Measurement of reticulocyte and red blood cell indices in the evaluation of anemia in inflammatory bowel disease

Oustamanolakis, Pantelis; Koutroubakis, Ioannis E.; Messaritakis, Ippokratis; Kefalogiannis, Georgios; Niniraki, Maria; Kouroumalis, Elias

doi:10.1016/j.crohns.2011.02.002

Cited by 52 publications

(50 citation statements)

References 29 publications

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“…This result indicates that the cumulative diagnosis of anemia increases with IBD disease duration. Thus, the higher rate of anemia identified in our cohort is likely due to this cumulative phenomenon when compared to cross-sectional prevalence studies from many other European countries (16)(17)(18)(19)(20). However, this increased rate of anemia may also be due to other factors; for instance, some of our patients were referrals and, thus, more complicated patients gathered in our cohort.…”

Section: Discussionmentioning

confidence: 55%

“…The higher anemia frequency in patients treated at university hospitals may also be related to the higher proportion of IBD patients with active and/or severe disease at university hospitals. Lastly, some differences in anemia frequency between different IBD centers may be attributed to different health systems operating in different countries; for example, the prevalence of anemia in Italian and Greek IBD patients was found to be higher than that in other Northern European countries (17,18).…”

Section: Discussionmentioning

confidence: 99%

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Incidence rate of anemia in inflammatory bowel diseases

Atuğ

Kani²,

Banzragch³

et al. 2016

Turk J Gastroenterol

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INTRODUCTIONInflammatory bowel diseases (IBD) are relapsing and remitting chronic intestinal disorders with extra-intestinal manifestations (EIM). IBD predominantly consist of two different clinical forms: Crohn's disease (CD) and ulcerative colitis (UC) (1,2).Anemia is a common complication in IBD and has a known negative impact not only on quality of life and but also on the ability to work (3,4). Thus, the detection and treatment of anemia in IBD patients deserves careful consideration with regards to the approach (5). Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are major causes of anemia in IBD patients (5,6). Vitamin B 12 and/or folate deficiency and drug-induced bone marrow suppression may represent other important contributing factors (7). In cross-sectional studies of IBD series, anemia was reported over a very wide range, from 6% to 74% (8,9). Indeed, the frequency of anemia differs among IBD patient populations and is dependent on hospitalization, IBD type, and remission status. Anemia has been reported to be more frequent in hospitalized patients and CD patient groups but less frequent in patients with clinical remission. In a recent review, the mean prevalence of anemia in an IBD patient population was 17% (16% in outpatients and 68% in hospitalized patients), with anemia occurring more frequently in patients with CD than in patients with UC (5,8). However, scarce information is available regarding the incidence rate of anemia over time in IBD cohorts. The anemia prevalence of Turkish IBD patients is also unknown.The main aim of this study was to determine the incidence rate and distribution of anemia types over time in an IBD patient cohort spanning 18 years from a single tertiary center in Turkey. Conclusion: This is the first study to report the incidence rate of anemia (103.45 per 1,000 patient-years) in a longterm cohort of IBD patients.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Incidence rate of anemia in inflammatory bowel diseases

Atuğ

Kani²,

Banzragch³

et al. 2016

Turk J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…These results were not predictable by us in the preparation period of the study because the patients had no additional symptoms or pathology besides IBD. However, mild anemia and low blood protein levels could be observed in IBD patients as a result of chronic blood loss via the gastrointestinal tract, malabsorption, and chronic inflammation (36). These findings related to malabsorption were more severe in Crohn's disease than that in ulcerative colitis because of differences in disease localization in their gastrointestinal tracts.…”

Section: Discussionmentioning

confidence: 62%

Visual evoked potentials and pulse wave velocity in inflammatory bowel disease

Aytaç

Büyüktaş²,

Baysal³

et al. 2015

Turk J Gastroenterol

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Background/Aims: Data about the effects of inflammatory bowel disease (IBD) on various functions of the nervous and cardiovascular systems are limited. In this study, the visual neuronal and cardiovascular functions of patients with IBD were evaluated by measuring visual evoked potentials (VEP) and pulse wave velocity (PWV), respectively. Materials and Methods: There were three study groups: the Crohn's disease (CD) group (n=25), the ulcerative colitis (UC) group (n=30), and a healthy control (C) group (n=25). The exclusion criteria were as follows: patients with IBD were in remission, had no extra-intestinal manifestations of the disease, had no additional chronic disease(s), and had been receiving medical treatment for their IBD without any previous surgical intervention. VEP amplitudes (mV) and the N2 and P2 latencies (ms) were recorded for visual-neuronal analysis of all study groups. For cardiovascular assessment in all study groups, PWV was measured noninvasively as follows: the carotid-femoral PWV with the Complior Colson device (The authors have no conflict of interest.) and the PWV along the aorta with two ultrasound strain-gauge pressure-sensitive transducers (TY-306 Fukuda pressure-sensitive transducers -Fukuda Denshi Co, Tokyo, Japan) fixed transcutaneously over the course of a pair of arteries separated by a known distance. The right femoral and right common carotid arteries were the ones used. Results: The PWV levels of the CD and UC groups were significantly higher than those in the C group (p<0.001). In the bilateral recording of the VEP, the N2 latencies of the CD (p<0.05) and UC (p<0.01) groups were significantly longer than those in the C group. Conclusion: In this study, we showed vascular and visual neuronal impairments at a subclinical stage in patients with both types of IBD.

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“…provides information about the cellular immune system activation [53][54][55][56]58] for the purpose of diagnosis, successful treatment and prognosis of inflammatory states, including atherosclerosis [56,59,60], malignancies (cancer and leukemia) [61], vascular (cardiovascular-, brain vascular, peripheral artery vascular) [59,62,63], neurological, autoimmune, and many other socially important diseases [e.g. acquired immune deficiency syndrome (AIDS); other viral and bacterial infections], aging-related disorders, including MS [56,57,60,[64][65][66][67][68][69][70].…”

Section: Discussionmentioning

confidence: 99%

Medical significance of simultaneous application of red blood cell distribution width (RDW) and neopterin as diagnostic/prognostic biomarkers in clinical practice

Zvetkova

Fuchs²

2017

Pteridines

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In our individual and collaborative studies, we have played a part in pioneering investigations on the usefulness of biomarkers -red blood cell distribution width (RDW) and neopterin. This mini review includes historical data on the topic and is related to the first contributions in this field, as well as to the possibilities for further improvement and simultaneous application of RDW and neopterin measurements in the prevention, prognosis and treatment of a great number of socially important disease conditions (arterial, cardiovascular, brain vascular, peripheral artery diseases, inflammations, autoimmune states, cancers and leukemias, addictions, etc.). When comparing the results obtained with the immunobiochemical biomarker neopterin with RDW, they are reported to be very similar as independent predictors of the same pathological states in the human body although their biomedical origins are very different. Both the parameters were until now successfully, but only separately used in medical practice. The combined use of these two biomarkers can shed some more light on their interrelationships and provide some clues as to how the interaction between immune system activation and red blood cells biology are intertwined.

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Measurement of reticulocyte and red blood cell indices in the evaluation of anemia in inflammatory bowel disease

Abstract: RDW, RSF and RDWR, could be useful markers for the evaluation of anemia and disease activity in IBD.

Cited by 52 publications

References 29 publications

Incidence rate of anemia in inflammatory bowel diseases

Incidence rate of anemia in inflammatory bowel diseases

Visual evoked potentials and pulse wave velocity in inflammatory bowel disease

Medical significance of simultaneous application of red blood cell distribution width (RDW) and neopterin as diagnostic/prognostic biomarkers in clinical practice

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