Measurement of Contents in Organs of Selenium- or Vitamin E-Deficient Rat Using Instrumental Neutron Activation Analysis

Matsumoto, Ken‐ichiro; Yamazaki, Megumi; Satoh, Kazue; Ushio, Fusao; Endo, Kazutoyo

doi:10.1248/yakushi.122.283

Cited by 10 publications

(22 citation statements)

References 12 publications

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“…75 Se, 59 Fe, and 65 Zn were analyzed by the photopeaks at 264.6, 1098.6, and 1115.4 keV respectively. 1,2) Copper in the Diet ---The chemical reagents, 68% HNO 3 , HClO 4 , used for sample digestion were TAMAPURE-AA-10, (ultra-pure grade reagents for chemical analysis). Working curve was made using standard solutions for atomic absorption (Wako Pure Chemicals, Tokyo).…”

Section: Methodsmentioning

confidence: 99%

“…1,2) Se, which has important roles of the redox regulation system in our body, is an essential trace element. Se-deficiency causes a malfunction of glutathione peroxidase (GSH-Px).…”

Section: Introductionmentioning

confidence: 99%

“…2) It was considered that variation of Fe and Zn in the liver of SeD rats can be caused as a results of sensitive response to the oxidative stress. Contents of Fe and Zn in the tissues may be related to each other in the in vivo redox system.…”

Section: Introductionmentioning

confidence: 99%

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Feeding Period of Selenium-Deficient Diet and Response of Redox Relating Minerals

Matsumoto

Ariyoshi

Terada

et al. 2006

JOURNAL OF HEALTH SCIENCE

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Section: Methodsmentioning

confidence: 99%

“…1,2) Se, which has important roles of the redox regulation system in our body, is an essential trace element. Se-deficiency causes a malfunction of glutathione peroxidase (GSH-Px).…”

Section: Introductionmentioning

confidence: 99%

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Feeding Period of Selenium-Deficient Diet and Response of Redox Relating Minerals

Matsumoto

Ariyoshi

Terada

et al. 2006

JOURNAL OF HEALTH SCIENCE

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“…The Se content of the SeD was reported in our previous paper as 0.017 mg/kg by instrumental neutron activation analysis (INAA). 6) Deionized water prepared by Milli-Q system was used for all experiments and used for drinking water for rats. Other materials were in analytical grade.…”

Section: Methodsmentioning

confidence: 99%

“…Hence, the intracellularly important molecular functions of lipids, sugars, proteins, and/or nucleic acids could be oxidatively damaged, which will finally result in some disorders. Selenium-deficient (SeD) rat model, [3][4][5][6][7] therefore, have been used to investigate the oxidative stress caused by H 2 O 2 .…”

mentioning

confidence: 99%

Correlation between Keton Body Level in Selenium-Deficient Rats and Oxidative Damages

Matsumoto

Takuwa

Terashi

et al. 2005

Biological & Pharmaceutical Bulletin

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The age dependence of ketone body levels (KBLs) and oxidative damages in selenium-deficient (SeD) and normal rats were compared. The feeding SeD diets gave ketogenesis and higher KBLs especially in younger rats. However, KBLs in SeD rats seemed to decrease with their age. Feeding 0.1 mg/kg Se in water with SeD diet did not affect the KBLs in young (8 week old) rats, whereas the addition of Se reduced the KBLs in older (20 week old) rats. Blood KBLs showed some correlations with tissue damage. TBARSs showed no correlations with the tissue damages and KBLs when the values were compared between the same age, while better correlation was obtained between urinary KBLs of 6-20 week old normal rats and the liver TBARSs of 4-16 week old normal rats. The oxidative injury might induce liver damage with some delay. SeD rat kidney TBARS levels normalized by protein had some correlations with BUN and blood KBL. Kidney may be sensitive to the oxidative stresses and/or injuries. Tissue damages of SeD rats decreased with age. In contrast, oxidative injuries might be gradually accumulated in normal rat tissue. Oxidative stress can be visible by gradual accumulation of small damages during the aging, while large stress in young rats can be buffered and masked. The aging based accumulation of oxidative injuries might also be correlated with KBLs, while it might not give notable tissue damages.

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Biliary excretion of essential trace elements in rats under oxidative stress caused by selenium deficiency

et al. 2011

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The excretion of essential trace elements, namely, Se, Sr, As, Mn, Co, V, Fe, and Zn into the bile of Se-deficient (SeD) Wistar male rats was studied using the multitracer (MT) technique, and instrumental neutron activation analysis (INAA). Normal and Se-control (SeC) rat groups were used as reference groups to compare the effects of Se levels on the behaviors of the essential trace elements. The excretion (% dose) of Se, Sr, As, Mn, Co, and V increased with Se levels in the liver. The biliary excretion of Mn and As dramatically enhanced for SeC rats compared with SeD rats, while that of V accelerated a little for SeC rats. The radioactivity levels of (59)Fe and (65)Zn in the MT tracer solution were insufficient to measure their excretion into bile. The role of glutathione and bilirubin for biliary excretion of the metals was discussed in relation to Se levels in rat liver.

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Measurement of Contents in Organs of Selenium- or Vitamin E-Deficient Rat Using Instrumental Neutron Activation Analysis

Cited by 10 publications

References 12 publications

Feeding Period of Selenium-Deficient Diet and Response of Redox Relating Minerals

Feeding Period of Selenium-Deficient Diet and Response of Redox Relating Minerals

Correlation between Keton Body Level in Selenium-Deficient Rats and Oxidative Damages

Biliary excretion of essential trace elements in rats under oxidative stress caused by selenium deficiency

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