Globally, climate change is a challenge facing humans and their socio-economic activities, health, livelihood, and food security and is the most serious threat that adversely affects agricultural productivity; it will influence temperature and rainfall. The objective this review is to assess the effect of climate change and variability on agriculture. To achieve this objective different literature from different sources were collected, organized and summarized carefully. Even though, it is global problem, developing countries like Africa, are the most adversely affected by climate change due to low level adaptive capabilities of the countries. Climate change and agriculture are inextricably linked. Agriculture still depends fundamentally on the weather. In many parts of the world climate change has already caused a negative impact on agriculture, because of increasingly severe weather patterns. Similarly, year to year crop production substantially influenced by Climate variability even in high yield and high-technology agricultural areas. Its impacts of on agriculture have significant consequences on livelihoods, food production, and the overall economy of countries, particularly those with agriculture-based economies in the developing world by affecting crop production, livestock productivity, horticultural crops, aquaculture (fish production), apiculture. It is expected to continue to cause floods, worsen desertification and disrupt growing seasons.