Measurement of Albumin and Other Urinary Proteins in Low Concentration in Diabetes Mellitus: Techniques and Clinical Significance

Rowe, David J.; Gatling, W.

doi:10.1007/978-1-4757-6746-9_8

Cited by 2 publications

(3 citation statements)

References 37 publications

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“…Urinary albumin excretion is elevated above normal before the onset of proteinuria, but the amount excreted at this time cannot be accurately detected by the routine measurement of total proteinuria at routine urinalysis, and requires the precise determination of urinary albumin by immunoassay (20). This increase in urinary albumin excretion, still below the levels of clinical proteinuria, has been defined microalbuminuria and has long been shown to precede and predict clinical proteinuria and end-stage renal failure both in IDDM (17) and in NIDDM (18).…”

Section: Definition Of Microalbuminuria and Screening Proceduresmentioning

confidence: 99%

Microalbuminuria in Diabetes

Mangili¹

1998

CCLM

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Microalbuminuria is still the only early abnormality of the diabetic kidney that has an established prognostic value. Microalbuminuria evolves into clinical nephropathy and renal failure in a majority of cases of insulin-dependent diabetic patients, and is defined by the detection of urinary albumin excretion rates of 20-200 microg/min in timed urine collections. The occurrence of microalbuminuria at rates of 5-27 % of non-proteinuric patients and cost-benefit considerations justify the screening for microalbuminuria in diabetic outpatient clinics. Both near-normalisation of glycaemic control and treatment with ACE-inhibitors are indicated in patients with insulin-dependent diabetes to correct the progression of micro- to macroalbuminuria. Other therapeutic perspectives are being considered, but the current notion that the available therapies may not arrest the course of nephropathy at this stage suggests that earlier interventions may be required. Prevention of microalbuminuria and overt nephropathy may require a primary approach to the subset of patients with a genetic predisposition to this complication, and several studies (candidate gene or genomic scan with microsatellite probes) now address the chromosomal loci and the nature of the genes that may be involved.

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Section: Definition Of Microalbuminuria and Screening Proceduresmentioning

confidence: 99%

Microalbuminuria in Diabetes

Mangili¹

1998

CCLM

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“…Different methods for measuring urinary albumin can be used: immunoturbidimetry, immunonephelometry, radio-or enzyme-immunoassays. Although immunoturbidimetry lacks the sensitivity to detect very low albumin concentrations and immunoassays have the highest sensitivity, all methods are considered equivalent when quality control is maintained [4].…”

Section: How To Screen and Measure Urinary Albuminmentioning

confidence: 99%

“…Improvement was especially remarkable for renal transplantation: in 1992, first-year survival of diabetic recipients of a first cadaveric graft equalled that of non-diabetic controls [2]. Interestingly, the survival of diabetics on dialysis was similar whether the ESRD was due to diabetic nephropathy or to another primary nephropathy, suggesting that diabetes is the main determinant of survival whether or not it causes renal failure [4].…”

Section: Survival On Rrtmentioning

confidence: 99%

How to diagnose and how to interpret microalbuminuria in the diabetic patient

Czekalski¹

1996

Nephrology Dialysis Transplantation

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Measurement of Albumin and Other Urinary Proteins in Low Concentration in Diabetes Mellitus: Techniques and Clinical Significance

Cited by 2 publications

References 37 publications

Microalbuminuria in Diabetes

Microalbuminuria in Diabetes

How to diagnose and how to interpret microalbuminuria in the diabetic patient

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