Measurement of malondialdehyde as oxidative stress biomarker in goat plasma by HPLC-DAD

Yonny, Melisa E.; García, Elisa Mariana; López, Alfonso; Arroquy, José Ignacio; Nazareno, Mónica A.

doi:10.1016/j.microc.2016.07.010

Cited by 48 publications

(29 citation statements)

References 25 publications

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“…MDA, formed endogenously by lipid peroxidation, is commonly used as an oxidative stress marker in body cells and tissues (Syslova et al ., ; Yonny et al ., ). MDA has also long been used as oxidation marker for evaluating oxidation status of vegetable oils.…”

Section: Resultsmentioning

confidence: 97%

“…Kinetic changes of AV, POV, p-AV, MDA and fatty acid composition in vegetable oils during accelerated oxidation MDA, formed endogenously by lipid peroxidation, is commonly used as an oxidative stress marker in body cells and tissues (Syslova et al, 2009;Yonny et al, 2016). MDA has also long been used as oxidation marker for evaluating oxidation status of vegetable oils.…”

Section: Resultsmentioning

confidence: 99%

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Amounts of malondialdehyde do not accurately represent the real oxidative level of all vegetable oils: a kinetic study of malondialdehyde formation

Liu

2018

Int J of Food Sci Tech

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Summary Malondialdehyde (MDA), a widely used oxidation indicator for both lipid and edible oil, has been suggested to be genotoxic and cytotoxic, thus attracting increasing attentions about its formation and exposure assessment. In this study, kinetics of MDA formation in vegetable oils and model oils were investigated by high‐performance liquid chromatography. Results showed MDA contents firstly increased rapidly then kept to a plateau over time in both reaction systems at 100, 140 and 180 °C, significant temperature‐dependent of MDA formation was observed. The rate constant and activation energy (Ea) were calculated from the fitted pseudo‐first‐order model and Arrhenius equation. Ea of MDA‐formation was much lower in linseed oil, corn oil and rapeseed oil, indicating the higher degree of unsaturation resulted in the greater susceptibility to MDA formation. Besides, MDA content was inappropriate to assess the oxidation of palm oil and camellia oil possessing high level of saturated and/or monounsaturated fatty acid.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Amounts of malondialdehyde do not accurately represent the real oxidative level of all vegetable oils: a kinetic study of malondialdehyde formation

Liu

2018

Int J of Food Sci Tech

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“…12 Malondialdehyde (MDA) is an advanced oxidation product and a recognized oxidative stress biomarker. 13 Therefore, the objective of measuring MDA is that it serves as an indirect biomarker of ROS activity. 14 Collectively, endothelial injury, sRAGE, AGE, and ROS appear predictive of restenosis.…”

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confidence: 99%

Advanced Glycation End Products:Receptors for Advanced Glycation End Products Axis in Coronary Stent Restenosis: A Prospective Study

et al. 2018

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This study was aimed to correlate the pre- and 6-month postpercutaneous coronary intervention (PCI) serum concentrations of advanced glycation end products (AGE), soluble receptors for advanced glycation end products (sRAGE), AGE/sRAGE ratio, and serum malondialdehyde (MDA) levels with in-stent restenosis (ISR) among patients receiving either a drug-eluting stent (DES) or a bare-metal stent (BMS).In-stent restenosis remains as an adverse outcome following PCI. Sixty consecutive nondiabetic, Caucasian male patients, diagnosed with a non-ST-elevation myocardial infarction who received either a DES or BMS via PCI, were enrolled. Baseline levels of serum AGE, sRAGE, AGE/sRAGE ratios, MDA, and angiographic parameters were determined at stenting and at 6 months. Patients with and without ISR at 6 months were compared on both baseline and 6-month biomarker levels and within stent types.The pre-PCI serum AGE levels and AGE/sRAGE ratios were higher in ISR patients compared with non-ISR patients, while the pre-PCI and post-PCI serum sRAGE levels were lower in ISR patients compared with non-ISR patients. The pre and post-PCI levels of MDA were also higher in ISR patients. Comparing stent types, relative levels of MDA between those with and without ISR at the respective time points were similar, although changes between time points appeared type specific.Post-PCI ISR correlates with low serum values of sRAGE and high serum values of AGE, MDA, and AGE/sRAGE ratio which are present at stenting. The associations of baseline AGE, sRAGE, AGE/sRAGE, and MDA levels with ISR appear consistent between stent types.

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“…Also, the level of MDA and advanced oxidative protein Product (AOPP), increased significantly in rats administered NaF compared with rats treated with quercetin; strongly suggesting an aggravation of free radical production in excess of the amounts that can be processed by the endogenous antioxidant system, leading to increased lipid peroxidation and production of MDA as an advanced oxidation product . Increased AOPP levels are often associated with increased carotid intima media thickness and may aid the development of arteriosclerosis .…”

Section: Discussionmentioning

confidence: 99%

Quercetin attenuates hypertension induced by sodium fluoride via reduction in oxidative stress and modulation of HSP 70/ERK/PPARγ signaling pathways

et al. 2018

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Hypertension is one of the silent killers in the world with high mortality and morbidity. The exposure of humans and animals to fluoride and/or fluoride containing compounds is almost inevitable. This study investigated the modulatory effects of quercetin on sodium fluoride (NaF)-induced hypertension and cardiovascular complications. Forty male rats were randomly separated into four groups (n =10). Group A animals served as the control, rats in Group B were exposed to 300 ppm of NaF, Groups C and D animals were exposed to 300 ppm of NaF along with quercetin orally at 50 mg/kg and 100 mg/kg orally by gavage, while NaF was administered in drinking water, respectively, for a week. Administration of NaF caused severe hypertension as indicated with significant increases in the systolic, diastolic, and mean arterial blood pressure, togetherAbbreviations: ANOVA, one-way analysis of variance; AOPP, advanced oxidation protein product; AP-1, activator protein-1; AST, aspartate aminotransfer-

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Measurement of malondialdehyde as oxidative stress biomarker in goat plasma by HPLC-DAD

Cited by 48 publications

References 25 publications

Amounts of malondialdehyde do not accurately represent the real oxidative level of all vegetable oils: a kinetic study of malondialdehyde formation

Amounts of malondialdehyde do not accurately represent the real oxidative level of all vegetable oils: a kinetic study of malondialdehyde formation

Advanced Glycation End Products:Receptors for Advanced Glycation End Products Axis in Coronary Stent Restenosis: A Prospective Study

Quercetin attenuates hypertension induced by sodium fluoride via reduction in oxidative stress and modulation of HSP 70/ERK/PPARγ signaling pathways

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