The measurement of Hubble constant (H 0 ) is clearly a very important task in astrophysics and cosmology. Based on the principle of minimization of the information loss, we propose a robust most frequent value (MFV) procedure to determine H 0 , regardless of the Gaussian or non-Gaussian distributions. The updated data set of H 0 contains the 591 measurements including the extensive compilations of Huchra and other researchers. The calculated result of the MFV is H 0 =67.498 km s −1 Mpc −1 , which is very close to the average value of recent Planck H 0 value (67.81±0.92 km s −1 Mpc −1 and 66.93±0.62 km s −1 Mpc −1 ) and Dark Energy Survey Year 1 Results. Furthermore, we apply the bootstrap method to estimate the uncertainty of the MFV of H 0 under different conditions, and find that the 95% confidence interval for the MFV of H 0 measurements is [66.319, 68.690] associated with statistical bootstrap errors, while a systematically larger estimate is H 67.498 0 3.278 7.970 = -+ (systematic uncertainty). Especially, the non-Normality of error distribution is again verified via the empirical distribution function test including Shapiro-Wilk test and Anderson-Darling test. These results illustrate that the MFV algorithm has many advantages in the analysis of such statistical problems, no matter what the distributions of the original measurements are.