Measurement of Oxygen Tension in Human Perilymph

Fisch, Ugo; Murata, Kiyotaka; Hossli, G

doi:10.3109/00016487609119963

Cited by 58 publications

(17 citation statements)

References 2 publications

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“…The majority of sudden deafness mechanisms have been based on 2 common theories: inflammatory reaction and circulatory disturbance [1]. Concerning the circulatory theory of sudden deafness, Fisch et al [8] emphasized vascular compromise to the inner ear. In 16 cases of sudden deafness, Ciuffetti et al [9] likewise reported disturbances in microcirculatory blood flow as measured by blood filterability.…”

Section: Discussionmentioning

confidence: 99%

Sudden Deafness and Right-to-Left Shunts

et al. 2008

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Purpose: One of the etiologies for idiopathic sudden deafness is considered to be ischemia of the inner ear. Cryptogenic stroke is caused by a right-to-left shunt (RLS). The present study investigated whether RLS is associated with the occurrence of sudden deafness. Methods: Contrast saline transcranial Doppler ultrasonography was performed to detect RLS. Subjects comprised 23 consecutive sudden deafness patients and 46 age- and gender-matched controls. Clinical characteristics, including vascular risk factors, were compared between sudden deafness and control groups. Results: RLS was more frequent in the sudden deafness group than in controls (48 vs. 17%, p = 0.011). No significant differences in other clinical characteristics were seen between groups. Conclusion: RLS may be a potential cause of sudden deafness.

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Section: Discussionmentioning

confidence: 99%

Sudden Deafness and Right-to-Left Shunts

et al. 2008

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“…Though most investigators report improvement in up to 50% of patients [5] , an actual cure of tinnitus is rare and does not exceed the rates achieved by other treatment options or by placebo [8,16,19,20] .…”

Section: Discussionmentioning

confidence: 99%

“…It can originate from different locations along the auditory path, including cochlear lesions, disease of the auditory nerve, central auditory damage or psychological factors [18] . It has been shown that common pharmacological treatment does not yield better results than placebo therapy [8,16,19,20] . In spite of intensive research, the pathophysiology of tinnitus is still unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Therapeutic strategies involve intravenous hemorheological medication, tinnitus retraining therapy, masking devices, low-power laser, Gingko biloba, acupuncture, biofeedback or placebo treatment [3,[5][6][7][8] . The results of therapeutic modalities backed by sound pathophysiological considerations are hardly better than those of treatments lacking a scientific rationale.…”

Section: Introductionmentioning

confidence: 99%

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Hyperbaric Oxygen in Tinnitus: Influence of Psychological Factors on Treatment Results?

Porubsky

Stiegler²,

Matzi

et al. 2006

ORL

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Introduction: The standard treatment of subjective tinnitus hardly reaches the level of placebo controls. Though the effectiveness of hyperbaric oxygenation (HBO) for subjective tinnitus has never been objectified, it is still advocated by some institutions. We analyzed the effectiveness of hyperbaric oxygen treatment in the context of accompanying factors. Patients and Methods: We randomized 360 patients suffering from tinnitus into 2 HBO treatment protocols (group A: 2.2 bar for 60 min bottom time and group B: 2.5 bar for 60 min bottom time once a day for 15 days). All patients were asked to fill in a questionnaire (social and medical history, tinnitus characteristics, pre-HBO duration of tinnitus, prior therapy, pretreatment expectation, accompanying symptoms). A subjective assessment of the therapeutic effect was obtained. Results: Twelve patients (3.3%) experienced complete remission of tinnitus, in 122 (33.9) the intensity lessened, and 44 (12.2%) had a subjectively agreeable change of noise characteristics. No change was found in 157 cases (43.6%) and 25 (6.9%) experienced deterioration. There was no statistically significant difference between groups A and B (p > 0.05). Out of 68 patients with a positive expectation of HBO effects, 60.3% stated that the tinnitus had improved whereas only 47.2 and 19%, respectively, out of patients who underwent therapy with an indifferent (n = 271) or negative expectation (n = 21) reported an improvement. The influence of subjective expectation on the outcome was statistically significant (p < 0.05). Conclusion: The therapeutic effects of HBO on subjective tinnitus may be substantially influenced by psychological mechanisms.

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“…However, measurements of the perilymphatic oxygen tension have been made not only in experimental animals, but also in man [4,59]. Fisch [4] studied perilymphatic oxygen in patients with SD and found a decrease in the oxygen tension which could be counteracted by carbogen inhalations.…”

Section: Studies On Patients With Sdmentioning

confidence: 99%

Sudden Deafness – A Critical Evaluation of Pathogenesis and ‘Cure’

Hultcrantz¹

1999

Otorhinolaryngol Nova

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Objective: To discuss the possible etiology, pathogenesis and ‘cure’ of idiopathic sudden deafness (SD). Method: A review was made of different methods for the study of inner-ear physiology, especially its microcirculation, relating them to clinical evaluation and praxis for SD. Results: Cochlear blood flow (CBF) can be measured quantitatively with the microsphere method in animals. Direct qualitative measurements can be performed using the laser Doppler method. The CBF is partly autoregulated, but to a lesser degree than cerebral blood flow. Sympathetic stimulation decreases CBF up to 25%. Noise does not influence total CBF but seems to reduce blood flow in the lateral wall. Nicotinic acid, hemodilution and osmotic drugs increase the CBF proportionally. Carbogen increases the CBF but also creates acidosis. Treating patients with SD in accordance with these findings does not show any convincing effect compared to no treatment. Conclusion: More and more diseases have been identified which can have SD as a symptom. It is important to investigate to identify these treatable cases. Idiopathic cases should not be exposed to hazardous systemic medication or surgery. Local treatment through the round window will be the treatment modality for the future, but more basic research is necessary.

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Measurement of Oxygen Tension in Human Perilymph

Cited by 58 publications

References 2 publications

Sudden Deafness and Right-to-Left Shunts

Sudden Deafness and Right-to-Left Shunts

Hyperbaric Oxygen in Tinnitus: Influence of Psychological Factors on Treatment Results?

Sudden Deafness – A Critical Evaluation of Pathogenesis and ‘Cure’

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