Measurement of optical distances by optical spectrum modulation

Fercher, Adolf Friedrich; Drexler, Wolfgang; Hitzenberger, Christoph K.; Kamp, G.

doi:10.1117/12.167429

Cited by 6 publications

(6 citation statements)

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“…Earlier reports of OCT used devices that operated in the time domain rather than the frequency domain, limiting system sensitivity and resulting in reduced penetration and contrast in the images. In this study we used a Fourier domain OCT device and have demonstrated the improved diagnostic accuracy for different types of NMSC.…”

Section: Discussionmentioning

confidence: 99%

The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study

et al. 2015

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has received speaker's honoraria from Almirall Hermal, Biofrontera, Galderma, Meda Pharma and JanssenCilag. C.B. has received speaker's and advisory board member's honoraria from, and has been involved in clinical trials sponsored by Almirall SummaryBackground The diagnostic criteria for basal cell carcinoma (BCC) using optical coherence tomography (OCT) have been described previously, but the clinical value of these findings remains unknown. Objectives To investigate the diagnostic value of OCT for BCC in a typical clinical setting. The primary efficacy end point was a diagnosis of BCC for each lesion. Secondary end points were the diagnosis of other possible conditions. Methods This was an observational, prospective, multicentre study in which consecutive patients with nonpigmented pink lesions suspicious for BCC underwent clinical assessment, dermoscopy and OCT, with the diagnosis recorded at each stage. Once all diagnoses had been recorded, the histological results were disclosed. In total 164 patients with 256 lesions were recruited. Histology was missing for 21 lesions, leaving 235 lesions in 155 patients for analysis. Results Sixty per cent of lesions (141 of 235) were identified as BCC by histology. A slight increase of sensitivity was noted following OCT, which did not reach statistical significance. The specificity increased significantly from 28Á6% by clinical assessment to 54Á3% using dermoscopy and to 75Á3% with the addition of OCT (P < 0Á001). The positive predictive value for the diagnosis of BCC using OCT was 85Á2% [95% confidence interval (CI) 78Á6-90Á4], and the negative predictive value was 92Á1% (95% CI 83Á6-97Á0). The accuracy of diagnosis for all lesions increased from 65Á8% with clinical evaluation to 76Á2% following additional dermoscopy and to 87Á4% with the addition of OCT. Conclusions OCT significantly improved the diagnostic specificity for BCC compared with clinical assessment and dermoscopy alone.

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Section: Discussionmentioning

confidence: 99%

The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study

et al. 2015

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“…Because the entire spectrum of the interference fringe intensity is acquired simultaneously with detector array, image acquisition time is reduced to T = NxΔtp using spectral ODT. An ODT image of 100 lateral pixels with velocity resolution of 100 μm/s can be acquired in a second [21] , [22] , [23] , [24] , [25] , [26] .…”

Section: Resultsmentioning

confidence: 99%

Noninvasive imaging analysis of biological tissue associated with laser thermal injury

Chang

Hsiao

et al. 2017

Biomedical Journal

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BackgroundThe purpose of our study is to use a noninvasive tomographic imaging technique with high spatial resolution to characterize and monitor biological tissue responses associated with laser thermal injury.MethodsOptical doppler tomography (ODT) combines laser doppler flowmetry (LDF) with optical coherence tomography (OCT) to obtain high resolution tomographic velocity and structural images of static and moving constituents in highly scattering biological tissues. A SurgiLase XJ150 carbon dioxide (CO2) laser using a continuous mode of 3 watts (W) was used to create first, second or third degree burns on anesthetized Sprague–Dawley rats. Additional parameters for laser thermal injury were assessed as well.ResultsThe rationale for using ODT in the evaluation of laser thermal injury offers a means of constructing a high resolution tomographic image of the structure and perfusion of laser damaged skin. In the velocity images, the blood flow is coded at 1300 μm/s and 0 velocity, 1000 μm/s and 0 velocity, 700 μm/s and 0 velocity adjacent to the first, second, and third degree injuries, respectively.ConclusionODT produces exceptional spatial resolution while having a non-invasive way of measurement, therefore, ODT is an accurate measuring method for high-resolution fluid flow velocity and structural images for biological tissue with laser thermal injury.

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“…11 The limited sensitivity of these devices stifled application in dermatology, but since 2015, there has been great interest in angiographic OCT based on so-called speckle-variance techniques pioneered by Mariampillai et al 12 Speckle variance and its close cousins decorrelation mapping 13 and OMAG 14 work on the principle of detecting rapid changes in OCT signal intensity that are produced by the effects of blood flow producing changes to the OCT interferometric signal; by mapping the image pixels where these rapid changes are detected, blood vessels in the upper dermis can be readily imaged and are best visualized in the en-face imaging plane (see Figs. [2][3][4][5].…”

Section: Advances In Optical Coherence Tomography Modalitiesmentioning

confidence: 99%

Advances in optical coherence tomography in dermatology—a review

2018

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Optical coherence tomography (OCT) was introduced as an imaging system, but like ultrasonography, other measures, such as blood perfusion and polarization of light, have enabled the technology to approach clinical utility. This review aims at providing an overview of the advances in clinical research based on the improving technical aspects. OCT provides cross-sectional and en face images down to skin depths of 0.4 to 2.00 mm with optical resolution of 3 to 15 μm. Dynamic optical coherence tomography (D-OCT) enables the visualization of cutaneous microvasculature via detection of rapid changes in the interferometric signal of blood flow. Nonmelanoma skin cancer (NMSC) is the most comprehensively investigated topic, resulting in improved descriptions of morphological features and diagnostic criteria. A refined scoring system for diagnosing NMSC, taking findings from conventional and D-OCT into account, is warranted. OCT diagnosis of melanoma is hampered by the resolution and the optical properties of melanin. D-OCT may be of value in diseases characterized with dynamic changes in the vasculature of the skin and the addition of functional measures is strongly encouraged. In conclusion, OCT in dermatology is still an emerging technology that has great potential for improving further in the future.

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Measurement of optical distances by optical spectrum modulation

Cited by 6 publications

References 0 publications

The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study

The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study

Noninvasive imaging analysis of biological tissue associated with laser thermal injury

Advances in optical coherence tomography in dermatology—a review

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