Measurement of urea, creatinine and urea to creatinine ratio using enzyme based chemical current conveyor (CCCII+)

Pookaiyaudom, P.; Seelanan, P.; Lidgey, F.J.; Hayatleh, K.; Toumazou, C.

doi:10.1016/j.snb.2010.11.015

Cited by 18 publications

(6 citation statements)

References 18 publications

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“…Використан-ня глюкозовмісних розчинів, постійний моні-торинг рівня глюкози в крові під час сеансів рекомендовані для зниження ризику розвитку гіпоглікемічних станів у хворих на цукровий діабет, які перебувають в умовах хронічного гемодіалізу [5,6]. Крім того, для контролю ефективності процедури гемодіалізу та для зменшення часу перебування пацієнта в не-зручних умовах, необхідний постійний контр-оль основних уремічних токсинів -сечовини та креатиніну [7][8][9]. В сучасній лабораторній діагностиці для кількісного аналізу зазначених метаболітів існують колориметричні методи аналізу.…”

Section: вступunclassified

MULTIBIOSENSOR SYSTEM BASED ON pH-SENSITIVE FIELD-EFFECT TRANSISTORS FOR SIMULTANEOUS DETERMINATION OF GLUCOSE, CREATININE AND UREA

Солдаткін¹,

Марченко²,

Кукла³

et al. 2018

SEMST

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Section: вступunclassified

MULTIBIOSENSOR SYSTEM BASED ON pH-SENSITIVE FIELD-EFFECT TRANSISTORS FOR SIMULTANEOUS DETERMINATION OF GLUCOSE, CREATININE AND UREA

Солдаткін¹,

Марченко²,

Кукла³

et al. 2018

SEMST

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“…Under this condition, the cross-linked reactions of creatinine and AuNPs would proceed effectively, resulting in the aggregation of AuNPs. However, creatinine was hydrolyzed and decomposed into N-methylhydantoin in strong acidic and strong basic media [22]. Compared with creatinine, the Nmethylhydantoin contained only two nitrogen-containing groups, which do not effectively generate the aggregation of AuNPs anymore.…”

Section: Optimization Of Detection Conditionsmentioning

confidence: 99%

Gold nanoparticles-based colorimetric and visual creatinine assay

Zhang

2015

Microchim Acta

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We demonstrate a selective and sensitive method for determination of creatinine using citrate-stabilized gold nanoparticles (AuNPs) as a colorimetric probe. It is based on a direct cross-linking reaction that occurs between creatinine and AuNPs that causes aggregation of AuNPs and results in a color change from wine red to blue. The absorption peak is shifted from 520 to 670 nm. Under the optimized conditions, the shift in the absorption peak is related the logarithm of the creatinine concentration in the 0.1 to 20 mM range, and the instrumental detection limit (LOD) is 80 μM. This LOD is about one order of magnitude better than that that of the Jaffé method (720 μM). The assay displays good selectivity over interfering substances including various inorganic ions, organic small compounds, proteins, and biothiols. It was successfully employed to the determination of creatinine in spiked human urine.

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“…[1][2][3][4][5][6][7][8][9][10][11][12] Ion-sensitive FETs (ISFETs) have been widely researched and used in biomedical applications, analytical chemistry and environmental monitoring. [13][14][15][16][17][18][19][20][21][22] The original ISFET is an open-gate MOSFET. Its gate oxide or an extra coated gate insulator such as Si 3 N 4 , Al 2 O 3 , or Ta 2 O 5 is used as a sensing membrane for H + ions.…”

Section: Introductionmentioning

confidence: 99%

CMOS pulse-width-modulation readout circuit with a wide modulation range for ion-sensitive FET-based sensors

Wang

et al. 2015

Jpn. J. Appl. Phys.

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A CMOS pulse-width-modulation readout circuit for sensors is presented. An input voltage, V sen , which comes from a sensor, is converted into a current I sen and then the I sen is used to generate a single pulse by a procedure of constant-time charging and then constant-current discharging. With two signals RESET and SW, a control signal generator produces two signals MS1 and MS2 to control the charging and discharging of the capacitor C p , and hence the sensitivity of the pulse width can be tuned by changing the period of the SW. The pulse width linearly depends on the V sen with a linearity of at least 99.996%. The integration of the readout circuit with an ion-sensitive field effect transistor (ISFET) exhibits a measured transfer characteristic of pulse width versus pH value with a sensitivity of %31.6 µs/pH and a linearity of 99.35% after a charging time of 500 µs at 25 °C.

show abstract

Measurement of urea, creatinine and urea to creatinine ratio using enzyme based chemical current conveyor (CCCII+)

Cited by 18 publications

References 18 publications

MULTIBIOSENSOR SYSTEM BASED ON pH-SENSITIVE FIELD-EFFECT TRANSISTORS FOR SIMULTANEOUS DETERMINATION OF GLUCOSE, CREATININE AND UREA

MULTIBIOSENSOR SYSTEM BASED ON pH-SENSITIVE FIELD-EFFECT TRANSISTORS FOR SIMULTANEOUS DETERMINATION OF GLUCOSE, CREATININE AND UREA

Gold nanoparticles-based colorimetric and visual creatinine assay

CMOS pulse-width-modulation readout circuit with a wide modulation range for ion-sensitive FET-based sensors

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