Total Thyroidal Content of Iodine in Thyrotoxic Patients Measured by in Vivo Neutron Activation Analysis

Robertson, Ian; Boddy, K.; Hooper, M.; Stevenson, R. D.; McGhie, Tony K.; Alexander, W. D.; Wilson, Graham M.

doi:10.1111/j.1365-2265.1976.tb02826.x

Cited by 13 publications

(2 citation statements)

References 12 publications

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“…Iodine is an essential microelement that was closely associated with the synthesis of thyroid hormone [ 1 ]. Several thyroid disorders can lead to the abnormal iodine intake and metabolism, and subsequently result in the changes of the iodine concentration (IC) and total iodine content (TIC) within the thyroid gland (TG) [ 2 , 3 ]. Previously, Binh et al have reported that the IC of TG correlated negatively with the iodine uptake at 3 h after oral administration of 123 I in patients with Graves disease [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of sex, age and thyroid function indices on dual-energy computed tomography-derived quantitative parameters of thyroid in patients with or without Hashimoto’s thyroiditis

Geng

Zhou²,

Su³

et al. 2023

BMC Med Imaging

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Purpose To study the influence of sex, age and thyroid function indices on dual-energy computed tomography (DECT)-derived quantitative parameters of thyroid in patients with or without Hashimoto’s thyroiditis (HT). Material and methods A total of 198 consecutive patients who underwent DECT scan of neck due to unilateral thyroid lesions were retrospectively enrolled. Iodine concentration (IC), total iodine content (TIC) and volume of normal thyroid lobe were calculated. Influences of sex, age and thyroid function indices on DECT-derived parameters in overall study population, subgroup patients with, and those without HT were assessed using Mann–Whitney U test, Student’s T-test, and Spearman correlation analyses, respectively, as appropriate. Results HT group showed significantly lower IC and TIC, while higher volume than No-HT group (all p < 0.001). The volume was larger in male than that in female in overall study population and No-HT group (p = 0.047 and 0.010, respectively). There was no significant difference in any DECT-derived parameters between low (≤ 35 years) and high (> 35 years) age group in all three groups (all p > 0.05). TPOAb and TgAb correlated positively with IC and TIC, and negatively with volume in overall study population (all p < 0.05). TPOAb and TgAb also correlated positively with IC in HT group (p = 0.002 and 0.007, respectively). Conclusion DECT-derived parameters of thyroid differed significantly between patients with and without HT. Sex and thyroid function indices could affect the DECT-derived parameters. Aforementioned physiological factors should be considered when analyzing the DECT-derived parameters of thyroid.

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Section: Introductionmentioning

confidence: 99%

Influence of sex, age and thyroid function indices on dual-energy computed tomography-derived quantitative parameters of thyroid in patients with or without Hashimoto’s thyroiditis

Geng

Zhou²,

Su³

et al. 2023

BMC Med Imaging

View full text Add to dashboard Cite

show abstract

“…Using the validated X-ray fluor¬ escence method, neutron activation analysis, radioimmu¬ noassay and eerie arsenite reaction method, the average iodine concentration of normal human thyroids in 12 studies reported in the literature was 73 ± 21 (s.d.) pg/ 100 mg tissue (Braasch et al 1955, Mazurova 1963, Arosenius 1964, Dimitriadou et al 1966, Ermans et al 1968, Fisher & Oddie 1969, Nagataki et al 1972, Le Blanc et al 1973, Larsen 1975, Robertson et al 1976, Imamura et al 1979, Tang Fui & Maisey 1983.…”

Section: Normal Valuesmentioning

confidence: 95%

Low intrathyroidal iodine concentration in non-endemic human goitres: a consequence rather than a cause of autonomous goitre growth

Aeschimann

Buergi²,

Wagner³

et al. 1994

Journal of Endocrinology

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Iodine may have an inhibitory and, in some circumstances, a stimulatory effect on thyroid follicular cell growth. Exogenous iodine deficiency causes the growth of endemic goitres and it has been claimed that low intrathyroidal iodine stores stimulate growth. On the other hand, the role of iodine, if any, in regulating the growth of human nodular goitres exposed to an ample supply of iodine has not been studied systematically. Very few data on intrathyroidal iodine concentration in this type of goitre are available. In the present work we have investigated total iodine content in 24 samples from 11 clinically and histomorphologically well-defined fast and autonomously growing human nodular goitres from a non-endemic area. Iodine was fractionated into thyroglobulin-iodine and non-thyroglobulin-iodine. The regional distribution of intrathyroidal iodo-compounds was also assessed in three goitres. Total iodine concentration, as well as its sub-fractions, i.e. thyroglobulin-iodine and non-thyroglobulin-iodine, were significantly lower than in normal thyroids. Furthermore, there was large inter- and intraindividual heterogeneity of all iodo-compounds as well as of thyroglobulin. Total iodine concentration varied by a factor of almost 40 between different goitre samples and by a factor of 20 between samples taken from the same goitre. Total non-thyroglobulin-iodine, the only fraction comprising possible cell growth-regulating iodo-compounds, varied by a factor of> 60 between different goitres and by a factor of > 6 between different samples of the same goitre. The low iodine concentration in all our goitre samples did not differ from values reported in the literature for endemic iodine-deficient goitres. Since all goitres studied here were actively growing while exposed to an ample supply of iodine, iodine shortage cannot be a primary and causal factor for the growth of this type of sporadic goitre. Rather, the low concentration and the large inter- and intraindividual heterogeneity of all iodo-compounds appear to be secondary incidental events well explained by the recently developed concept of autonomous thyroid growth.

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Endokrinologische Aspekte der normocalcämischen Hypercalciurie

Zechner¹,

Penner²,

Weissei³

et al. 1977

Fortschritte Der Urologie Und Nephrologie

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Total Thyroidal Content of Iodine in Thyrotoxic Patients Measured by in Vivo Neutron Activation Analysis

Cited by 13 publications

References 12 publications

Influence of sex, age and thyroid function indices on dual-energy computed tomography-derived quantitative parameters of thyroid in patients with or without Hashimoto’s thyroiditis

Influence of sex, age and thyroid function indices on dual-energy computed tomography-derived quantitative parameters of thyroid in patients with or without Hashimoto’s thyroiditis

Low intrathyroidal iodine concentration in non-endemic human goitres: a consequence rather than a cause of autonomous goitre growth

Endokrinologische Aspekte der normocalcämischen Hypercalciurie

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