Measurement of the Subjective Effects of Methylphenidate in 11- to 15-Year-Old Children with Attention-Deficit/Hyperactivity Disorder

Martin, Catherine A.; Guenthner, Greg; Bingcang, Christopher; Rayens, Mary Kay; Kelly, Thomas C.

doi:10.1089/cap.2006.0020

Cited by 17 publications

(8 citation statements)

References 28 publications

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“…The Maddox Wing ocular task (see Walsh et al, 2008a), computerized Digit Symbol Substitution Task (DSST; McLeod et al, 1982) and Continuous Performance Task (CPT; Martin et al, 2007) also were completed.…”

Section: Methodsmentioning

confidence: 99%

Pharmacodynamic profile of tramadol in humans: influence of naltrexone pretreatment

et al. 2012

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Rationale-Tramadol is a prescription analgesic that activates mu opioid and monoamine receptor systems. Tramadol is thought to have limited abuse potential compared to mu opioid agonists, but laboratory data indicate that it shares some of their pharmacodynamic effects.Objectives-This study evaluated the effect of mu opioid receptor blockade with naltrexone on the pharmacodynamic action of tramadol in humans.Methods-This inpatient, double-blind, randomized, within-subject study examined the effects of oral placebo, tramadol (87.5, 175 and 350 mg) and hydromorphone (4 and 16 mg; positive control) after 1 hr pretreatment with oral naltrexone (0 and 50 mg). Ten recreational opioid users completed the study. Pharmacodynamic effects were measured before and for 7 hr after initial drug administration.Results-Lower doses of tramadol and hydromorphone were generally placebo-like. Hydromorphone (16 mg) produced prototypic mu opioid agonist-like effects that were blocked by naltrexone. Tramadol (350 mg) produced miosis and increased ratings of "Good Effects" and "Liking ," but also increased ratings of "Bad Effects." Naltrexone reversed tramadol-induced physiological effects and mydriasis emerged, but unlike results with hydromorphone, naltrexone only partially attenuated tramadol's positive subjective effects and actually enhanced several unpleasant subjective ratings.Conclusions-Naltrexone can be used to disentangle the mixed neuropharmacological actions of tramadol. High dose tramadol produces a mixed profile of effects. These data suggest that both mu and non-mu opioid actions play a role in tramadol's subjective profile of action.

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Section: Methodsmentioning

confidence: 99%

Pharmacodynamic profile of tramadol in humans: influence of naltrexone pretreatment

et al. 2012

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“…The peak plasma concentration of methylphenidate-IR is reached approximately 1–2 h after ingestion and the half-life of the drug in plasma is 2–4 h (Gualtieri et al, 1982). Earlier literature has revealed that peak effects from methylphenidate-IR on the performance of the CCPT are observed 1–2 h after it is taken in children and adolescents with ADHD (Martin et al, 2007). Therefore, the CCPT was administered 90 min after ingestion of the drug to maximize responses during the test session (Gualtieri et al, 1982).…”

Section: Methodsmentioning

confidence: 99%

Atomoxetine could improve intra-individual variability in drug-naïve adults with attention-deficit/hyperactivity disorder comparably with methylphenidate: A head-to-head randomized clinical trial

Lin

et al. 2016

J Psychopharmacol

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“…Addiction Research Center Inventory. Participants completed the short form of the ARCI, which is a 48-item questionnaire, adapted by Martin et al for use in developing children, 34 and consists of five subscales: amphetamine (A), a scale that provides an assessment of amphetamine-like effects, including ''I have a weird feeling'' or ''I feel more excited than dreamy''; benzedrine group (BG), a scale that provides a measure of benzedrinelike effects, intellectual efficiency, and energy, including ''My movements seem slower today'' and ''People might say I am a little too dull today''; lysergic acid diethylamide (LSD), a scale that provides a measure of dysphoria and somatic complaints, including ''I would be happy all the time if I felt as I do now'' and ''My movements seem faster than usual''; morphine-benzedrine group (MBG), a scale that provides a measure of euphoria, including ''Things around me seem more pleasing than usual'' and ''I feel so good that I know other people can tell it''; and pentobarbital-chlorpromazine-alcohol group (PCAG), a scale that provides a measure of sedation, including ''I feel drowsy'' and ''It seems harder to move around today''. 35 Subjects completed the ARCI once before and *30 and 60 minutes after beverage consumption.…”

Section: Questionnairesmentioning

confidence: 99%

Subjective Responses to Caffeine Are Influenced by Caffeine Dose, Sex, and Pubertal Stage

Temple

Ziegler

Martin

et al. 2015

Journal of Caffeine Research

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Our previous work has shown that there are sex differences in subjective responses to acute caffeine administration in adolescents. The purpose of this study was to determine if these sex differences are dependent on pubertal development. We examined subjective responses before and after administration of 0, 1, and 2 mg/kg of caffeine in pre- and postpubertal boys and girls ( = 112). In addition, we examined differences in subjective responses to acute caffeine in both the luteal and follicular phases of the menstrual cycle in postpubertal girls. Caffeine at both doses resulted in greater changes in responses on the Addiction Research Center Inventory and the Brief Assessment of Mood States compared with placebo. Girls reported greater increases from baseline to peak in feeling different and liking the feeling than boys after 2 mg/kg of caffeine regardless of pubertal stage. Postpubertal girls also had a greater decrease from baseline in reports of feeling high and greater increases from baseline in reports of wanting more than postpubertal males. Finally, girls had greater changes (both increases and decreases) in responses on the Brief Mood Questionnaire when in the follicular phase compared with the luteal phase. This was also true for reports of feeling high and feeling different on the Drug Effects Questionnaire. None of these effects varied as a function of usual caffeine use, suggesting that differences are not the result of tolerance or sensitization. These results suggest that subjective responses to caffeine emerge before puberty, but sex differences may be strengthened after pubertal development.

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Measurement of the Subjective Effects of Methylphenidate in 11- to 15-Year-Old Children with Attention-Deficit/Hyperactivity Disorder

Cited by 17 publications

References 28 publications

Pharmacodynamic profile of tramadol in humans: influence of naltrexone pretreatment

Pharmacodynamic profile of tramadol in humans: influence of naltrexone pretreatment

Atomoxetine could improve intra-individual variability in drug-naïve adults with attention-deficit/hyperactivity disorder comparably with methylphenidate: A head-to-head randomized clinical trial

Subjective Responses to Caffeine Are Influenced by Caffeine Dose, Sex, and Pubertal Stage

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