Measurement of transcutaneous oxygen pressure in normal and ischaemic skin

Abstract

The transcutaneous oxygen pressure (tcPo2) was measured by a polarographic technique in the legs of 161 volunteers and compared with the levels found in 62 patients with ischaemic skin due to peripheral vascular disease. The results show that the tcPO2 was related to the degree of ischaemia and, in many cases, was a more accurate guide to the viability of the skin than clinical assessment. Measurement of the transcutaneous oxygen pressure in the leg at the site of amputation in 24 patients with peripheral vascular disease showed that a preoperative level greater than 40 millimetres of mercury at an electrode temperature of 44 degrees Celsius was necessary for the skin of the stump to heal. The technique is simple, non-invasive and reliable. The tcPo2 accurately reflects the physiological and pathological changes in the circulation of the skin. It has potential in many fields of surgery where careful assessment of the viability of the skin is necessary. An accurate method of assessing the viability of skin would be invaluable in many ischaemic conditions including peripheral vascular disease and limb trauma associated with cutaneous damage and vascular injury.

Elevated vacuum suspension preserves residual-limb skin health in people with lower-limb amputation: Randomized clinical trial

“…Notably, out-of-socket LDF and TCOM measurements have been reported in people with lower-limb amputation [29][30]. Our out-ofsocket TCOM values are consistent with those that have been reported in literature [30][31].…”

Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

“…5B, the blood glucose in mice treated with GRV(E + I)-loaded MNs quickly declined to nearly 200 mg/dL within 0.5 h and maintained a normoglycemic state (<200 mg/dL) for up to 4 h before gradually increasing. We attributed this fast response rate to the fast generation of the local hypoxic microenvironment that quickly activated the dissociation of GRVs under a bioreductive condition; the relatively low diffusion rate of oxygen in vivo compared with hydrogen ions may facilitate this process further (43)(44)(45). When the enzyme dose in the MNs was reduced from 1 to 0.5 mg/kg, the blood glucose levels decreased to around 350 mg/dL within 0.5 h, and steadily increased afterward.…”

Preamputation evaluation of limb perfusion with laser Doppler imaging and transcutaneous gases

“…Thus, a fixed time interval for routine measurement of TcPO 2 is not advisable. In a study of younger subjects (mean age 45 years), mean values ranging from 69 to 74 mmHg TcPO 2 were reported at leg sites 10 cm below the knee [30]. In this case, age may explain the higher values since it has been found to negatively correlate with TcPO 2 [31].…”