Measurement of Acetaldehyde: What Levels Occur Naturally and in Response to Alcohol?

Relationship between acetaldehyde concentration in mouth air and tongue coating volume

“…The values were higher than in a previous study, which reported that the physiological concentration of acetaldehyde in human breath was 0.4-1.6 ppb using gas chromatography 5 . The difference may be due to experimental conditions.…”

“…Although one study has reported data on physiological concentrations of acetaldehyde in human breath (0.4-1.6 ppb) 5 , the relationship between its concentration and oral condition, which may affect local production of acetaldehyde, is uncertain. In this study, acetaldehyde concentration in mouth air was significantly related to tongue coating status.…”

“…Only one study has reported data on physiological concentrations of acetaldehyde in human breath (0.4-1.6 ppb) in a small number of subjects (n=20) 5 . However, the relationship between physiological concentrations of acetaldehyde in human breath and oral condition is uncertain.…”

Determination of aldehydes in exhaled breath of patients with lung cancer by means of on-fiber-derivatisation SPME–GC/MS

“…Formaldehyde and acetaldehyde were excluded because of their presence in the indoor and outdoor environments [45,46] and as combustion products of tobacco smoke [47,48], particularly considering that many patients with lung cancer are ex-or current smokers. Furthermore, breath acetaldehyde levels are closely related to the metabolism of ethanol [49][50][51].…”

BK Channels – Focus on Polyamines, Ethanol/Acetaldehyde and Hydrogen Sulfide (H2S)

“…The metabolism and regulation of ACA particularly in blood or liver occurs via activities of alcohol dehydrogenase (ADH), cyctochrome P450, catalase and aldehyde dehydrogenase. The blood concentrations of ACA after ethanol consumption was found extremely low (<0.5 µM) (Eriksson & Fukunaga 1993;Eriksson 2007) and together with the activity of the blood-brain barrier it appeared unlikely to penetrate the brain in any pharmacological relevant amounts. However, ACA can be produced within the brain from ethanol through catalase and/or cytochrome P-4502E1 which makes it more likely that biologically significant concentrations at least in some brain areas can be achieved (Karahanian et al, 2011;Correa et al, 2011;Deng & Deitrich 2008;Quertemont et al 2005).…”