Measurement of squalene in human tissues and plasma: validation and application

Liu, G C; Ahrens, E. H.; Schreibman, Paul H.; Crouse, John R.

doi:10.1016/s0022-2275(20)37014-0

Cited by 121 publications

(15 citation statements)

References 23 publications

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“…Figure 6a shows the relation between gA single-channel lifetime (t) and the thickness of monoacylglyceride/ squalene bilayers (Elliott et al 1983;from Lundbaek & Andersen 1999). (Bilayers formed using squalene in the bilayer-forming solution are virtually hydrocarbon-free (Simon et al 1977;White 1978), and squalene seems to be a universal component of living cells, even red blood cells (Liu et al 1976). )…”

Section: Channel -Bilayer Mismatchmentioning

confidence: 99%

Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes

Lundbæk

Collingwood

Ingólfsson

et al. 2009

J. R. Soc. Interface.

287

392

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Membrane protein function is regulated by the host lipid bilayer composition. This regulation may depend on specific chemical interactions between proteins and individual molecules in the bilayer, as well as on non-specific interactions between proteins and the bilayer behaving as a physical entity with collective physical properties (e.g. thickness, intrinsic monolayer curvature or elastic moduli). Studies in physico-chemical model systems have demonstrated that changes in bilayer physical properties can regulate membrane protein function by altering the energetic cost of the bilayer deformation associated with a protein conformational change. This type of regulation is well characterized, and its mechanistic elucidation is an interdisciplinary field bordering on physics, chemistry and biology. Changes in lipid composition that alter bilayer physical properties (including cholesterol, polyunsaturated fatty acids, other lipid metabolites and amphiphiles) regulate a wide range of membrane proteins in a seemingly non-specific manner. The commonality of the changes in protein function suggests an underlying physical mechanism, and recent studies show that at least some of the changes are caused by altered bilayer physical properties. This advance is because of the introduction of new tools for studying lipid bilayer regulation of protein function. The present review provides an introduction to the regulation of membrane protein function by the bilayer physical properties. We further describe the use of gramicidin channels as molecular force probes for studying this mechanism, with a unique ability to discriminate between consequences of changes in monolayer curvature and bilayer elastic moduli.

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Section: Channel -Bilayer Mismatchmentioning

confidence: 99%

Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes

Lundbæk

Collingwood

Ingólfsson

et al. 2009

J. R. Soc. Interface.

287

392

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“…Administration of olive oil promoted collagen synthesis, decreased catecholamine synthesis, and inhibited ROS production, lipid peroxidation, protein carbonylation, and MMP-8 levels in stressed mouse dorsal skin [13]. Squalene, a polyunsaturated aliphatic hydrocarbon found in shark liver oil and olive oil, is an important intermediate in the endogenous synthesis of cholesterol [130]. In a clinical study, oral supplementation with squalene substantially increased procollagen levels and reduced facial wrinkles and erythema, keratinocytic apoptosis, and thymine dimer levels in facial skin [131].…”

Section: Fatty Acidsmentioning

confidence: 99%

Boosting the Photoaged Skin: The Potential Role of Dietary Components

et al. 2021

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Skin photoaging is mainly induced by ultraviolet (UV) irradiation and its manifestations include dry skin, coarse wrinkle, irregular pigmentation, and loss of skin elasticity. Dietary supplementation of nutraceuticals with therapeutic and preventive effects against skin photoaging has recently received increasing attention. This article aims to review the research progress in the cellular and molecular mechanisms of UV-induced skin photoaging. Subsequently, the beneficial effects of dietary components on skin photoaging are discussed. The photoaging process and the underlying mechanisms are complex. Matrix metalloproteinases, transforming growth factors, skin adipose tissue, inflammation, oxidative stress, nuclear and mitochondrial DNA, telomeres, microRNA, advanced glycation end products, the hypothalamic–pituitary–adrenal axis, and transient receptor potential cation channel V are key regulators that drive the photoaging-associated changes in skin. Meanwhile, mounting evidence from animal models and clinical trials suggests that various food-derived components attenuate the development and symptoms of skin photoaging. The major mechanisms of these dietary components to alleviate skin photoaging include the maintenance of skin moisture and extracellular matrix content, regulation of specific signaling pathways involved in the synthesis and degradation of the extracellular matrix, and antioxidant capacity. Taken together, the ingestion of food-derived functional components could be an attractive strategy to prevent skin photoaging damage.

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“…Squalene (C 30 H 50 ), which is extracted from shark liver oil, is an important substance for cholesterol biosynthesis. It is mainly synthesized in the livers of animals and abundant in abdominal adipose tissue, subcutaneous adipose tissue, lymph nodes, pancreas, and cardiac muscle (Liu et al, 1976). In particular, squalene has six double bonds, which gives it the ability to easily combine with oxygen ions F I G U R E 7 Fraction compound of Prunus mume fruit ethanol extract identified by high-performance liquid chromatography.…”

Section: Identification Of Fraction Code D Substance By Nmrmentioning

confidence: 99%

Isolation and identification of squalene as an antioxidative compound from the fruits of Prunus mume

Kim

Huh

2021

J. Food Process. Preserv.

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Prunus mume contains an abundance of minerals such as free sugars, sitosterol, calcium, and iron. It is also an alkaline food that has high levels of organic acids, including succinic acid, citric acid, malic acid, and tartaric acid. P. mume has various functionalities as a health food supplement due to its beneficial effects on fatigue, aging, hangovers, and abnormal defecation (Han et al., 2001;Ko et al., 2007;Park et al., 2013). In addition, it contains rutin, lyoniresinol, and mumefural and has bioactive effects such as anti-cancer, anti-diabetes, and anti-hypertensive activities (Hwang, 2008). Therefore, various processed products based on P. mume fruits are being developed. Studies on the physiological activity of P. mume have previously focused on its antioxidant and anti-microbial

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Measurement of squalene in human tissues and plasma: validation and application

Cited by 121 publications

References 23 publications

Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes

Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes

Boosting the Photoaged Skin: The Potential Role of Dietary Components

Isolation and identification of squalene as an antioxidative compound from the fruits of Prunus mume

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