Measurement of the Interstitial Pressure in Subcutaneous Tissue in Dogs

Ladegaard‐Pedersen, H. J.

doi:10.1161/01.res.26.6.765

Cited by 25 publications

(7 citation statements)

References 9 publications

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“…The wick and capsule methods have been thought to measure the hydrostatic pressure of the interstitial space (Guyton, 1963;Scholander et al, 1968;Stremme, Maggert & Scholander, 1969;Ladegaard-Pedersen, 1970). However, it is probable that there is little, if any, free fluid in the interstitial space (McMaster & Parsons, 1939a, b;Guyton, Scheel & Murphree, 1966) and the possibility must be considered that the negative pressure is generated by the osmotic effect of the macromolecules of ground substance, trapped by mutual entanglement in a sieve of collagen fibrils acting as a semi-permeable membrane (Fessler, 1960;Laurent, 1970).…”

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confidence: 99%

Measurement of Interstitial ‘Fluid’ Pressure by Means of a Cotton Wick in Man and Animals: An Analysis of the Origin of the Pressure

et al. 1971

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1.A method for measuring interstitial 'fluid' pressure by using a wick consisting of long-stranded cotton wool at the interface of the tissue is described.2. A correct measurement of hydrostatic fluid pressure was obtained when the wick, connected to a suitable transducer, was applied to filter paper in which the channels contained fluid at a known subatmospheric pressure.3. A mean subatmospheric pressure of -1,6 cmHzO was recorded in the subcutaneous tissue of the normally hydrated frog; pressure fell with dehydration and rose with overhydration. 4. A mean subatmospheric pressure of -2·8 cmHzO was recorded in the subcutaneous tissues of the abdominal wall and scalp of the normally hydrated rat. Simultaneous measurements made at symmetrical sites showed a high degree of correlation. 5. A comparison of interstitial 'fluid' pressure in the subcutaneous tissues of the scalp (measured by a wick) and the abdominal wall (measured by a Guyton capsule), in both anaesthetized and conscious rats showed some degree of correlation. There was, however, a wide scatter of values.6. The interstitial 'fluid' pressure in the rat, measured by both wick and capsule, became more negative when the animals underwent frusemide diuresis; the capsule pressures fell more rapidly for a given degree of fluid loss. 7. The wick method was applied to the subcutaneous tissues of the arm in normal man; a mean atmospheric pressure of -3,4 cmHzO was recorded in five subjects. There were no untoward sequelae.8. The forces responsible for the measured pressure have been analysed. The recorded subatmospheric interstitial 'fluid' pressure in the rat rose towards atmospheric pressure and sometimes became positive when the wick was removed, soaked in

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confidence: 99%

Measurement of Interstitial ‘Fluid’ Pressure by Means of a Cotton Wick in Man and Animals: An Analysis of the Origin of the Pressure

et al. 1971

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“…Several attempts have been made to meassure tissue fluid pressure: Guyton et al (8) have measured an average pressure of -7 mm Hg in perforated plastic capsules chronically implanted in subcutaneous tissue of dogs. Negative pressure in interstitial fluid has also been obtained by other techniques (6,15,18,19), but considerably less negative than those measured by means of implanted capsules.…”

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confidence: 77%

Effect of Increased Venous Pressure on the Hydrostatic and Colloid Osmotic Pressure in Subcutaneous Interstitial Fluid in Rats: Edema-Preventing Mechanisms

Fadnes

1976

Scandinavian Journal of Clinical and Laboratory Investigation

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The purpose of the present experiments was to study the effect of a rise in local venous pressure pressure (Pv) on interstitial fluid hydrostatic (Pi) and colloid osmotic pressure (COPi) in rats. The Pv of the hind limb was increased by ligating the iliac veins and the inferior caval vein. Interstitial fluid for protein and COP determination was sampled from subcutaneous tissue of the hind limbs by a wick technique, and the Pi was measured by a modified Scholander technique. When the Pv was increased from 3 to 12 mm Hg, the COPi fell from 9 to 4 mm Hg. The Pi averaged -1 mm Hg under control conditions and was unchanged when the Pv was elevated to 12 mm Hg. No edema was detected. Higher rises in venous pressures resulted in further but less pronounced falls in interstitial fluid COP. Edema developed and the Pi increased to +1 to 2mm Hg. The results show that the fall in COPi is an important edema-preventing factor during increased venous pressure, whereas a rise in Pi only seems to oppose further increase of an already existing edema.

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“…the interstitial fluid hydrostatic and osmotic pressure) is comparatively small and often ignored (Zweifach & Intaglietta, 1968). Satisfactory measurements of the interstitial fluid pressure could not be obtained in these animals by the wick method (Scholander, Hargens & Miller, 1968;Ladegaard-Pedersen, 1970) which was the only technique which could be used in the circumstances (unpublished results).…”

Section: Discussionmentioning

confidence: 99%

The compensation of post‐traumatic oedema in the rabbit at different ages

Little¹

1974

The Journal of Physiology

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SUMMARY1. The compensation of fluid loss from the circulation after an LD50 period of bilateral hind-limb ischaemia in a thermoneutral environment has been studied in the rabbit from birth until young adulthood.2. The fluid loss from the circulation was calculated from the increase in the great vessel haematocrit value as the red cell volume and -ce11swere unchanged after limb ischaemia. This 'apparent' fluid loss was compared with the 'actual' fluid loss calculated from the increase in water content of the injured limbs.3. The 0-to 1-day-old rabbit was better able to restore fluid, and protein, to the circulation than the older animal and suffered a smaller percentage reduction in arterial blood pressure after an LD50 period of ischaemia.4. The better compensation of post-traumatic fluid loss during the first 48 hr of life may be explained by the high capillary filtration coefficient and the post-traumatic increase in plasma protein osmotic pressure found at that age.5. The more efficient restoration ofthe plasma volume by the 0-to 1-dayold rabbit may account for the increased ability to withstand posttraumatic fluid loss at that age.

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Measurement of the Interstitial Pressure in Subcutaneous Tissue in Dogs

Cited by 25 publications

References 9 publications

Measurement of Interstitial ‘Fluid’ Pressure by Means of a Cotton Wick in Man and Animals: An Analysis of the Origin of the Pressure

Measurement of Interstitial ‘Fluid’ Pressure by Means of a Cotton Wick in Man and Animals: An Analysis of the Origin of the Pressure

Effect of Increased Venous Pressure on the Hydrostatic and Colloid Osmotic Pressure in Subcutaneous Interstitial Fluid in Rats: Edema-Preventing Mechanisms

The compensation of post‐traumatic oedema in the rabbit at different ages

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