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SUMMARY.— The water vapour loss from irritated and non‐irritated skin sites was determined twice daily during a period of 19–42 days after the irritation. Diurnal variation of skin temperature gives anomalous values for water vapour loss but does not account for anomalous activation energies.

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The specific resistances (SR) of various substances (a.o. vaseline, wool-fat, emulsions, paraffins, vegetable oils, simple esters) to the passage of water were measured. The reliability of the experimental measurement was checked by calibration with n-hexa-decane as a reference substance. The effectiveness of the reduction of skin’s water vapour loss after application of some substances with a high SR was determined in relation to their measured SR. The influence of ambient circumstances and peculiar characteristics of the skin were investigated.