The composition and content of necessary engineering-geological research providing accident-free operation of buildings and constructions in karst areas are considered. These studies include karst hazard assessment and rational selection of karst protection measures. The results of the prognostic assessment of karst sinkhole formation possibility on the territory of about 4 hectares, allocated for construction of the first stage of the complex of residential buildings of different numbers of floors in the northwest of Moscow, are presented. The basis was the results of site investigations, during which, in particular, several dozen boreholes were drilled to uncover soluble rocks. Karst hazard assessment included an in-depth analysis of engineering-geological conditions of the future construction site and adjacent territories and took into account the possibility of the occurrence of karst sinkholes of different genetic types in this city area. When building forecasts and karst risk assessment, calculated methods of probabilistic and deterministic character were used, allowing to determine the necessary conditions and parameters of karst sinkhole formation in quantitative terms. The results of the karst hazard assessment were considered when selecting karst protection methods.