Measurements of oxidative stress status and antioxidant activity in chronic leukaemia patients

Al‐Gayyar, Mohammed M.H.; Eissa, Laila A.; Rabie, Ahmed; El-Gayar, Amal M.

doi:10.1211/jpp.59.3.0011

Cited by 57 publications

(36 citation statements)

References 45 publications

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“…These results are in accordance with the increase of TBARS levels in the serum of patients with chronic leukemia [24] and acute lymphoblastic leukemia [9, 25]. …”

Section: Discussionsupporting

confidence: 86%

Oxidative Stress in Tunisian Patients With Acute Lymphoblastic Leukemia and Its Involvement in Leukemic Relapse

Mahmoud¹,

Mdhaffar

Ghozzi³

et al. 2017

Journal of Pediatric Hematology/Oncology

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The aim of the present study was to evaluate in patients with acute lymphoblastic leukemia (ALL) the oxidative status and antioxidant defense and its involvement in the relapse of ALL. The plasmatic levels of malondialdehyde (MDA), advanced oxidation of protein products (AOPP) and reduced glutathione (GSH), and the plasmatic activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) were determined in 34 patients newly-diagnosed with ALL and compared with 92 healthy subjects. The plasmatic concentrations of MDA and AOPP were higher in ALL patients than in controls and increased during chemotherapy. A decrease in GPx activity and an increase in CAT and SOD activities and GSH plasma levels were observed in ALL patients, as compared to sex-matched controls. Moreover, SOD activity and GSH levels were significantly correlated with the relapse of ALL patients. These data suggest the involvement of oxidative stress in acute lymphoid leukaemias and leukaemic relapse.

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“…These results are in accordance with the increase of TBARS levels in the serum of patients with chronic leukemia [24] and acute lymphoblastic leukemia [9, 25]. …”

Section: Discussionsupporting

confidence: 86%

Oxidative Stress in Tunisian Patients With Acute Lymphoblastic Leukemia and Its Involvement in Leukemic Relapse

Mahmoud¹,

Mdhaffar

Ghozzi³

et al. 2017

Journal of Pediatric Hematology/Oncology

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“…This finding is consistent with several studies reporting that patients with hematological malignancies have a hyperoxidative state before any CR, suggesting an intrinsic process of the underlying disease or inherent to drug treatments prior to HSCT [11][12][13][14][15][16][17] . The CR with high-dose chemotherapy, to which the patients had been previously submitted, was able to exacerbate this hyperoxidative state.…”

Section: Discussionsupporting

confidence: 92%

Association of oxidative stress and DNA damage with grafting time in patients with multiple myeloma and lymphoma submitted to autologous hematopoietic stem cell transplantation

Duarte

Filho

Santos

et al. 2016

Rev. Assoc. Med. Bras.

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The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) and lymphoma (Hodgkin’s and non-Hodgkin’s). Biomarkers of oxidative stress and DNA damage index (DI) were performed at baseline (pre-CR) of the disease and during the conditioning regimen (CR), one day after the HSCT, ten days after HSCT and twenty days after HSCT, as well as in the control group consisting of 30 healthy individuals. The outcomes showed that both groups of patients had an hyperoxidative state with high DI when compared to baseline and to the control group and that the CR exacerbated this condition. However, after the follow-up period of the study, this picture was re-established to the baseline levels of each pathology. The study patients with MM showed a mean grafting time of 10.75 days (8 to 13 days), with 10.15 days (8 to 15 days) for the lymphoma patients. In patients with MM, there was a negative correlation between the grafting time and the basal levels of GPx (r = -0.54; p = 0.034), indicating that lower levels of this important enzyme are associated with a longer grafting time. For the DI, the correlation was a positive one (r = 0.529; p = 0.030). In the group with lymphoma, it was observed that the basal levels of NOx were positively correlated with grafting time (r = 0.4664, p = 0.032). The data indicate the potential of these biomarkers as predictors of toxicity and grafting time in patients with MM and Lymphomas submitted to autologous HSCT.

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“…Al-Gayyar et al (26) concluded that leukemia patients produce larger amounts of ROS than nonleukemia patients. Oltra et al (27) found that lymphocyte SOD and catalase activity is decreased in chronic lymphocytic leukemia, whereas GSH-Px activity is increased.…”

Section: Discussionmentioning

confidence: 99%

Involvement of Oxidative Stress in the Relapse of Acute Myeloid Leukemia

Zhou

Zhang

Wei

et al. 2010

Journal of Biological Chemistry

105

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The aims of the present study were to determine the level of oxidative stress and the salient factors leading to the relapse of acute myeloid leukemia (AML). Oxidative stress-related parameters and the expressions of specific genes were monitored in 102 cases of AML during a pretreatment period from a primary status to a relapse status. In addition, age-matched healthy subjects were classified as controls. The activities of adenosine deaminase and xanthine oxidase were higher in the relapse condition, whereas those of glutathione peroxidase, monoamine oxidase, and superoxide dismutase, and the total antioxidant capacity (T-AOC) were lower in the primary condition and in controls. Of particular note, levels of advanced oxidation protein products, malondialdehyde, and 8-hydroxydeoxyguanosine were also significantly higher in relapse patients. Furthermore, real-time PCR with SYBR Green revealed that the expression levels of human thioredoxin (TRX) and indoleamine 2,3-dioxygenase were increased in relapse patients. Pearson correlation analysis revealed that the T-AOC was positively correlated with GSH but negatively correlated with 8-OHdG, TRX, and indoleamine 2,3-dioxygenase. Linear regression showed that a low T-AOC and up-regulated TRX expression were the independent factors correlated with relapse. A strong association between oxidative stress and the incidence of disease relapse was observed, which has potential prognosis implications. These results indicate that oxidative stress is a crucial feature of AML and probably affects the development and relapse of AML.

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Measurements of oxidative stress status and antioxidant activity in chronic leukaemia patients

Cited by 57 publications

References 45 publications

Oxidative Stress in Tunisian Patients With Acute Lymphoblastic Leukemia and Its Involvement in Leukemic Relapse

Oxidative Stress in Tunisian Patients With Acute Lymphoblastic Leukemia and Its Involvement in Leukemic Relapse

Association of oxidative stress and DNA damage with grafting time in patients with multiple myeloma and lymphoma submitted to autologous hematopoietic stem cell transplantation

Involvement of Oxidative Stress in the Relapse of Acute Myeloid Leukemia

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