntalo

et al. 1993

Arterioscler Thromb

126

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“…Deteri oration of coagulative and fibrinolytic sys tems leading to disseminated intravascular coagulation did not occur [3,10,12].…”

Section: Discussionmentioning

confidence: 99%

Platelet Aggregability and Prostacyclin/Thromboxane A<sub>2</sub> Ratio after Endoscopic Injection Sclerotherapy with Different Sclerosants

Yamaga

Hashizume²,

Wada

et al. 1991

Eur Surg Res

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Platelet aggregability and coagulative and fibrinolytic systems were analyzed with regard to positive effects and for side effects of 5 % ethanolamine oleate (EO) versus 5 % sodium morrhuate (SM) used for endoscopic injection sclerotherapy (EIS). Twelve patients each were treated with each sclerosant. There was a temporary activation of coagulative and fibrinolytic systems within 1 h in both groups. Platelet aggregability was significantly suppressed to 78.6 ± 8.9% of that before EIS in the EO group, but was activated to 110.0 ± 10.5% in the SM group at 1 h after EIS. The ratio of concentrations of prostacyclin (PGI₂) to thromboxane A₂ (TXA₂) increased int he EO group and decreased in the SM group after EIS. The clinical effect in the SM group after the initial session was weaker than that in the EO group with regard to endoscopic findings at the second session. As change in platelet aggregability after EIS is apparently induced by alterations in the ratio of PGI₂/TXA₂, there would be related effects concerning the sclerosants.

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“…The coefficient of variation (CV) was 3.5%. FPA and Bp 15-42 were measured by radioimmunoassays: BYK Mallinckrodt for FPA [4,5], and Imco (Sweden) and Sorin Biomedica (Italy) for Bp 15-42 [2]. Our normal range for FPA was 0.6-4.6 ng/ml (CV 4.8%), while for Bp 15-42 it was 5.1-15.1 ng/ml (CV 4.3%).…”

Section: Methodsmentioning

confidence: 99%

“…In order to im prove detection even of minimal fibrinolysis activation, in addition to FPA and a 2-AP we measured fibrinopeptide Bp 15-42 (Bp 15-42), which is a sensitive direct indicator of plasmin activity in vivo [2], This is the first report on Bp 15-42 in liver cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

Fibrinopeptide A and Bβ 15–42 in Liver Cirrhosis

Marongiu

Mameli²,

Acca³

et al. 1988

Pathophysiol Haemos Thromb

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In order to detect even minimal fibrinolysis activation in liver cirrhosis, we measured fibrinopeptide Bβ 15–42 (Bβ 15–42), an indicator of plasmin activity in vivo and α₂-antiplasmin (α₂-AP) in a group of cirrhotic patients. The second goal of this study was to investigate whether an increased fibrinolytic activity is related to a chronic disseminated intravascular coagulation. For this purpose we concomitantly measured fibrinopeptide A (FPA), marker of thrombin activity in vivo. Results show significantly higher levels of Bβ 15–42 in cirrhotic patients than in control (p < 0.01). In patients with high FPA levels we found significantly higher values than in patients with normal FPA (p < 0.01). α₂-AP was lower in patients with high FPA levels than in patients with normal FPA (p < 0.05). A significant negative correlation was found between FPA and α₂-AP only in patients with high FPA (p < 0.05). There was no relationship between Bβ 15–42 and FPA nor between Bβ 15–42 and α₂-AP when all patients were considered. These findings confirm that in liver cirrhosis fibrinolysis activation may occur. The primary pathogenetic role of DIC may be important in this respect. However the lack of correlation between FPA and Bβ 15–42 suggests that other pathogenetic factors may be involved in determining fibrinolysis activation.

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Measurement in human blood of fibrinogen/fibrin fragments containing the Bβ 15–42 sequence

Cited by 18 publications

References 0 publications

Severity of peripheral atherosclerosis is associated with fibrinogen and degradation of cross-linked fibrin.

Severity of peripheral atherosclerosis is associated with fibrinogen and degradation of cross-linked fibrin.

Platelet Aggregability and Prostacyclin/Thromboxane A<sub>2</sub> Ratio after Endoscopic Injection Sclerotherapy with Different Sclerosants

Fibrinopeptide A and Bβ 15–42 in Liver Cirrhosis

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