Measurement of Radial Peripapillary Capillary Density in the Normal Human Retina Using Optical Coherence Tomography Angiography

Mansoori, Tarannum; Sivaswamy, Jayanthi; Gamalapati, Jahnavi Sai; Agraharam, Satish Gooty; Balakrishna, Nagalla

doi:10.1097/ijg.0000000000000594

Cited by 60 publications

(43 citation statements)

References 16 publications

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“…In normal human eyes, blood supply to ONH is relying on posterior ciliary artery and central retinal artery, which also plays a role in blood supply of superficial RNFL layer of ONH. RPCs are straight, oriented superficial vessels that are paralleled to each other and arched to nourish RNFL around the ONH [33][34][35]. In the past decades, fluorescein angiography (FA) was used in the evaluation of ONH perfusion.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of microvascular network with optical coherence tomography angiography (OCTA) in branch retinal vein occlusion (BRVO)

et al. 2020

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Background: To evaluate changes of microvascular network of macular and peripapillary regions and to provide a quantitative measurement of foveal avascular zone (FAZ) in unilateral BRVO patients. Methods: Forty-seven unilateral BRVO patients and forty-seven normal controls were enrolled. A 3*3 mm scan centered on fovea followed by a 4.5*4.5 mm scan centered on optic nerve head (ONH) were obtained in BRVO eyes, fellow eyes and control eyes of each individual using OCTA (Optovue Inc., Fremont, CA, USA). Vessel density (VD) in superficial (SVC) and deep vascular complex (DVC) of macula and radial peripapillary capillary (RPC) were automatically calculated. Parameters of FAZ region including size, perimeter, acircularity index (AI) and foveal vessel density 300 (FD-300) were measured. Results: VDs of SCV and DVC were significantly lower, especially in affected regions, in BRVO eyes compared with fellow eyes (P < 0.05). BRVO affected eyes has larger FAZ size, FAZ perimeter, AI and lower FD-300 compared with fellow eyes (all P < 0.05). VD of SVC and FD-300 were lower in fellow eyes compared with normal control eyes (P < 0.05). The average vessel density in whole area and peripapillary area in BRVO eyes were significantly lower compared with fellow eyes (P < 0.05). VD of inside disc in fellow eyes was lower than normal eyes (P < 0.05). Conclusions: OCTA provided quantitative information of vascular changes in BRVO. FAZ in BRVO eyes showed significant morphological alterations and decreases of VD in surrounding area. Decreases of VD existed not only in SVC and DVC in macular region but also in RPCs in BRVO eyes. Unaffected eyes of unilateral BRVO showed vascular abnormalities in superficial retinal layer, peri-FAZ area and also peripapillary regions.

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Section: Discussionmentioning

confidence: 99%

Evaluation of microvascular network with optical coherence tomography angiography (OCTA) in branch retinal vein occlusion (BRVO)

et al. 2020

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“…In normal eyes of human, blood flow of the ONH is supplied by the posterior ciliary artery and central retinal artery, which is also the blood supply of superficial RNFL layer of ONH. RPCs are straight, oriented vessels which pursue a paralleled path to each other and arched up steeply to supply RNFL around the ONH [33][34][35]. Fluorescein angiography (FA) has been used to evaluate ONH perfusion for several decades.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Microvascular Network with Optical Coherence Tomography Angiography (OCTA) in Branch Retinal vein Occlusion (BRVO)

Chen

Yuan

Sun

et al. 2020

Preprint

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Purpose: To evaluate changes of microvascular network of macular and peripapillary regions and to provide a quantitative measurement of foveal avascular zone (FAZ) in unilateral BRVO patients. Methods: Forty-seven unilateral BRVO patients and forty-seven normal controls were enrolled. A 3*3 mm scan centered on fovea followed by a 4.5*4.5 mm scan centered on optic nerve head (ONH) were obtained in BRVO eyes, fellow eyes and control eyes of each individual using OCTA (Optovue Inc., Fremont, CA, USA). Vessel density (VD) in superficial (SVC) and deep vascular complex (DVC) of macula and radial peripapillary capillary (RPC) were automatically calculated. Parameters of FAZ region including size, perimeter, acircularity index (AI) and foveal vessel density 300 (FD-300) were measured. Results: VDs of SCV and DVC were significantly lower, especially in affected regions, in BRVO eyes compared with fellow eyes (P<0.05). BRVO affected eyes has larger FAZ size, FAZ perimeter, AI and lower FD-300 compared with fellow eyes (all P<0.05). VD of SVC and FD-300 were lower in fellow eyes compared with normal control eyes (P<0.05). The average vessel density in whole area and peripapillary area in BRVO eyes were significantly lower compared with fellow eyes (P<0.05). VD of inside disc in fellow eyes was lower than normal eyes (P<0.05). Conclusions: OCTA provided quantitative information of vascular changes in BRVO. FAZ in BRVO eyes showed significant morphological alterations and decreases of VD in surrounding area. Decreases of VD existed not only in SVC and DVC in macular region but also in RPCs in BRVO eyes. Unaffected eyes of unilateral BRVO showed vascular abnormalities in superficial retinal layer, peri-FAZ area and also peripapillary regions. Key words: optical coherence tomography angiography, retinal vasculature, foveal avascular zone, radial peripapillary capillary, branch retinal vein occlusion

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“…In normal human eyes, ONH is supplied by the posterior ciliary artery and central retinal artery, which is also the blood supply of superficial RNFL layer of ONH. RPCs are straight, oriented superficial vessels that are paralleled to each other and arched to supply RNFL around the ONH [33][34][35].…”

Section: Macular Vessel Densitymentioning

confidence: 99%

Evaluation of Microvascular Network with Optical Coherence Tomography Angiography (OCTA) in Branch Retinal vein Occlusion (BRVO)

Chen

Yuan

Sun

et al. 2020

Preprint

View full text Add to dashboard Cite

Purpose: To evaluate changes of microvascular network of macular and peripapillary regions and to provide a quantitative measurement of foveal avascular zone (FAZ) in unilateral BRVO patients. Methods: Forty-seven unilateral BRVO patients and forty-seven normal controls were enrolled. A 3*3 mm scan centered on fovea followed by a 4.5*4.5 mm scan centered on optic nerve head (ONH) were obtained in BRVO eyes, fellow eyes and control eyes of each individual using OCTA (Optovue Inc., Fremont, CA, USA). Vessel density (VD) in superficial (SVC) and deep vascular complex (DVC) of macula and radial peripapillary capillary (RPC) were automatically calculated. Parameters of FAZ region including size, perimeter, acircularity index (AI) and foveal vessel density 300 (FD-300) were measured. Results: VDs of SCV and DVC were significantly lower, especially in affected regions, in BRVO eyes compared with fellow eyes ( P <0.05). BRVO affected eyes has larger FAZ size, FAZ perimeter, AI and lower FD-300 compared with fellow eyes (all P <0.05). VD of SVC and FD-300 were lower in fellow eyes compared with normal control eyes ( P <0.05). The average vessel density in whole area and peripapillary area in BRVO eyes were significantly lower compared with fellow eyes ( P <0.05). VD of inside disc in fellow eyes was lower than normal eyes ( P <0.05). Conclusions: OCTA provided quantitative information of vascular changes in BRVO. FAZ in BRVO eyes showed significant morphological alterations and decreases of VD in surrounding area. Decreases of VD existed not only in SVC and DVC in macular region but also in RPCs in BRVO eyes. Unaffected eyes of unilateral BRVO showed vascular abnormalities in superficial retinal layer, peri-FAZ area and also peripapillary regions. Key words: optical coherence tomography angiography, retinal vasculature, foveal avascular zone, radial peripapillary capillary, branch retinal vein occlusion

show abstract

Measurement of Radial Peripapillary Capillary Density in the Normal Human Retina Using Optical Coherence Tomography Angiography

Cited by 60 publications

References 16 publications

Evaluation of microvascular network with optical coherence tomography angiography (OCTA) in branch retinal vein occlusion (BRVO)

Evaluation of microvascular network with optical coherence tomography angiography (OCTA) in branch retinal vein occlusion (BRVO)

Evaluation of Microvascular Network with Optical Coherence Tomography Angiography (OCTA) in Branch Retinal vein Occlusion (BRVO)

Evaluation of Microvascular Network with Optical Coherence Tomography Angiography (OCTA) in Branch Retinal vein Occlusion (BRVO)

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