Measurement of Tennessee antigen, carcinoembryonic antigen, tissue polypeptide antigen and alpha-feto-protein in body fluids associated with pregnancy

Oehr, P.; Bellmann, O.; Hamann, Dirk

doi:10.1016/s0009-9120(82)90313-7

Cited by 12 publications

(7 citation statements)

References 4 publications

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“…1). This observation extends the result of Oehr et al [13], who found that in 20 seminal plasma the TPA values were higher than in serum of healthy blood donors. No quantitative data are available from this study [13].…”

Section: Discussionsupporting

confidence: 91%

“…This observation extends the result of Oehr et al [13], who found that in 20 seminal plasma the TPA values were higher than in serum of healthy blood donors. No quantitative data are available from this study [13]. The experiments in this paper showed that TPA is taken up by live spermatozoa, and it can be postulated that TPA is one of the so-called sperm-coating antigens.…”

Section: Discussionsupporting

confidence: 91%

“…This subfraction has been used for most of the work on the chemistry of TPA and for the development of a radioimmunoassay [4,10-12,161. Besides serum, TPA has been determined in urine [ l l ] , ascites fluid [ l ] , pleural effusion [3], amniotic fluid, and cord blood [2]. The short report of Oehr et al [13] seems to be the only observation on the occurrence of TPA in semen.…”

Section: Introductionmentioning

confidence: 99%

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Tissue Polypeptide Antigen Immunoreactivity in Human Semen

Lizana¹,

Eneroth²,

Bygdeman³

1984

Archives of Andrology

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A substance with TPA immunoreactivity is present in human seminal plasma. This seminal plasma TPA shows immunological similarity with TPA isolated from a pool of carcinoma tumors. TPA is taken up by live spermatozoa and it cannot be easily washed out. Split-ejaculate studies suggest that TPA originates mainly from the prostate. TPA is not correlated with the spermatozoa count, total number of spermatozoa, percentage of normal spermatozoa, or forward motility. The mean seminal plasma concentration of TPA in morphologically normal ejaculates is 14,531 U/liter. No difference was found in the TPA levels between the normal group and various groups of patients under investigation for involuntary infertility.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Tissue Polypeptide Antigen Immunoreactivity in Human Semen

Lizana¹,

Eneroth²,

Bygdeman³

1984

Archives of Andrology

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“…The main subunit B1, has been found in foetal tissues at 10, 17, and 24 weeks [37], and with higher concentration in liver, lung, stomach, intestine, kidney and meconium [38]. Increased serum levels of TPA may be present in several nonmalignant diseases: bacterial and viral infections [39], acute hepatitis [40], pregnancy (with particularly high values in the placenta and amniotic fluid [41,42]), and autoimmune disorders [43]. High levels of TPA have been reported in serum and urine of patients with several tumours, such as carcinoma of the breast, lung, stomach and colonrectum, pancreas, bladder, uterus, prostate, melanoma and lymphoma [44].…”

Section: Tissue Polypeptide Antigenmentioning

confidence: 99%

Serum tumour markers in lung cancer: history, biology and clinical applications

Ferrigno¹,

Buccheri²,

Biggi³

1994

Eur Respir J

102

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S Se er ru um m t tu um mo ou ur r m ma ar rk ke er rs s i in n l lu un ng g c ca an nc ce er r: : h hi is st to or ry y, , b bi io ol lo og gy y a an nd d c cl li in ni ic ca al l a ap pp pl li ic ca at ti io on ns s Several tumour markers have been studied in lung cancer. Unfortunately, none of these appear to be sufficiently sensitive and specific to be reliable for screening and diagnostic purposes. However, there is a body of evidence which proves that at least some of these substances may be useful in the evaluation of the course and prognosis of the disease.This review presents data concerning the most studied and interesting tumour markers in lung cancer.

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“…As such it has been used in immunomorphological definition of epithelial compartments of the cervical mucosa [5]. TPA occurs in many tumors, in secretions, in amniotic fluid and in homogenized placental tissue [6][7][8][9][10][11][12][13], It occurred to us that measurement of TPA in maternal serum might indicate placental function and thus well-being.…”

Section: Introductionmentioning

confidence: 99%

Maternal and Cord Serum Levels of Tissue Polypeptide Antigen (TPA) in Normal Pregnancies

Bremme¹,

Eneroth²,

Nilsson

et al. 1985

Gynecol Obstet Invest

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The tumor antigen and cytoskeleton protein tissue polypeptide antigen (TPA) have been determined in maternal serum throughout pregnancy. TPA levels in serum from pregnant women (n = 70) were not different from those in nonpregnant women (n = 61) until pregnancy week 28, from which time levels increased until parturition. Duplex pregnancies (n = 7) had higher serum TPA concentrations than simplex pregnancies, which was significant in pregnancy weeks 28 (p < 0.014) and 32 (p = 0.05). Maternal serum TPA concentrations did not change during abortion or parturition and the mixed umbilical blood concentration of TPA equaled that in the mother’s serum just after parturition. The correlation between placenta weight and maternal serum TPA levels was significant (p = 0.025). The decline of TPA after labor indicated a t_½ for serum TPA of 7.5 days.

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Measurement of Tennessee antigen, carcinoembryonic antigen, tissue polypeptide antigen and alpha-feto-protein in body fluids associated with pregnancy

Cited by 12 publications

References 4 publications

Tissue Polypeptide Antigen Immunoreactivity in Human Semen

Tissue Polypeptide Antigen Immunoreactivity in Human Semen

Serum tumour markers in lung cancer: history, biology and clinical applications

Maternal and Cord Serum Levels of Tissue Polypeptide Antigen (TPA) in Normal Pregnancies

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