Measurement of Retinal Nerve Fiber Layer Thickness and Macular Volume for Glaucoma Detection Using Optical Coherence Tomography

Ojima, T.; Tanabe, Teruyo; Hangai, Masanori; Yu, Saiyuu; Morishita, Shiho; Yoshimura, Nagahisa

doi:10.1007/s10384-006-0433-y

Cited by 103 publications

(96 citation statements)

References 14 publications

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“…23 IC 95% 0,148-0,382). Table 2 shows the relationship between quadrantic and hemifield macular thickness parameters and the corresponding VF sensitivity loss.…”

Section: Resultsmentioning

confidence: 99%

“…Since Zeimer et al (14) proposed to use macular thickness as an indicator of glaucoma severity, several studies have investigated this idea using technologies to measure retinal thickness such as OCT (18)(19)(20)(21)(22)(23)(24) . Such studies were conducted based on the theory that the macular thickness might be superior to circumpapillary RNFL for quantification of axonal loss, because retinal ganglion cell bodies are 10 to 20 times the diameter of their axons and because the retinal ganglion cell layer is more than one cell thick in the macula (25) .…”

Section: Discussionmentioning

confidence: 99%

“…Such studies were conducted based on the theory that the macular thickness might be superior to circumpapillary RNFL for quantification of axonal loss, because retinal ganglion cell bodies are 10 to 20 times the diameter of their axons and because the retinal ganglion cell layer is more than one cell thick in the macula (25) . However, despite the confirmation that macular thickness is in fact reduced in patients with glaucoma, several studies have reported circumpapillary RNFL thickness to be a more sensitive detector of glaucoma than macular thickness (19,23,(26)(27) . This may in part be due to limitations inherent in the OCT software which is restricted to analyzing macular data for the entire retina, leading to reduced specificity.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome

Moura¹,

Costa-Cunha²,

Malta³

et al. 2010

Arq. Bras. Oftalmol.

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Purpose: To correlate visual field sensitivity (VFS) loss on standard automated perimetry (SAP) and quadrantic macular thickness on optical coherence tomography (OCT) in patients with permanent temporal hemianopia from chiasmal compression. Methods: Forty eyes from 40 patients with chiasmal compression and 40 healthy eyes were submitted to standard automated perimetry and Stratus-OCT scanning. Raw data of the fast macular thickness scanning protocol were exported and macular thickness measurements were recorded and averaged for each quadrant and half of the central area. The correlation between visual field sensitivity loss and optical coherence tomography measurements was tested with Pearson's correlation coefficients and with linear regression analysis. Results: A significant association was found between each macular thickness parameter and the corresponding central VF mean sensitivity. The strongest association was observed between superonasal macular thickness and the inferotemporal mean defect measured both in decibel (R=0.47; p=0.001) and in 1/Lambert (R=0.59; p<0.0001) units. Conclusion: Stratus-OCT-measured macular thickness was topographically related with visual field sensitivity loss in patients with temporal hemianopia from chiasmal compression. Such measurements could prove clinically useful in the diagnosis and follow-up of patients with chiasmal compression. ClinicalTrial.gov identifier number: NCT0039122.Keywords: Tomography, optical coherence; Perimetry; Optic atrophy; Optic chiasm; Hemianopsia; Visual fields RESUMO Objetivo: Avaliar a correlação entre o defeito de campo visual ao exame de perimetria computadorizada e a espessura macular quadrântica ao exame de tomografia de coerência óptica (OCT) em pacientes com hemianopsia temporal permanente causada por compressão quiasmática. Métodos: Quarenta olhos de 40 pacientes com compressão quiasmática e 40 olhos de 40 indivíduos controles foram submetidos aos exames de perimetria computadorizada e tomografia de coerência óptica. Dados não processados foram exportados e as medidas de espessura macular foram calculadas para cada quadrante e metade da área macular central. A correlação entre o defeito campimétrico e as medidas de espessura macular foi avaliada por coeficiente de correlação de Pearson e por análise de regressão linear. Resultados: Associação significante foi encontrada entre os parâmetros de espessura macular e seus respectivos defeitos campimétricos. A correlação mais forte foi encontrada entre o parâmetro espessura macular nasal superior e o defeito campimétrico médio temporal inferior medido em decibel (R=0,47; p=0,001) e em 1/Lambert (R=0,59; p<0,0001). Conclusão: Medidas de espessura macular avaliada através da tomografia de coerência óptica foi topograficamente relacionada ao defeito campimétrico em pacientes com hemianopsia temporal por compressão quiasmática. Estas medidas podem provar a importância clínica no diagnóstico e seguimento dos pacientes com compressão quiasmática. ClinicalTrial.gov identifier number: NCT00391...

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“…23 IC 95% 0,148-0,382). Table 2 shows the relationship between quadrantic and hemifield macular thickness parameters and the corresponding VF sensitivity loss.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome

Moura¹,

Costa-Cunha²,

Malta³

et al. 2010

Arq. Bras. Oftalmol.

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“…Our results also provide new data that APAC results in a decrease in outer macular volume, though this was not associated with significant visual field defects or optic disc pallor. Earlier studies indicate that macular thickness is decreased in both paediatric 20,21 and adult glaucoma [22][23][24][25] patients. We found that macular RNFL loss in APAC eyes was mild and o10% compared with fellow eyes, hence was unlikely to be extensive enough to cause visual field defects on standard white-on-white perimetry.…”

Section: Discussionmentioning

confidence: 99%

Changes in retinal nerve fibre layer, optic nerve head morphology, and visual field after acute primary angle closure

Sng

See

Ngo

et al. 2011

Eye

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Aims/Purpose To determine and correlate the long-term changes in retinal nerve fibre layer (RNFL) thickness, optic nerve head (ONH) morphology, and visual fields after a single episode of acute primary angle closure (APAC). Methods This was a cross-sectional comparative study of patients at National University Hospital (Singapore) from 2000 to 2006 after an episode of unilateral APAC. The peripapillary and macular RNFL were measured using Stratus optical coherence tomography (OCT) and ONH configuration was assessed using Heidelberg Retina Tomography (HRT)-III. Humphrey perimetry was also performed, and the presence of disc pallor was noted. APAC eyes were compared with fellow eyes as matched controls. Results Twenty-five patients were assessed at a median of 33 months (range, 11-85 months) after APAC. OCT showed that there was a reduction in the peripapillary and outer macular RNFL thickness in APAC eyes compared with controls. Humphrey perimetry revealed significantly reduced mean deviation (P ¼ 0.006) and increased pattern standard deviation (P ¼ 0.045) in APAC eyes compared with controls. HRT-III showed no difference in mean rim area, rim volume, or cup-disc ratio between APAC eyes and controls. Disc pallor was present in nine APAC eyes (36%) but was absent in fellow eyes (P ¼ 0.002), and was associated with peripapillary RNFL thinning, visual field loss, and an increased interval between the onset of symptoms and normalization of intraocular pressure (P ¼ 0.023). Conclusion APAC results in peripapillary and outer macular RNFL loss, visual field defects, and optic disc pallor, even in cases in which the ONH configuration remains unchanged.

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“…Glaucoma diagnosis is made by using anterior chamber angle measurement. Retinal Nerve Fiber Layer (RNFL) thickness and macular volume is computed for glaucoma diagnosis using OCT images 6 . The variance analysis and Bonferroni's correction are used for determination of RNFL thickness and macular volume.…”

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confidence: 99%

Automated Early Detection of Glaucoma in Wavelet Domain Using Optical Coherence Tomography Images

Rajan¹,

Ramesh²

2015

Biosci., Biotech. Res. Asia

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Glaucoma is a chronic eye disease now-a-days that leads to visual impairment and blindness worldwide. Neurodegeneration of the optic nerve in association with changes in the parapapillary region induces glaucoma. Hence, the premature detection of optic nerve damage may permit early detection of glaucoma. In this paper, an image classification system is developed for early stage glaucoma diagnosis based on Discrete Wavelet Transform (DWT) using Optical Coherence Tomography (OCT) images. After DWT decomposition, significant wavelet coefficients are selected using t-test class separability criteria and fed into the Support Vector Machine (SVM) classifier for automated diagnosis. The proposed approach effectively classifies the glaucomatous and non glaucomatous image with accuracy of 90.75%, sensitivity of 91.79%, and specificity of 89.71%.

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Measurement of Retinal Nerve Fiber Layer Thickness and Macular Volume for Glaucoma Detection Using Optical Coherence Tomography

Abstract: Both peripapillary RNFL thickness and macular volume were decreased even in the early stage of glaucoma. Average RNFL thickness had greater diagnostic power than macular volume.

Cited by 103 publications

References 14 publications

Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome

Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome

Changes in retinal nerve fibre layer, optic nerve head morphology, and visual field after acute primary angle closure

Automated Early Detection of Glaucoma in Wavelet Domain Using Optical Coherence Tomography Images

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