Measurement of Urinary S100B Protein Concentrations for the Early Identification of Brain Damage in Asphyxiated Full-term Infants

Gazzolo, Diego; Marinoni, Emanuela; Iorio, Raffaele; Bruschettini, Matteo; Kornacka, Maria; Lituania, Mario; Majewska, U.; Serra, Giovanni; Michetti, Fabrizio

doi:10.1001/archpedi.157.12.1163

Cited by 76 publications

(52 citation statements)

References 37 publications

(47 reference statements)

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“…Urinary protein S100B concentrations did not reach the levels previously recorded by Gazzolo [48] (highest of 0.09 µg/L compared with average, on first micturition, of 1.92 ± 0.33µg/L). In fact they were considerably lower than previous studies almost to the point of being undetectable.…”

Section: Local Pilot Studycontrasting

confidence: 69%

“…An alternative fluid needed to be established. Cerebrospinal fluid (CSF) was too high risk with the possibility of infection being potentially disastrous, so urine was used and found to be a sensitive tool for measuring this marker, identifying neonates with brain injury from peri-natal asphyxia and correlating the concentrations measured with neurological outcome up to one year following birth [48]. Thus urinary S100B…”

Section: (Appendix II For Modified Scandinavian Decision Pathway)mentioning

confidence: 99%

“…Italy, who has established strong correlations between elevated serum S100B concentrations and intra-ventricular haemorrhage [47] and subsequently a link between brain damage following peri-natal asphyxia and elevated urinary S100B concentrations [48]. Berger, in 2002, identified elevated S100B concentrations in the serum of closed head injury children with no elevation in the samples of control patients with extracranial fractures [49].…”

Section: Biochemical Markersmentioning

confidence: 99%

See 2 more Smart Citations

3: A Study of Outcomes Following Head Injury Among Children and Young Adults in Full-Time Education

Pickering

Townend

2008

Annals of Emergency Medicine

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Section: Local Pilot Studycontrasting

confidence: 69%

Section: (Appendix II For Modified Scandinavian Decision Pathway)mentioning

confidence: 99%

Section: Biochemical Markersmentioning

confidence: 99%

See 1 more Smart Citation

3: A Study of Outcomes Following Head Injury Among Children and Young Adults in Full-Time Education

Pickering

Townend

2008

Annals of Emergency Medicine

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“…S100B, 24 NSE, 25 IL-6, urinary uric acid, cardiac troponin-I, creatinine kinase, 26 Glial Fibrillary Acidic Protein (GFAP), 27 Cytochrome C, Caspase 9 have been studied as indicators of diagnostic and prognostic indicators in Hypoxic ischemic encephalopathy. In this study we evaluated the role of cytochrome c and caspase 9 in perinatal asphyxia.…”

Section: Mechanism Of Neuronal Injurymentioning

confidence: 99%

Comparison of cerebrospinal fluid Cytochrome-c and Caspase-9 as biomarkers for newborns with hypoxic ischemic encephalopathy with non-asphyxiated babies and followup of these biomarkers after day 7

Kalyani

Lakshmi

et al. 2015

Int J Res Med Sci

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“…Urinary S100B concentrations have been evaluated in one pediatric TBI study, and extensively in neonates with hypoxic-ischemic encephalopathy (Berger and Kochanek, 2006;Gazzolo et al, 2001Gazzolo et al, ,2003a.…”

Section: Biospecimen Collectionmentioning

confidence: 99%

Common Data Elements for Pediatric Traumatic Brain Injury: Recommendations from the Biospecimens and Biomarkers Workgroup

Berger

Beers²,

Papa

et al. 2012

Journal of Neurotrauma

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Biospecimens represent a critically important resource in pediatric brain injury research. Data from these specimens can be used to identify and classify injury, understand the molecular mechanisms underlying different types of brain injury, and ultimately identify therapeutic targets to tailor treatments for individual patient needs. To realize the full potential of biospecimens in pediatric traumatic brain injury (TBI), standardization and adoption of best practice guidelines are needed to ensure the quality and consistency of specimens. Multiple groups, including the National Cancer Institute (NCI), the International Society for Biological and Environmental Repositories (ISBER), and the Organisation for Economic Co-operation and Development (OECD), have previously published best practice guidelines for biospecimen resources. Recommendations have also been provided by the Biospecimens and Biomarkers Workgroup of the interagency TBI Common Data Elements (CDE) initiative. The recommendations from all of these sources, however, focus exclusively on adult biospecimen collection. There are no published pediatric-specific biospecimen collection guidelines. An additional workgroup was formed to specifically address this gap. The aim of the Pediatric TBI CDE Biospecimens and Biomarkers Workgroup was to provide recommendations for best practice guidelines to standardize the quality and accessibility of biospecimens for pediatric brain injury research in general, and for pediatric TBI research in particular. Consensus recommendations were developed by review of previously published adult-specific recommendations, including the recommendations of the original TBI Common Data Elements Biospecimens and Biomarkers Workgroup, and by participation in the interagency workshop ''Common Data Elements for TBI Research: Pediatric Considerations,'' held in Houston, Texas in March of 2010. These recommendations represent expert opinion on this subject. The authors of this article were members of the Biospecimens Workgroup. We hope that with adoption of these best practices, future investigators will be able to obtain biospecimens in a consistent way that meets the needs of pediatric patients, and helps to accelerate acquisition of pediatric-specific biomarker data.

show abstract

Measurement of Urinary S100B Protein Concentrations for the Early Identification of Brain Damage in Asphyxiated Full-term Infants

Abstract: Longitudinal S100B protein measurements in urine soon after birth are a useful tool to identify which asphyxiated infants are at risk of long-term neurologic sequelae.

Cited by 76 publications

References 37 publications

3: A Study of Outcomes Following Head Injury Among Children and Young Adults in Full-Time Education

3: A Study of Outcomes Following Head Injury Among Children and Young Adults in Full-Time Education

Comparison of cerebrospinal fluid Cytochrome-c and Caspase-9 as biomarkers for newborns with hypoxic ischemic encephalopathy with non-asphyxiated babies and followup of these biomarkers after day 7

Common Data Elements for Pediatric Traumatic Brain Injury: Recommendations from the Biospecimens and Biomarkers Workgroup

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