Measurement of Teicoplanin Concentration With Liquid Chromatography-Tandem Mass Spectrometry Method Demonstrates the Usefulness of Therapeutic Drug Monitoring in Hematologic Patient Populations

Abstract

The linear range was 3.9-52.9 mg/L. The imprecision was less than 12%, the limits of detection and quantification were less than 0.13 and 0.72 mg/L, respectively. The sample carry-over and ion suppression were insignificant. In the standard dose group, the median teicoplanin concentrations were 7.5 mg/L (days 3-5) and 8.9 mg/L (on days 6-8) and the proportion of trough levels achieving ≥10 mg/L, was 20% (days 3-5) and 38% (days 6-8), respectively. In the TDM-guided individualized dose group, median teicoplanin concentration was higher (16.9 mg/L), and the proportion of trough levels ≥10 mg/L was also higher (77%) when compared with the standard dose group CONCLUSIONS:: Based on these results, the present UHPLC-MS/MS method can be considered suitable for routine TDM of teicoplanin. Also based on the insufficient trough teicoplanin concentrations achieved with standard dose regimen, and the higher trough teicoplanin concentrations achieved with TDM-guided individualized dose regimen, this study highlights the importance of TDM of teicoplanin, especially in high-risk patient groups.

<p>A nationwide utilization survey of therapeutic drug monitoring for five antibiotics in South Korea</p>

“…As many as 20% of patients treated with aminoglycosides experience ototoxicity and acute kidney injury due to acute tubular necrosis, a relatively common complication of aminoglycoside therapy, defined as a rise in the serum creatinine concentration of more than 0.5–1 mg/dL (44 to 88 umol/L) or a 50 percent increase in serum creatinine concentration from baseline 9–11. The use of glycopeptides has rapidly increased in the past 10 years because of the exponential spread of methicillin-resistant Staphylococcus aureus (MRSA), while teicoplanin, another glycopeptide antibiotic, has become increasingly popular 12. The role of TDM in teicoplanin use is primarily to ensure treatment efficacy 12…”

“…The use of glycopeptides has rapidly increased in the past 10 years because of the exponential spread of methicillin-resistant Staphylococcus aureus (MRSA), while teicoplanin, another glycopeptide antibiotic, has become increasingly popular 12. The role of TDM in teicoplanin use is primarily to ensure treatment efficacy 12…”

Identification of a frit-related sample carryover in newborn screening by tandem mass spectrometry

“…DBS QC samples were punched out into 3.2 mm diameter disks and extracted by the extraction working solution containing the internal standards for each analyte, based on the manufacturer’s instructions. The high (H) and low (L) QC samples were injected in the following sequence H1-H2-H3-H4-L1-L2-L3-L4, and carryover (%) was calculated as follows [2] : …”

Therapeutic drug monitoring of glycopeptide antimicrobials: An overview of liquid chromatography-tandem mass spectrometry methods

“…To the best of our knowledge, four LC-MS/MS methods, summarized in Table 2 , developed for quantifying teicoplanin have been developed and applied to human samples [52] , [56] , [65] , [66] . All of these methods quantified teicoplanin in serum or plasma samples.…”