Measurement of uncertainty for blood alcohol concentration by headspace gas chromatography

Hwang, Rong-Jen; Beltran, Jada; Rogers, Craig Milo; Barlow, Jeremy; Razatos, Gerasimos

doi:10.1080/00085030.2017.1312069

Cited by 16 publications

(7 citation statements)

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“…Several methods have been used to measure different analytes in complex matrixes including chromatography, immune-chromatography, mass spectrometry, nuclear magnetic resonance, polymerase chain reaction, ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy (FTIR) and IR, surface-enhanced Raman spectroscopy (SERS) and Raman, circular dichroism spectroscopy, spectrofluorimetric, which all are still applicable [9][10][11][12][13][14][15][16][17][18][19][20], but they have their boundaries, and some of these techniques suffer from low sensitivity and selectivity on their own. Issues of portability, slow responses, and complicated operation could also be mentioned as some of their problems [21]; thus, there is a need for new analytical procedures to provide rapid, specific analysis, and simple result interpretation [22].…”

Section: Introductionmentioning

confidence: 99%

State of the Art in Alcohol Sensing with 2D Materials

2020

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Section: Introductionmentioning

confidence: 99%

State of the Art in Alcohol Sensing with 2D Materials

2020

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“…Among these, the enzymatic or gas chromatography mass spectrometry (GC-MS) are the most commonly used ( 11 - 14 ). The latest generation of headspace GC-MS techniques are superior with lower measurement uncertainty values ( 13 , 14 ).…”

Section: Discussionmentioning

confidence: 99%

Measurement uncertainty of blood ethanol concentration in drink-driving cases in an emergency laboratory

Üstündağ

Huysal

2017

Biochemia Medica

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IntroductionThe quality of blood ethanol concentration (BEC) determination is important because of its legal ramifications. Measurement uncertainty provides quantitative information about the quality and reliability of test results. In this study, we aim to calculate the measurement uncertainty for the ethanol test in our laboratory measured with a Synchron Systems Ethanol assay kit by employing an enzymatic rate method on the Beckman-Coulter Olympus AU400 auto analyzer (Beckman Coulter Inc, Melville, USA).Materials and methodsThe measurement uncertainty values were calculated in accordance to the Nordtest guidelines. All vehicle drivers involved in a traffic accident were retrospectively inspected for the BEC test conducted during July to December 2016 in our emergency laboratory.ResultsA 1034 vehicle drivers had their BEC tested. The results for 181 drivers were > 0.50 g/L and reported as positive. The serum ethanol concentration in those showing a positive result was 2.04 ± 1.01 g/L, over four times the legal limit. The median BEC in those showing a negative result was 0.03 (IQR: 0.03) g/L. The expanded uncertainty obtained was 19.74%. When measurement uncertainty values were added to the results of the 1034 drivers who were retrospectively screened, eight vehicle drivers had results with 95% confidence intervals that exceeded the legal limit 0.50 g/L.ConclusionsThe BEC test results for vehicle drivers with values close to legal limits should be reported as the obtained ethanol concentration with corresponding measurement uncertainty.

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“…The results in this study allowed forensic practitioners to both calculate and use reference variables in order to improve their calculations of uncertainty when using the Widmark equation for medicolegal purposes. The Toxicology Bureau of the New Mexico Department of Health conducted a study to estimate the uncertainty for blood alcohol concentration (BAC) by headspace-gas chromatography coupled with flame ionization detection (HS-GC-FID) [ 25 ] and another study to estimate the uncertainty for the preparation and testing of aqueous ethanol wet-bath simulator solutions which were used to perform calibration adjustments, calibration checks, proficiency testing, and inspection of evidential breath testing instruments [ 26 ].…”

Section: Surveillance In Toxicologymentioning

confidence: 99%