1980
DOI: 10.1136/jcp.33.3.254
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Measurement in jejunal biopsies by computer-aided microscopy.

Abstract: A method of morphometric analysis of jejunal mucosa using computer-aided microscopy is described. It is based on the technique of interactive computer graphics with definition by the observer of areas and lengths for measurement, but it also includes automatic measurements based on grey-level segmentation. The analyses are performed rapidly and efficiently. The technique is applicable to the analysis of biopsy tissue from many sites.

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Cited by 42 publications
(18 citation statements)
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“…These sections were stained with haematoxylin and eosin, Giemsa, and Ziehl-Neelsen (ZN), and used for identification of parasites and acid-alcohol fast bacteria, and for morphometry. Morphometry was carried out with the Axio Home Graphics Workstation 28. Measurements were made of villous height (VH), crypt depth (CD), villus:crypt ratio (VC), and total mucosal thickness (TMT) in biopsy specimens in which at least four well orientated villi were visible.…”
Section: Methodsmentioning
confidence: 99%
“…These sections were stained with haematoxylin and eosin, Giemsa, and Ziehl-Neelsen (ZN), and used for identification of parasites and acid-alcohol fast bacteria, and for morphometry. Morphometry was carried out with the Axio Home Graphics Workstation 28. Measurements were made of villous height (VH), crypt depth (CD), villus:crypt ratio (VC), and total mucosal thickness (TMT) in biopsy specimens in which at least four well orientated villi were visible.…”
Section: Methodsmentioning
confidence: 99%
“…The techniques employed have varied from simple measurements using linear scales and grids'-9 to use of the Weibel template'0 to measure surface-to-volume ratio'1 and television image analysis. '2 13 There have been fewer reports on jejunal morphometry in children. Jos14 and other authors'5 16 used simple micrometer measurements, Risdon and Keeling17 the surface-to-volume ratio method of Dunnill and Whitehead," and Meinhard et al '8 computer analysis of projections traced on to computer cards.…”
mentioning
confidence: 99%
“…An increase in villus height in MOS-supplemented birds is a positive indicator of intestinal health and increased absorptive area (Ruttanavut and Yamauchi, 2010;Tufarelli et al, 2010), whereas a reduction in the villus height to crypt depth ratio is a sensitive indicator of villus atrophy (Slavin et al, 1980), a condition that can lead to malabsorption of nutrients. To further support these histological findings, litter moisture was scored in experiment two.…”
Section: Resultsmentioning
confidence: 99%