Measurement of the Active Iodine Stores and Daily Hormonal Output of the Intact Human Thyroid*

X-ray fluorescent scanning of the thyroid

“…Nevertheless, although no information as to the nature of what one is measuring by XRF can be gathered, these studies bring into light two aspects of the importance of assessing TIT I in these circumstances.. For instance, one can conclude from the data published by Haberman et ai, (48,49), in keeping with our own experience (50), that when the iodine containing agent has been withdrawn, the urinary iodide excretion reaches normal levels long before the ITI. Nevertheless, although no information as to the nature of what one is measuring by XRF can be gathered, these studies bring into light two aspects of the importance of assessing TIT I in these circumstances.. For instance, one can conclude from the data published by Haberman et ai, (48,49), in keeping with our own experience (50), that when the iodine containing agent has been withdrawn, the urinary iodide excretion reaches normal levels long before the ITI.…”

“…It is also generally admitted that hyperthyroidism due to iodide will preferentially set in in already diseased glands (44). Reports start to appear that demonstrate by means of XRF the accumulations of iodine in the gland during treatment with various iodine containing drugs (36,47,48,49). There is however no reason to believe that the peripheral effects of these drugs can result in dysthyreosis, stressing the role of the liberated iodide itself, either at the periphery or in the thyroid.…”

“…Iodine deficiency is seen to be the main manifestation factor of the non-toxic gOiter (14), even though other goitrogens may act additionally under iodine deficiency (24). The iodine content of normal thyroid and goiter tissue has become more interesting since different intrathyroidal iodine compartments are known, among which only the exchangeable pool may be assessed by short term radioiodine studies (4,47,48), and secondly because the reduced iodine concentration of thyroid tissue possibly represents a permissive factor for the proliferative response to TSH (5,8). Up to now the iodine concentration data of thyroid tissue have mostly been derived from the chemical analysis of specimens obtained during surgery or at autopsy (17,28).…”

Total Thyroidal Content of Iodine in Thyrotoxic Patients Measured by in Vivo Neutron Activation Analysis

“…The measurement of the TCI in viuo in man is not simple. Radioisotopic methods such as those introduced by Berson & Yalow (1954) and developed by Nodine et al (1957) measure only the exchangeable fraction of total organic iodine in the thyroid which has reached 'equilibrium' with the tracer during the measurement period. Particular difficulties arise in applying this method to thyrotoxic patients.…”

Normal Blood Values of an Adult Male Perodicticus potto with Comparative Data from Other Primates

“…Lemaire and Goffart [1974] (PBI, TSR); AÍ. mulatto: Auclair et al [19701 (PBI, T"), Stolte et al [1966] (TSR); Homo sapiens: Refetoff et al [1970] (PBI, T4), Nodine et al [1957) (TSR).…”