Measurement of Prethrombotic Markers in the Assessment of Acquired Hypercoagulable States

López, Yolanda Ortega; Paloma, María José; Rifón, J.; Cuesta, B; Páramo, José A.

doi:10.1016/s0049-3848(98)00165-0

Cited by 68 publications

(47 citation statements)

References 33 publications

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“…[22][23][24] The half-life, approximately 90 minutes, makes its measurement in plasma more reliable than other markers for ongoing coagulation, such as thrombin-antithrombin complexes. However, whether F1ϩ2 provides a useful marker of atherosclerosis is still debated.…”

Section: Discussionmentioning

confidence: 99%

Prothrombin Fragment 1+2 Is Associated With Carotid Intima-Media Thickness in Subjects Free of Clinical Cardiovascular Disease

Páramo

Orbe

Beloqui

et al. 2004

Stroke

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Background and Purpose-Thrombin, a central enzyme in the clotting cascade, plays a role not only in thrombosis but also in the progression of atherosclerosis. We studied the relationship between prothrombin fragment 1ϩ2 (F1ϩ2), a specific marker of thrombin generation in vivo, and carotid intima-media thickness (IMT), an index of subclinical atherosclerosis. Methods-We examined 181 asymptomatic middle-aged subjects (mean age 55.6 years, 76.7% men) free of overt clinical atherosclerotic disease. F1ϩ2 was measured by enzyme-linked immunosorbent assay and IMT by duplex ultrasonography of carotid artery. Multiple linear regression analysis was used to assess the relationship between the 2 parameters. Results-Compared with individuals in the lowest tertile of F1ϩ2, those in the upper tertile (Ͼ0.55 nmol/L) showed significantly higher IMT (PϽ0.01). In correlation analysis, a positive relationship was found between plasma F1ϩ2 and carotid IMT. F1ϩ2 also correlated positively with cholesterol (PϽ0.008) and low-density lipoprotein cholesterol (PϽ0.005), but not with blood pressure or body mass index. In the multivariate analysis, the association of F1ϩ2 with carotid IMT remained significant (PϽ0.001) after adjustment for age, sex, body mass index, systolic blood pressure, cholesterol, diabetes, and smoking. Conclusions-In a population sample of adults without clinically overt atherosclerotic disease, the plasma levels of F1ϩ2 were significantly associated with carotid IMT, suggesting a relationship between thrombin generation and the development atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Prothrombin Fragment 1+2 Is Associated With Carotid Intima-Media Thickness in Subjects Free of Clinical Cardiovascular Disease

Páramo

Orbe

Beloqui

et al. 2004

Stroke

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“…These conditions display a significant increase both of the parameters indicating clotting activation (F1+2, TAT complex, FPA), and the markers of fibrinolysis (plasmin-alpha 2 antiplasmin complex and D-dimer). 62 In another report, antithrombin III (ATIII), D-dimer (DD), fibrinogen (F) in association to prothrombin time (PT), partial thromboplastin time (PTT) and platelet count, have been recorded in 286 patients with a new primary lung cancer, in order to evaluate the potential prognostic implications of coagulation disorders in this malignancy. The authors have shown that lower values of PT, in addition to higher values of F and DD were significantly predictive of an adverse outcome.…”

Section: Laboratory F Indingsmentioning

confidence: 99%

Coagulation and cancer: Implications for diagnosis and management

Loreto

Martinis

Corsi

et al. 2000

Pathol. Oncol. Res.

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“…Thrombin is a serine proteinase and is involved in hemostatic and thrombotic roles, from promotion and inhibition of clotting, to fibrinolysis, platelet activation, and inflammation. In the past, biochemical signs of coagulation activation in the acute phase of unstable angina or acute myocardial infarction (AMI) were demonstrated [1,2] and blood clotting activation markers were found to be independent risk factors for recurrence and long-term mortality [3][4][5][6]. In the last years the diffuse use of PCI and stenting stimulated several studies investigating primarily the role of platelet hyper-reactivity in determining clinical outcome [7,8].…”

Section: Introductionmentioning

confidence: 99%

Residual thrombin potential predicts cardiovascular death in acute coronary syndrome patients undergoing percutaneous coronary intervention

Attanasio

Marcucci

Gori

et al. 2016

Thrombosis Research

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Introduction: Thrombin generation (TG) is a central step of the coagulation system involved in hemostatic and thrombotic roles. Scarce data evaluating in the acute phase the association between TG and the risk of cardiovascular death of acute coronary syndrome (ACS) patients are available, in the era of percutaneous coronary intervention (PCI) and stenting with the use of dual antiplatelet treatment. Conclusions: ACS patients with a residual TG after PCI and stent implantation have a significantly higher risk of long-term cardiovascular death. These results might be useful in improving risk stratification for ACS patients and support the need of a tailored antithrombotic therapy.

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Measurement of Prethrombotic Markers in the Assessment of Acquired Hypercoagulable States

Cited by 68 publications

References 33 publications

Prothrombin Fragment 1+2 Is Associated With Carotid Intima-Media Thickness in Subjects Free of Clinical Cardiovascular Disease

Prothrombin Fragment 1+2 Is Associated With Carotid Intima-Media Thickness in Subjects Free of Clinical Cardiovascular Disease

Coagulation and cancer: Implications for diagnosis and management

Residual thrombin potential predicts cardiovascular death in acute coronary syndrome patients undergoing percutaneous coronary intervention

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