Measurement of Water Vapor Loss Through Human Nail In Vivo

Spruit, D.

doi:10.1111/1523-1747.ep12261225

Cited by 35 publications

(18 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have shown it possible to determine nail plate permeability coefficients using standard diffusion cell techniques (Walters et a1 1981). Results obtained for water agreed well with literature data on water transpiration through the nail plate (Burch & Winsor 1946;Spruit 1971;Baden et a1 1973). In pursuant studies the techniques have been extended to the permeation of some n-alkanols.…”

supporting

confidence: 86%

Physicochemical characterization of the human nail: permeation pattern for water and the homologous alcohols and differences with respect to the stratum corneum

Walters

Flynn

Marvel

1983

Journal of Pharmacy and Pharmacology

110

View full text Add to dashboard Cite

In order to develop a basic concept of the permeability of the human nail plate and thus create a better understanding of the toxic potentials and therapeutic possibilities of substances applied to the nail, avulsed cadaver nails have been placed in specially constructed diffusion chambers and their permeation by water and the n-alkanols through dodecanol, all in high aqueous dilution, has been investigated. The permeability coefficient of water is 16.5 X 10(-3) cm h-1 and that for methanol is 5.6 X 10(-3) cm h-1. Ethanol's permeability coefficient measured 5.8 X 10(-3) cm h-1. Permeability coefficients decreased systematically thereafter to a low value of 0.27 X 10(-3) cm h-1 at n-octanol. The middle chain length alkanols, n-pentanol through n-octanol, have similar permeability coefficients but n-decanol and n-dodecanol show higher rates of permeation. The data suggest that, as a membrane, the hydrated human nail plate behaves like a hydrogel of high ionic strength to the polar and semipolar alcohols. Declining permeability rates appear linked to decreased partitioning into the complex matrix of the plate as the compounds become hydrophobic. The results for n-decanol and n-dodecanol introduce the possibility that a parallel lipid pathway exists which favours the permeation of these exceedingly hydrophobic species.

show abstract

supporting

confidence: 86%

Physicochemical characterization of the human nail: permeation pattern for water and the homologous alcohols and differences with respect to the stratum corneum

Walters

Flynn

Marvel

1983

Journal of Pharmacy and Pharmacology

110

View full text Add to dashboard Cite

show abstract

“…The latter produces the nail plate, which overlies the nail bed and is framed and and transonychial water loss values ranging from 7 to 75 g/m 2 ؒ h -1 have been reported [17][18][19][20][21][22][23][24] . Despite the considerable body of literature on various properties of the nail plate, as described above, the pH of the nail plate (unlike skin pH) has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

An Assessment of the Human Nail Plate pH

Murdan

Milcovich

Goriparthi

2011

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Purpose of Study: To measure the pH of the surface of healthy nail plates. Procedures: The surface pH of human fingernails and big toenails was measured in vivo using a skin pH meter. The influence of washing, anatomical site (fingers/toes), side (left/right), digit (digits 1–5) and gender was determined. The pH of the nail interior was also measured. Results: The pH of the nail plate surface was around 5, with toenails having a significantly higher pH than fingernails. Immediately after hand washing, the nail surface pH increased significantly, from pH 5.1 ± 0.4 to 5.3 ± 0.5. However, this was not sustained with time, and the pH returned to prewashing levels within 20 min. Gender had an influence on unwashed, but not washed, nail plate pH. The pH of the nail plate interior was lower than that of its surface. Conclusions: It was possible to measure nail plate pH, and baseline values are provided.

show abstract

“…Few studies have documented human nail permeability (14)(15)(16)(17)(18)(19)(20)(21). Germann et al first described tape stripping on a nail to remove nail corneocytes (22).…”

mentioning

confidence: 99%

“…Transepidermal water loss (TEWL) is commonly used to assess SC integrity and is an indicator of skin water permeability. In analogy to TEWL, so-called transonychial water loss (TOWL) can also be measured (14)(15)(16)(17)(18)23).…”

mentioning

confidence: 99%