Measurement of Redox Potential in Nanoecotoxicological Investigations

Tantra, Ratna; Cackett, A; Peck, R; Gohil, D D; Snowden, J

doi:10.1155/2012/270651

Cited by 15 publications

(11 citation statements)

References 13 publications

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“…The equations [9] and [10] account for their remarkable SOD-like activity, which is somewhat higher than for SOD enzyme (138), log k cat = 9.55. The E 1/2 for Ce IV /Ce III redox couple varies with medium, and in deionized water, it is * + 400 mV versus NHE (261). Neither charge nor reduction potential easily justifies…”

Section: Fe(iii) Porphyrinsmentioning

confidence: 94%

SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways

Batinić‐Haberle

Tovmasyan

Roberts

et al. 2014

Antioxidants & Redox Signaling

206

458

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Significance: Superoxide dismutase (SOD) enzymes are indispensable and ubiquitous antioxidant defenses maintaining the steady-state levels of O 2 $ -; no wonder, thus, that their mimics are remarkably efficacious in essentially any animal model of oxidative stress injuries thus far explored. Recent Advances: Structure-activity relationship (half-wave reduction potential [E 1/2 ] versus log k cat ), originally reported for Mn porphyrins (MnPs), is valid for any other class of SOD mimics, as it is dominated by the superoxide reduction and oxidation potential. The biocompatible E 1/2 of *+300 mV versus normal hydrogen electrode (NHE) allows powerful SOD mimics as mild oxidants and antioxidants (alike O 2 $ -) to readily traffic electrons among reactive species and signaling proteins, serving as fine mediators of redox-based signaling pathways. Based on similar thermodynamics, both SOD enzymes and their mimics undergo similar reactions, however, due to vastly different sterics, with different rate constants. Critical Issues: Although log k cat (O 2 $ -) is a good measure of therapeutic potential of SOD mimics, discussions of their in vivo mechanisms of actions remain mostly of speculative character. Most recently, the therapeutic and mechanistic relevance of oxidation of ascorbate and glutathionylation and oxidation of protein thiols by MnP-based SOD mimics and subsequent inactivation of nuclear factor jB has been substantiated in rescuing normal and killing cancer cells. Interaction of MnPs with thiols seems to be, at least in part, involved in up-regulation of endogenous antioxidative defenses, leading to the healing of diseased cells. Future Directions: Mechanistic explorations of single and combined therapeutic strategies, along with studies of bioavailability and translational aspects, will comprise future work in optimizing redox-active drugs. Antioxid. Redox Signal. 20, 2372Signal. 20, -2415

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Section: Fe(iii) Porphyrinsmentioning

confidence: 94%

SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways

Batinić‐Haberle

Tovmasyan

Roberts

et al. 2014

Antioxidants & Redox Signaling

206

458

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“…ORP values may also serve as a simple, rapid and real‐time proxy indicator for ozone concentration in water (Seki et al, 2017; Suslow, 2004) and is commonly used by aquaculture operators instead of ozone measurements through titration due to the complexity, cost and time required to process samples. Since contaminants in water (from salt, bacterial or Nutrient Broth media used in experiments) interfere with ORP readings, we conducted OPR reading on the NB generator in freshwater to eliminate biased ORP readings caused by ‘dirty’ water (Tantra et al, 2012). The pre‐trials were set up with the three NB gases (air, oxygen, ozone), replicated three times and ran for 15 minutes each.…”

Section: Methodsmentioning

confidence: 99%

Control ofVibrioparahaemolyticus(AHPND strain) and improvement of water quality using nanobubble technology

Nghia

Van

Giang

et al. 2021

Aquaculture Research

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Nanobubble technology is used in wastewater treatment, but its disinfectant properties in aquaculture have not been clearly demonstrated. This study investigated the ability of nanobubbles to reduce Vibrio parahaemolyticus (AHPND strain) and to improve water quality. Two laboratory experiments were conducted over a one‐week period, that is (a) assessing the effects of air and oxygen nanobubbles for 60 minutes per day and (b) comparing effects of ozone nanobubble treatments for 2, 4 and 6 minutes per day. Experiments were done in triplicate 100 L tanks with 15‰ saline water, inoculated with an initial bacterial concentration of 106 CFU/ml. At the end of experiment 1, the bacterial concentration of the air and oxygen nanobubble groups was counted for 69% and 46% of the control group respectively. At the end of experiment 2, the bacterial concentration of the 2‐, 4‐ and 6‐minute ozone nanobubble groups were counted for 23%, 2.2% and 0% of the control group respectively. Oxygen and ozone nanobubbles significantly increased oxygen reduction potential and oxygen values. Results indicate that under effective dosages nanobubbles can be used in the production farms to control V.parahaemolyticus and increase oxygen levels.

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“…Further electrical conductivity was measured by conductivity meter 304 (Systronics). The turbidity could be determined by the clarity of the solution after mixing 0.5 g each of the control and test samples in 20 mL of deionized water (Snowden et al 2012).…”

Section: Porosity (%)mentioning

confidence: 99%

Synthesis and characterization of crystalline carboxymethylated lignin–TEOS nanocomposites for metal adsorption and antibacterial activity

Kumari

Jha

2016

Bioresour. Bioprocess.

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Biodegradable carboxymethylated lignin-tetra ethoxysilane (TEOS) nanocomposites (CML-T) were synthesized using lignin extracted from rice straw (RS) followed by surface modification through carboxymethylation. Composites were characterized by UV-spectroscopy, Fourier transform infrared (FT-IR), scanning electron microscope (SEM), X-ray diffraction pattern (XRD), atomic absorption spectroscopy (AAS) and particle size distribution (PSD). The average diameter (D 50 ) of the CML-T composite particles was observed in the range of 160-560 nm. XRD spectra and SEM micrographs confirmed the high degree of crystallinity (peaks located at lower angle, 2θ = 12 and 22.0°) and porous nature of nanocomposites with increasing concentrations of TEOS. The composite exhibited nickel (Ni 2+ ) and cadmium (Cd 2+ ) adsorption up to 70.72 and 81.79 %, respectively in AAS analysis. The CML-T composite was investigated to assess their future applications as wound dressings and antimicrobial and packaging agents. Based on the antimicrobial properties and potential to remediate toxic heavy metals, the composites are proposed to be used for wastewater treatments, as packaging materials and for preparation of biofilters for environmental protection.

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Measurement of Redox Potential in Nanoecotoxicological Investigations

Cited by 15 publications

References 13 publications

SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways

SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways

Control ofVibrioparahaemolyticus(AHPND strain) and improvement of water quality using nanobubble technology

Synthesis and characterization of crystalline carboxymethylated lignin–TEOS nanocomposites for metal adsorption and antibacterial activity

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