Measurement of Malondialdehyde, Glutathione, and Glutathione Peroxidase in SLE Patients

Gheita, Tamer A.; Kenawy, Sanaa A.

doi:10.1007/978-1-4939-0326-9_14

Cited by 27 publications

(15 citation statements)

References 18 publications

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“…Anti-oxidant scavengers such as GSH are commonly used for the evaluation of anti-oxidant activities ( 32 ). In addition, SOD has been implicated in inflammatory diseases and oxidative stress ( 33 , 34 ).…”

Section: Discussionmentioning

confidence: 99%

Aï¿½aï¿½ (Euterpe oleracea Mart.) attenuates alcohol‑induced liver injury in rats by alleviating oxidative stress and inflammatory response

et al. 2017

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The present study aimed to investigate the therapeutic effects of Euterpe oleracea Mart. (EO) on alcoholic liver diseases (ALD). A total of 30 Wistar rats were randomly divided into three groups (10 rats per group), including alcohol group (alcohol intake), EO group (alcohol + EO puree intake) and control group (distilled water intake). The activity of superoxide dismutase (SOD) and alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and the levels of cholesterol (CHO), triglyceride (TG), malondialdehyde (MDA) and glutathione (GSH) in the serum as well as the liver tissue levels of interleukin 8 (IL-8), tumor necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β) were measured. Histopathological changes in liver tissues were observed by hematoxylin and eosin staining. Reverse-transcription quantitative PCR analysis was performed for detecting the expression of nuclear factor (NF)-κB and CD68. The results indicated that EO intake significantly decreased ALT, AST, ALP, TG and CHO as well as the hepatic index in alcohol-treated rats. In addition, EO treatment relieved alcohol-induced oxidative stress by decreasing the levels of MDA and TG, and increasing the activity of SOD and GSH levels. In addition, the expression of TNF-α, TGF-β, IL-8, NF-κB and CD-68 in the liver were decreased by EO treatment. Furthermore, EO intake alleviated the histopathological liver damage, including severe steatosis and abundant infiltrated inflammatory cells. In conclusion, EO alleviated alcohol-induced liver injury in rats by alleviating oxidative stress and inflammatory response.

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Section: Discussionmentioning

confidence: 99%

Aï¿½aï¿½ (Euterpe oleracea Mart.) attenuates alcohol‑induced liver injury in rats by alleviating oxidative stress and inflammatory response

et al. 2017

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“…Malondialdehyde, a biomarker of oxidative damage, was analyzed according to a previously reported method. 49 …”

Section: Methodsmentioning

confidence: 99%

Decreased expression of the APOA1–APOC3–APOA4 gene cluster is associated with risk of Alzheimer’s disease

Lin¹,

Cao²,

Gao³

2015

DDDT

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BackgroundApolipoprotein is genetically associated with the risk of Alzheimer’s disease (AD). The APOA1, APOC3, and APOA4 genes are closely linked and located on human chromosome 11. Therefore, this gene cluster may be related to the risk of AD.Patients and methodsA total of 147 AD patients and 160 healthy controls were randomly recruited from June 2013 to August 2014. APOA1, APOC3, and APOA4 levels were measured using real-time quantitative reverse-transcriptase polymerase chain reaction and enzyme-linked immunosorbent assay.ResultsAPOA1, APOC3 and APOA4 levels were significantly lower in AD patients than controls (P<0.01). APOA1, APOC3, and APOA4 levels were negatively related with the severities of AD determined by Clinical Dementia Rating scores (P<0.01). APOA1, APOC3, and APOA4 levels showed a negative relation with Montgomery–Åsberg Depression Rating Scale scores and a positive relation with RAND 36-item health-survey scores (P<0.01). There was a decreased trend for levels of APOA1, APOC3, and APOA4 in AD patients.ConclusionLow levels of APOA1, APOC3, and APOA4 are associated with risk of AD. APOA1, APOC3, and APOA4 should be developed as combined drugs for the therapy of AD.

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“…The blood samples were used for the measurement of TG, TC, HDL-c, and LDL-c levels, according to the commercial instructions for the biochemical analyzer (Beijing Jinji Aomeng Co., Ltd., Beijing, China). Malondialdehyde (MDA), one kind of the biomarkers of oxidative damage, was measured according to a previous report [ 46 ].…”

Section: Methodsmentioning

confidence: 99%

Dietary Blueberry and Bifidobacteria Attenuate Nonalcoholic Fatty Liver Disease in Rats by Affecting SIRT1-Mediated Signaling Pathway

Ren¹,

Huang²,

Cheng³

2014

Oxidative Medicine and Cellular Longevity

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NAFLD model rats were established and divided into NAFLD model (MG group), SIRT1 RNAi (SI group), blueberry juice (BJ group), blueberry juice + bifidobacteria (BJB group), blueberry juice + SIRT1 RNAi (BJSI group), and blueberry juice + bifidobacteria + SIRT1 RNAi groups (BJBSI group). A group with normal rats was a control group (CG). BJB group ameliorated NAFLD, which was better than BJ group (P < 0.05). The lipid accumulation was lower in CG, BJ, and BJB groups than that in MG, SI, BJSI, and BJBSI groups (P < 0.05). The levels of SIRT1 and PPAR-α were higher in CG, BJ, and BJB groups than those in MG, SI, BJSI, and BJBSI groups (P < 0.05). The levels of SREBP-1c were lower in CG, BJ, and BJB groups than those in MG, SI, BJSI, and BJBSI groups (P < 0.05). The biochemical indexes SOD, GSH, and HDL-c were improved from CG to BJB group (P < 0.05). Inversely, the levels of AST and ALT, TG, TC, LDL-c, and MDA were decreased from CG to BJB group (P < 0.05). These changes enhance antioxidative capability and biochemical index of rats. Blueberry juice and bifidobacteria improve NAFLD by activating SIRTI-mediating signaling pathway.

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Measurement of Malondialdehyde, Glutathione, and Glutathione Peroxidase in SLE Patients

Cited by 27 publications

References 18 publications

Aï¿½aï¿½ (Euterpe oleracea Mart.) attenuates alcohol‑induced liver injury in rats by alleviating oxidative stress and inflammatory response

Aï¿½aï¿½ (Euterpe oleracea Mart.) attenuates alcohol‑induced liver injury in rats by alleviating oxidative stress and inflammatory response

Decreased expression of the APOA1–APOC3–APOA4 gene cluster is associated with risk of Alzheimer’s disease

Dietary Blueberry and Bifidobacteria Attenuate Nonalcoholic Fatty Liver Disease in Rats by Affecting SIRT1-Mediated Signaling Pathway

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Measurement of Malondialdehyde, Glutathione, and Glutathione Peroxidase in SLE Patients

Cited by 27 publications

References 18 publications

Aï¿½aï¿½ (Euterpe oleracea Mart.) attenuates alcohol‑induced liver injury in rats by alleviating oxidative stress and inflammatory response

Aï¿½aï¿½ (Euterpe oleracea Mart.) attenuates alcohol‑induced liver injury in rats by alleviating oxidative stress and inflammatory response

Decreased expression of the APOA1&ndash;APOC3&ndash;APOA4 gene cluster is associated with risk of Alzheimer&rsquo;s disease

Dietary Blueberry and Bifidobacteria Attenuate Nonalcoholic Fatty Liver Disease in Rats by Affecting SIRT1-Mediated Signaling Pathway

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Decreased expression of the APOA1–APOC3–APOA4 gene cluster is associated with risk of Alzheimer’s disease